Disruption of histone methylation in developing sperm impairs offspring health transgenerationally K Siklenka, S Erkek, M Godmann, R Lambrot, S McGraw, C Lafleur, ... Science 350 (6261), aab2006, 2015 | 485 | 2015 |
Low paternal dietary folate alters the mouse sperm epigenome and is associated with negative pregnancy outcomes R Lambrot, C Xu, S Saint-Phar, G Chountalos, T Cohen, M Paquet, ... Nature communications 4 (1), 2889, 2013 | 468 | 2013 |
Phthalates Impair Germ Cell Development in the Human Fetal Testis in Vitro without Change in Testosterone Production R Lambrot, V Muczynski, C Lécureuil, G Angenard, H Coffigny, C Pairault, ... Environmental health perspectives 117 (1), 32-37, 2009 | 224 | 2009 |
The dynamic epigenetic program in male germ cells: Its role in spermatogenesis, testis cancer, and its response to the environment M Godmann, R Lambrot, S Kimmins Microscopy research and technique 72 (8), 603-619, 2009 | 138 | 2009 |
Use of organ culture to study the human fetal testis development: effect of retinoic acid R Lambrot, H Coffigny, C Pairault, AC Donnadieu, R Frydman, R Habert, ... The Journal of Clinical Endocrinology & Metabolism 91 (7), 2696-2703, 2006 | 124 | 2006 |
Histone H3 lysine 4 trimethylation in sperm is transmitted to the embryo and associated with diet-induced phenotypes in the offspring A Lismer, V Dumeaux, C Lafleur, R Lambrot, J Brind’Amour, MC Lorincz, ... Developmental cell 56 (5), 671-686. e6, 2021 | 100 | 2021 |
Concerns about the widespread use of rodent models for human risk assessments of endocrine disruptors R Habert, V Muczynski, T Grisin, D Moison, S Messiaen, R Frydman, ... Reproduction 147 (4), R119-R129, 2014 | 99 | 2014 |
Adverse effects of endocrine disruptors on the foetal testis development: focus on the phthalates. RĂŠ Habert, V Muczynski, A Lehraiki, R Lambrot, C LĂŠcureuil, ... Folia Histochemica et Cytobiologica 47 (5), 67-74, 2009 | 62 | 2009 |
High radiosensitivity of germ cells in human male fetus R Lambrot, H Coffigny, C Pairault, C Lécureuil, R Frydman, R Habert, ... The Journal of Clinical Endocrinology & Metabolism 92 (7), 2632-2639, 2007 | 55 | 2007 |
Sperm histone H3 lysine 4 tri-methylation serves as a metabolic sensor of paternal obesity and is associated with the inheritance of metabolic dysfunction AS Pepin, C Lafleur, R Lambrot, V Dumeaux, S Kimmins Molecular Metabolism 59, 101463, 2022 | 51 | 2022 |
The histone demethylase KDM1A is essential for the maintenance and differentiation of spermatogonial stem cells and progenitors R Lambrot, C Lafleur, S Kimmins The FASEB Journal 29 (11), 4402-4416, 2015 | 51 | 2015 |
Sex-specific differences in fetal germ cell apoptosis induced by ionizing radiation MJ Guerquin, C Duquenne, H Coffigny, V Rouiller-Fabre, R Lambrot, ... Human Reproduction 24 (3), 670-678, 2009 | 41 | 2009 |
Histone H3 tails containing dimethylated lysine and adjacent phosphorylated serine modifications adopt a specific conformation during mitosis and meiosis A Eberlin, C Grauffel, M Oulad-Abdelghani, F Robert, ME Torres-Padilla, ... Molecular and Cellular Biology 28 (5), 1739-1754, 2008 | 39 | 2008 |
A new method for toxicity assays on human and mouse fetal testis R Lambrot, G Livera, H Coffigny, C Pairault, R Frydman, R Habert, ... Biochimie 88 (11), 1831-1835, 2006 | 38 | 2006 |
Retinoid-sensitive steps in steroidogenesis in fetal and neonatal rat testes: in vitro and in vivo studies G Livera, C Pairault, R Lambrot, M Lelievre-Pegorier, JM Saez, R Habert, ... Biology of reproduction 70 (6), 1814-1821, 2004 | 37 | 2004 |
Whole-genome sequencing of H3K4me3 and DNA methylation in human sperm reveals regions of overlap linked to fertility and development R Lambrot, D Chan, X Shao, M Aarabi, T Kwan, G Bourque, S Moskovtsev, ... Cell Reports 36 (3), 2021 | 30 | 2021 |
Specialized distribution of the histone methyltransferase Ezh2 in the nuclear apical region of round spermatids and its interaction with the histone variant H1t2 R Lambrot, S Jones, S Saint‐Phar, S Kimmins Journal of andrology 33 (5), 1058-1066, 2012 | 28 | 2012 |
Histone methylation is a critical regulator of the abnormal expression of POU5F1 and RASSF1A in testis cancer cell lines R Lambrot, S Kimmins International journal of andrology 34 (2), 110-123, 2011 | 28 | 2011 |
β-Catenin stabilization in gonadotropes impairs FSH synthesis in male mice in vivo D Boerboom, V Kumar, A Boyer, Y Wang, R Lambrot, X Zhou, C Rico, ... Endocrinology 156 (1), 323-333, 2015 | 22 | 2015 |
Early-life exposure to environmental contaminants perturbs the sperm epigenome and induces negative pregnancy outcomes for three generations via the paternal lineage C Maurice, M Dalvai, R Lambrot, A Deschênes, MP Scott-Boyer, ... Epigenomes 5 (2), 10, 2021 | 20 | 2021 |