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Brian Sparling
Brian Sparling
Director, Medicinal Chemistry
在 alum.mit.edu 的电子邮件经过验证 - 首页
标题
引用次数
引用次数
年份
Enantioselective total synthesis of hyperforin
BA Sparling, DC Moebius, MD Shair
Journal of the American Chemical Society 135 (2), 644-647, 2013
1242013
Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that …
RF Graceffa, AA Boezio, J Able, S Altmann, LM Berry, C Boezio, JR Butler, ...
Journal of medicinal chemistry 60 (14), 5990-6017, 2017
672017
Decarboxylative anti-michael addition to olefins mediated by photoredox catalysis
GH Lovett, BA Sparling
Organic letters 18 (14), 3494-3497, 2016
512016
Total synthesis of (−)-nemorosone and (+)-secohyperforin
BA Sparling, JK Tucker, DC Moebius, MD Shair
Organic letters 17 (14), 3398-3401, 2015
452015
SmI2-Promoted Reformatsky-Type Coupling Reactions in Exceptionally Hindered Contexts
BA Sparling, RM Moslin, TF Jamison
Organic letters 10 (6), 1291-1294, 2008
422008
Sustainable Practices in Medicinal Chemistry Part 2: Green by Design: Miniperspective
I Aliagas, R Berger, K Goldberg, RT Nishimura, J Reilly, P Richardson, ...
Journal of medicinal chemistry 60 (14), 5955-5968, 2017
252017
Progress in the discovery of small molecule modulators of the Cys-loop superfamily receptors
BA Sparling, EF DiMauro
Bioorganic & Medicinal Chemistry Letters 27 (15), 3207-3218, 2017
242017
无主题
WO Patent 2014201206:A1, 0
22*
Strategic use of nickel (0)-catalyzed enyne–epoxide reductive coupling toward the synthesis of (−)-cyatha-3, 12-diene
BA Sparling, GL Simpson, TF Jamison
Tetrahedron 65 (16), 3270-3280, 2009
162009
High-throughput implementation of the nanobret target engagement intracellular kinase assay to reveal differential compound engagement by sik2/3 isoforms
HY Jin, Y Tudor, K Choi, Z Shao, BA Sparling, JG McGivern, A Symons
SLAS DISCOVERY: Advancing the Science of Drug Discovery 25 (2), 215-222, 2020
142020
Enantioselective Construction of Bridgehead Quaternary Carbon Containing Bicyclo [3.3. 1] nonanes by Palladium-Catalyzed Desymmetric Arylation
J Cai, Q Wei, XD Hu, Y Zhang, W Li, H Cong, W Liu, WB Liu
Synthesis 50 (08), 1661-1666, 2018
122018
Discovery and hit-to-lead evaluation of piperazine amides as selective, state-dependent Na V 1.7 inhibitors
BA Sparling, S Yi, J Able, H Bregman, EF DiMauro, RS Foti, H Gao, ...
MedChemComm 8 (4), 744-754, 2017
72017
Bicyclic sulfonamide compounds as sodium channel inhibitors
M Weiss, A Boezio, C Boezio, JR Butler, MY Chu-moyer, EF DiMauro, ...
US Patent 9,212,182, 2015
72015
Pharmacological assessment of sepiapterin reductase inhibition on tactile response in the rat
JT Meyer, BA Sparling, WJ McCarty, M Zhang, M Soto, S Schneider, ...
Journal of Pharmacology and Experimental Therapeutics 371 (2), 476-486, 2019
52019
Virtual screening to identify potent sepiapterin reductase inhibitors
H Gao, S Schneider, P Andrews, K Wang, X Huang, BA Sparling
Bioorganic & Medicinal Chemistry Letters 30 (2), 126793, 2020
42020
targeting DHX9 inhibition as a novel therapeutic modality in microsatellite instable colorectal cancer
J Castro, MH Daniels, C Lu, D Brennan, D Gotur, YT Lee, ...
Cancer Research 83 (7_Supplement), 1136-1136, 2023
32023
Total Synthesis of Hyperforin
BA Sparling
Harvard University, 2013
22013
Inhibition of KIF18A leads to mitotic arrest and robust anti-tumor activity in chromosomally instable tumors
MS Lynes, S Khan, T Hotz, BA Sparling, MM Zablocki, D Gotur, ...
Cancer Research 84 (6_Supplement), 3337-3337, 2024
12024
Abstract B073: Characterization of selective, allosteric inhibitors of human XRN1
GJ Lockbaum, EA Sickmier, BA Sparling, K Knockenhauer, N Holt, J Liu, ...
Molecular Cancer Therapeutics 22 (12_Supplement), B073-B073, 2023
12023
Pyridine sulfonamides
M Weiss, JR Butler, BC Milgram, G Rescourio, A Boezio, BA Sparling, ...
US Patent 10,668,067, 2020
12020
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