| Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis CH Wu, C Fallini, N Ticozzi, PJ Keagle, PC Sapp, K Piotrowska, P Lowe, ... Nature 488 (7412), 499-503, 2012 | 741 | 2012 |
| Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche FE Lock, PC McDonald, Y Lou, I Serrano, SC Chafe, C Ostlund, ... Oncogene 32 (44), 5210-5219, 2013 | 346 | 2013 |
| Regulation of pH by carbonic anhydrase 9 mediates survival of pancreatic cancer cells with activated KRAS in response to hypoxia PC McDonald, SC Chafe, WS Brown, S Saberi, M Swayampakula, ... Gastroenterology 157 (3), 823-837, 2019 | 175 | 2019 |
| Overcoming hypoxia-mediated tumor progression: combinatorial approaches targeting pH regulation, angiogenesis and immune dysfunction PC McDonald, SC Chafe, S Dedhar Frontiers in cell and developmental biology 4, 27, 2016 | 140 | 2016 |
| Carbonic anhydrase IX promotes myeloid-derived suppressor cell mobilization and establishment of a metastatic niche by stimulating G-CSF production SC Chafe, Y Lou, J Sceneay, M Vallejo, MJ Hamilton, PC McDonald, ... Cancer research 75 (6), 996-1008, 2015 | 136 | 2015 |
| Targeting hypoxia-induced carbonic anhydrase IX enhances immune-checkpoint blockade locally and systemically SC Chafe, PC McDonald, S Saberi, O Nemirovsky, G Venkateswaran, ... Cancer immunology research 7 (7), 1064-1078, 2019 | 127 | 2019 |
| The interactome of metabolic enzyme carbonic anhydrase IX reveals novel roles in tumor cell migration and invadopodia/MMP14-mediated invasion M Swayampakula, PC McDonald, M Vallejo, E Coyaud, SC Chafe, ... Oncogene 36 (45), 6244-6261, 2017 | 121 | 2017 |
| Genome-wide synthetic lethal screen unveils novel CAIX-NFS1/xCT axis as a targetable vulnerability in hypoxic solid tumors SC Chafe, FS Vizeacoumar, G Venkateswaran, O Nemirovsky, S Awrey, ... Science advances 7 (35), eabj0364, 2021 | 88 | 2021 |
| Overcoming adaptive resistance to KRAS and MEK inhibitors by co-targeting mTORC1/2 complexes in pancreatic cancer WS Brown, PC McDonald, O Nemirovsky, S Awrey, SC Chafe, ... Cell Reports Medicine 1 (8), 2020 | 70 | 2020 |
| Cancer therapeutic targeting of hypoxia induced carbonic anhydrase IX: from bench to bedside PC McDonald, SC Chafe, CT Supuran, S Dedhar Cancers 14 (14), 3297, 2022 | 68 | 2022 |
| Scyl1 facilitates nuclear tRNA export in mammalian cells by acting at the nuclear pore complex SC Chafe, D Mangroo Molecular biology of the cell 21 (14), 2483-2499, 2010 | 44 | 2010 |
| Integrin-linked kinase mediates therapeutic resistance of quiescent CML stem cells to tyrosine kinase inhibitors K Rothe, A Babaian, N Nakamichi, M Chen, SC Chafe, A Watanabe, ... Cell Stem Cell 27 (1), 110-124. e9, 2020 | 37 | 2020 |
| Cancer-selective metabolic vulnerabilities in MYC-amplified medulloblastoma WD Gwynne, Y Suk, S Custers, N Mikolajewicz, JK Chan, Z Zador, ... Cancer Cell 40 (12), 1488-1502. e7, 2022 | 33 | 2022 |
| Nutrient stress does not cause retrograde transport of cytoplasmic tRNA to the nucleus in evolutionarily diverse organisms SC Chafe, JB Pierce, MBK Eswara, AT McGuire, D Mangroo Molecular biology of the cell 22 (7), 1091-1103, 2011 | 26 | 2011 |
| Nuclear-cytoplasmic trafficking of NTF2, the nuclear import receptor for the RanGTPase, is subjected to regulation SC Chafe, JB Pierce, D Mangroo Public Library of Science 7 (8), e42501, 2012 | 15 | 2012 |
| Carving out its niche: a role for carbonic anhydrase IX in pre-metastatic niche development SC Chafe, S Dedhar Oncoimmunology 4 (12), e1048955, 2015 | 8 | 2015 |
| Syntaxin4-Munc18c interaction promotes breast tumor invasion and metastasis by regulating MT1-MMP trafficking MI Brasher, SC Chafe, PC McDonald, O Nemirovsky, G Gorshtein, ... Molecular Cancer Research 20 (3), 434-445, 2022 | 7 | 2022 |
| A Carbonic Anhydrase IX/SLC1A5 axis regulates glutamine metabolism dependent ferroptosis in hypoxic tumor cells G Venkateswaran, PC McDonald, SC Chafe, WS Brown, ZJ Gerbec, ... Molecular Cancer Therapeutics 22 (10), 1228-1242, 2023 | 6 | 2023 |
| Dual antigen T cell engagers targeting CA9 as an effective immunotherapeutic modality for targeting CA9 in solid tumors N Tatari, X Zhang, SC Chafe, D McKenna, KA Lawson, M Subapanditha, ... Frontiers in Immunology 13, 905768, 2022 | 6 | 2022 |
| Granulocyte colony stimulating factor expression in breast cancer and its association with carbonic anhydrase ix and immune checkpoints SC Chafe, N Riaz, S Burugu, D Gao, SCY Leung, AF Lee, CH Lee, ... Cancers 13 (5), 1022, 2021 | 6 | 2021 |
