Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes I Caruana, B Savoldo, V Hoyos, G Weber, H Liu, ES Kim, MM Ittmann, ... Nature medicine 21 (5), 524-529, 2015 | 720 | 2015 |
Armed oncolytic virus enhances immune functions of chimeric antigen receptor–modified T cells in solid tumors N Nishio, I Diaconu, H Liu, V Cerullo, I Caruana, V Hoyos, ... Cancer research 74 (18), 5195-5205, 2014 | 326 | 2014 |
GD2-CART01 for relapsed or refractory high-risk neuroblastoma F Del Bufalo, B De Angelis, I Caruana, G Del Baldo, MA De Ioris, A Serra, ... New England Journal of Medicine 388 (14), 1284-1295, 2023 | 196 | 2023 |
Choice of costimulatory domains and of cytokines determines CAR T-cell activity in neuroblastoma C Quintarelli, D Orlando, I Boffa, M Guercio, VA Polito, A Petretto, ... Oncoimmunology 7 (6), e1433518, 2018 | 136 | 2018 |
Generation of multi-leukemia antigen-specific T cells to enhance the graft-versus-leukemia effect after allogeneic stem cell transplant G Weber, U Gerdemann, I Caruana, B Savoldo, NF Hensel, KR Rabin, ... Leukemia 27 (7), 1538-1547, 2013 | 110 | 2013 |
T Lymphocytes Redirected against the Chondroitin Sulfate Proteoglycan-4 Control the Growth of Multiple Solid Tumors both In Vitro and In Vivo C Geldres, B Savoldo, V Hoyos, I Caruana, M Zhang, E Yvon, ... Clinical Cancer Research 20 (4), 962-971, 2014 | 99 | 2014 |
Bevacizumab-mediated tumor vasculature remodelling improves tumor infiltration and antitumor efficacy of GD2-CAR T cells in a human neuroblastoma preclinical model P Bocca, E Di Carlo, I Caruana, L Emionite, M Cilli, B De Angelis, ... Oncoimmunology 7 (1), e1378843, 2018 | 93 | 2018 |
Generation of tumor antigen-specific T cell lines from pediatric patients with acute lymphoblastic leukemia—implications for immunotherapy G Weber, I Caruana, RH Rouce, AJ Barrett, U Gerdemann, AM Leen, ... Clinical Cancer Research 19 (18), 5079-5091, 2013 | 90 | 2013 |
Adoptive immunotherapy using PRAME-specific T cells in medulloblastoma D Orlando, E Miele, B De Angelis, M Guercio, I Boffa, M Sinibaldi, A Po, ... Cancer research 78 (12), 3337-3349, 2018 | 84 | 2018 |
3D modeling of human cancer: A PEG-fibrin hydrogel system to study the role of tumor microenvironment and recapitulate the in vivo effect of oncolytic adenovirus F Del Bufalo, T Manzo, V Hoyos, S Yagyu, I Caruana, J Jacot, ... Biomaterials 84, 76-85, 2016 | 72 | 2016 |
Role of interferon-γ in immune-mediated graft failure after allogeneic hematopoietic stem cell transplantation P Merli, I Caruana, R De Vito, L Strocchio, G Weber, F Del Bufalo, ... haematologica 104 (11), 2314, 2019 | 61 | 2019 |
Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity CBN Lauson, S Tiberti, PA Corsetto, F Conte, P Tyagi, M Machwirth, ... Cell Metabolism 35 (4), 633-650. e9, 2023 | 59 | 2023 |
CD28. OX40 co-stimulatory combination is associated with long in vivo persistence and high activity of CAR. CD30 T cells M Guercio, D Orlando, S Di Cecca, M Sinibaldi, I Boffa, S Caruso, ... Haematologica 106 (4), 987, 2021 | 53 | 2021 |
Polymorphonuclear myeloid-derived suppressor cells impair the anti-tumor efficacy of GD2. CAR T-cells in patients with neuroblastoma N Tumino, G Weber, F Besi, F Del Bufalo, V Bertaina, P Paci, L Quatrini, ... Journal of hematology & oncology 14, 1-7, 2021 | 51 | 2021 |
From monoclonal antibodies to chimeric antigen receptors for the treatment of human malignancies I Caruana, I Diaconu, G Dotti Seminars in oncology 41 (5), 661-666, 2014 | 48 | 2014 |
AMBRA1 controls regulatory T-cell differentiation and homeostasis upstream of the FOXO3-FOXP3 axis J Becher, L Simula, E Volpe, C Procaccini, C La Rocca, P D’Acunzo, ... Developmental cell 47 (5), 592-607. e6, 2018 | 47 | 2018 |
Manipulating the metabolism to improve the efficacy of CAR T-cell immunotherapy M Pellegrino, F Del Bufalo, B De Angelis, C Quintarelli, I Caruana, ... Cells 10 (1), 14, 2020 | 45 | 2020 |
Dual IGF1R/IR inhibitors in combination with GD2-CAR T-cells display a potent anti-tumor activity in diffuse midline glioma H3K27M-mutant E de Billy, M Pellegrino, D Orlando, G Pericoli, R Ferretti, P Businaro, ... Neuro-oncology 24 (7), 1150-1163, 2022 | 43 | 2022 |
Interaction between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in Fusion Negative Rhabdomyosarcoma S Pomella, P Sreenivas, BE Gryder, L Wang, D Milewski, M Cassandri, ... Nature communications 12 (1), 192, 2021 | 38 | 2021 |
Universal ready-to-use immunotherapeutic approach for the treatment of cancer: expanded and activated polyclonal γδ memory T cells VA Polito, R Cristantielli, G Weber, F Del Bufalo, T Belardinilli, CM Arnone, ... Frontiers in immunology 10, 2717, 2019 | 37 | 2019 |