| The Asymmetric Baylis− Hillman Reaction LJ Brzezinski, S Rafel, JW Leahy Journal of the American Chemical Society 119 (18), 4317-4318, 1997 | 236 | 1997 |
| Absolute Configuration of Phorboxazoles A and B from the Marine Sponge Phorbas sp. 1. Macrolide and Hemiketal Rings PA Searle, TF Molinski, LJ Brzezinski, JW Leahy Journal of the American Chemical Society 118 (39), 9422-9423, 1996 | 207 | 1996 |
| An unexpected rate acceleration practical improvements in the Baylis− hillman reaction S Rafel, JW Leahy The Journal of Organic Chemistry 62 (5), 1521-1522, 1997 | 166 | 1997 |
| Enantioselective total synthesis of the antitumor macrolide rhizoxin D JA Lafontaine, DP Provencal, C Gardelli, JW Leahy The Journal of Organic Chemistry 68 (11), 4215-4234, 2003 | 129 | 2003 |
| The first design and synthesis of a steroidal peptidomimetic. The potential value of peptidomimetics in elucidating the bioactive conformation of peptide ligands R Hirschmann, PA Sprengeler, T Kawasaki, JW Leahy, WC Shakespeare, ... Journal of the American Chemical Society 114 (24), 9699-9701, 1992 | 124 | 1992 |
| Total synthesis of rapamycin and demethoxyrapamycin AB Smith III, SM Condon, JA McCauley, JL Leazer Jr, JW Leahy, ... Journal of the American Chemical Society 117 (19), 5407-5408, 1995 | 123 | 1995 |
| c-MET modulators and method of use LC Bannen, DSM Chan, LE Dalrymple, V Jammalamadaka, RG Khoury, ... US Patent 7,977,345, 2011 | 95 | 2011 |
| A Unified Total Synthesis of the Immunomodulators (−)-Rapamycin and (−)-27-Demethoxyrapamycin: Construction of the C (21− 42) Perimeters AB Smith, SM Condon, JA McCauley, JL Leazer, JW Leahy, RE Maleczka Journal of the American Chemical Society 119 (5), 947-961, 1997 | 93 | 1997 |
| Protein kinase modulators and methods of use CA Buhr, TG Baik, S Ma, Z Tesfai, L Wang, S Epshteyn, AR Kennedy, ... US Patent 7,704,995, 2010 | 91 | 2010 |
| A Unified Total Synthesis of the Immunomodulators (−)-Rapamycin and (−)-27-Demethoxyrapamycin: Assembly of the Common C (1− 20) Perimeter and Final Elaboration AB Smith, SM Condon, JA McCauley, JL Leazer, JW Leahy, RE Maleczka Journal of the American Chemical Society 119 (5), 962-973, 1997 | 85 | 1997 |
| Total synthesis of the latrunculins AB Smith III, JW Leahy, I Noda, SW Remiszewski, NJ Liverton, R Zibuck Journal of the American Chemical Society 114 (8), 2995-3007, 1992 | 74 | 1992 |
| Discovery of a novel class of highly potent, selective, ATP-competitive, and orally bioavailable inhibitors of the mammalian target of rapamycin (mTOR) CS Takeuchi, BG Kim, CM Blazey, S Ma, HWB Johnson, NK Anand, ... Journal of Medicinal Chemistry 56 (6), 2218-2234, 2013 | 73 | 2013 |
| c-Met modulators and methods of use LC Bannen, DSM Chan, TP Forsyth, RG Khoury, JW Leahy, MB Mac, ... US Patent 7,579,473, 2009 | 73 | 2009 |
| Enantiospecific total synthesis of the potent antitumor macrolides cryptophycins 1 and 8 KM Gardinier, JW Leahy The Journal of Organic Chemistry 62 (21), 7098-7099, 1997 | 72 | 1997 |
| The asymmetric Baylis-Hillman reaction as a template in organic synthesis LJ Brzezinski, S Rafel, JW Leahy Tetrahedron 53 (48), 16423-16434, 1997 | 70 | 1997 |
| The versatile steroid nucleus: Design and synthesis of a peptidomimetic employing this novel scaffold. R Hirschmann, PA Sprengeler, T Kawasaki, JW Leahy, WC Shakespeare, ... Tetrahedron 49 (17), 3665-3676, 1993 | 68 | 1993 |
| 4-aryl-2-amino-pyrimidines or 4-aryl-2-aminoalkyl-pyrimidines as JAK-2 modulators and methods of use G Mann, N Aay, A Arcalas, SD Brown, WKV Chan, J Chen, H Du, ... US Patent 8,440,663, 2013 | 64 | 2013 |
| c-Met modulators and method of use LC Bannen, DS Chan, J Chen, TP Forsyth, TP Huynh, V Jammalamadaka, ... US Patent 8,476,298, 2013 | 62 | 2013 |
| c-Met modulators and methods of use LC Bannen, DSM Chan, J Chen, LE Dalrymple, TP Forsyth, TP Huynh, ... US Patent 9,174,947, 2015 | 61 | 2015 |
| Enantioselective Total Synthesis of Cannabinoids A Route for Analogue Development ZP Shultz, GA Lawrence, JM Jacobson, EJ Cruz, JW Leahy Organic letters 20 (2), 381-384, 2018 | 60 | 2018 |
