GDF11 does not rescue aging-related pathological hypertrophy SC Smith, X Zhang, X Zhang, P Gross, T Starosta, S Mohsin, M Franti, ... Circulation research 117 (11), 926-932, 2015 | 204 | 2015 |
Generation and functional characterization of anti-human and anti-mouse IL-36R antagonist monoclonal antibodies R Ganesan, EL Raymond, D Mennerich, JR Woska Jr, G Caviness, ... MAbs 9 (7), 1143-1154, 2017 | 83 | 2017 |
GDF11 decreases pressure overload–induced hypertrophy, but can cause severe cachexia and premature death SC Harper, J Johnson, G Borghetti, H Zhao, T Wang, M Wallner, H Kubo, ... Circulation research 123 (11), 1220-1231, 2018 | 54 | 2018 |
Intrinsic physicochemical profile of marketed antibody-based biotherapeutics L Ahmed, P Gupta, KP Martin, JM Scheer, AE Nixon, S Kumar Proceedings of the National Academy of Sciences 118 (37), e2020577118, 2021 | 45 | 2021 |
Physicochemical rules for identifying monoclonal antibodies with drug-like specificity Y Zhang, L Wu, P Gupta, AA Desai, MD Smith, LA Rabia, SD Ludwig, ... Molecular pharmaceutics 17 (7), 2555-2569, 2020 | 43 | 2020 |
Crystal structure of human GDF11 AK Padyana, B Vaidialingam, DB Hayes, P Gupta, M Franti, NA Farrow Acta Crystallographica Section F: Structural Biology Communications 72 (3 …, 2016 | 36 | 2016 |
Discovery-stage identification of drug-like antibodies using emerging experimental and computational methods EK Makowski, L Wu, P Gupta, PM Tessier MAbs 13 (1), 1895540, 2021 | 35 | 2021 |
GDF11 treatment attenuates the recovery of skeletal muscle function after injury in older rats Y Zhou, N Sharma, D Dukes, MB Myzithras, P Gupta, A Khalil, J Kahn, ... The AAPS journal 19, 431-437, 2017 | 29 | 2017 |
An HLA-presented fragment of macrophage migration inhibitory factor is a therapeutic target for invasive breast cancer O Hawkins, B Verma, S Lightfoot, R Jain, A Rawat, S McNair, S Caseltine, ... The Journal of Immunology 186 (11), 6607-6616, 2011 | 29 | 2011 |
Differential binding activity of TGF-β family proteins to select TGF-β receptors AM Khalil, H Dotimas, J Kahn, JE Lamerdin, DB Hayes, P Gupta, M Franti Journal of Pharmacology and Experimental Therapeutics 358 (3), 423-430, 2016 | 26 | 2016 |
Crystal structure and receptor-interacting residues of MYDGF—a protein mediating ischemic tissue repair R Ebenhoch, A Akhdar, MR Reboll, M Korf-Klingebiel, P Gupta, ... Nature communications 10 (1), 5379, 2019 | 22 | 2019 |
Antibodies with weakly basic isoelectric points minimize trade-offs between formulation and physiological colloidal properties P Gupta, EK Makowski, S Kumar, Y Zhang, JM Scheer, PM Tessier Molecular pharmaceutics 19 (3), 775-787, 2022 | 19 | 2022 |
Development of an ultra-sensitive Simoa assay to enable GDF11 detection: a comparison across bioanalytical platforms M Myzithras, H Li, T Bigwarfe, E Waltz, P Gupta, S Low, DB Hayes, ... Bioanalysis 8 (6), 511-518, 2016 | 17 | 2016 |
Plasma concentrations of myeloid-derived growth factor in healthy individuals and patients with acute myocardial infarction as assessed by multiple reaction monitoring-mass … F Polten, MR Reboll, C Widera, T Kempf, K Bethmann, P Gupta, ... Analytical chemistry 91 (2), 1302-1308, 2018 | 16 | 2018 |
How can we discover developable antibody-based biotherapeutics? J Bauer, N Rajagopal, P Gupta, P Gupta, AE Nixon, S Kumar Frontiers in Molecular Biosciences 10, 1221626, 2023 | 9 | 2023 |
Sema3A antibody BI-X prevents cell permeability and cytoskeletal collapse in HRMECs and increases tip cell density in mouse oxygen-induced retinopathy N Zippel, CH Kenny, H Wu, M Garneau, R Kroe-Barrett, P Gupta, S Low, ... Translational Vision Science & Technology 11 (6), 17-17, 2022 | 8 | 2022 |
Human Dose and Pharmacokinetic Predictions for Biologics at Boehringer Ingelheim: A Retrospective Analysis R Grempler, J Ahlberg, E Germovsek, P Gupta, H Li, M Pilvankar, ... Advances in Therapy 41 (1), 364-378, 2024 | | 2024 |