Therapeutic targeting of PP2A CM O’Connor, A Perl, D Leonard, J Sangodkar, G Narla The international journal of biochemistry & cell biology 96, 182-193, 2018 | 186 | 2018 |
Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth J Sangodkar, A Perl, R Tohme, J Kiselar, DB Kastrinsky, N Zaware, ... The Journal of clinical investigation 127 (6), 2081-2090, 2017 | 186 | 2017 |
Selective PP2A enhancement through biased heterotrimer stabilization D Leonard, W Huang, S Izadmehr, CM O’Connor, DD Wiredja, Z Wang, ... Cell 181 (3), 688-701. e16, 2020 | 137 | 2020 |
Small-molecule activators of protein phosphatase 2A for the treatment of castration-resistant prostate cancer K McClinch, RA Avelar, D Callejas, S Izadmehr, D Wiredja, A Perl, ... Cancer research 78 (8), 2065-2080, 2018 | 74 | 2018 |
Desmosomal cadherins in health and disease M Hegazy, AL Perl, SA Svoboda, KJ Green Annual Review of Pathology: Mechanisms of Disease 17 (1), 47-72, 2022 | 58 | 2022 |
RABL6A inhibits tumor-suppressive PP2A/AKT signaling to drive pancreatic neuroendocrine tumor growth S Umesalma, CA Kaemmer, JL Kohlmeyer, B Letney, AM Schab, JA Reilly, ... The Journal of clinical investigation 129 (4), 1641-1653, 2019 | 31 | 2019 |
Complete genome of Bacillus subtilis myophage CampHawk MP Ritz, AL Perl, JM Colquhoun, KR Chamakura, GF Kuty Everett Genome Announcements 1 (6), 10.1128/genomea. 00984-13, 2013 | 15 | 2013 |
Protein phosphatase 2A controls ongoing DNA replication by binding to and regulating cell division cycle 45 (CDC45) AL Perl, CM O’Connor, P Fa, FM Pozo, J Zhang, Y Zhang, G Narla Journal of Biological Chemistry 294 (45), 17043-17059, 2019 | 13 | 2019 |
Complete genome of Bacillus subtilis myophage grass SY Miller, JM Colquhoun, AL Perl, KR Chamakura, GF Kuty Everett Genome announcements 1 (6), 10.1128/genomea. 00857-13, 2013 | 11 | 2013 |
PP2A-B55alpha controls keratinocyte adhesion through dephosphorylation of the Desmoplakin C-terminus AL Perl, JL Koetsier, KJ Green Scientific reports 13 (1), 12720, 2023 | 4 | 2023 |
Transcriptional profiling of rare acantholytic disorders suggests common mechanisms of pathogenesis QR Roth-Carter, HE Burks, Z Ren, JL Koetsier, LC Tsoi, PW Harms, ... JCI insight 8 (16), 2023 | 2 | 2023 |
Desmosomes at a glance AL Perl, JL Pokorny, KJ Green Journal of Cell Science 137 (12), 2024 | | 2024 |
791 The phosphatase PP2A-B55α associates with desmosomes in a mechanosensitive manner to control epidermal adhesion and mechanics A Perl, J Koetsier, K Green Journal of Investigative Dermatology 143 (5), S136, 2023 | | 2023 |
401 PP2A-B55α dephosphorylates desmoplakin's C-terminus to regulate cell adhesion A Perl, J Koetsier, S Roselli, N Panicker, N Verrills, K Green Journal of Investigative Dermatology 142 (8), S68, 2022 | | 2022 |
Biased activation of PP2A through selective heterotrimer binding and stabilization D Leonard, W Huang, S Izadmehr, CM O'Connor, DD Wiredja, Z Wang, ... Cancer Research 80 (16_Supplement), 2981-2981, 2020 | | 2020 |
Leveraging Small Molecule Activators of Protein Phosphatase 2A (PP2A) to Elucidate PP2As Role in Regulating DNA Replication and Apoptosis AL Perl Case Western Reserve University, 2020 | | 2020 |
A RABL6A-PP2A-AKT Pathway Drives Pancreatic Neuroendocrine Tumor Growth SA Umesalma, C Kaemmer, J Kohlmeyer, B Letney, A Schab, R Sheehy, ... PANCREAS 48 (3), 453-454, 2019 | | 2019 |
Therapeutic activation of protein phosphatase 2A for the treatment of lung cancer J Sangodkar, R Tohme, J Kiselar, S Izadmehr, D Hoon, S Mazhar, A Perl, ... Cancer Research 76 (14_Supplement), 3865-3865, 2016 | | 2016 |