Enantioselective total synthesis of hyperforin BA Sparling, DC Moebius, MD Shair Journal of the American Chemical Society 135 (2), 644-647, 2013 | 124 | 2013 |
Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that … RF Graceffa, AA Boezio, J Able, S Altmann, LM Berry, C Boezio, JR Butler, ... Journal of medicinal chemistry 60 (14), 5990-6017, 2017 | 67 | 2017 |
Decarboxylative anti-michael addition to olefins mediated by photoredox catalysis GH Lovett, BA Sparling Organic letters 18 (14), 3494-3497, 2016 | 51 | 2016 |
Total synthesis of (−)-nemorosone and (+)-secohyperforin BA Sparling, JK Tucker, DC Moebius, MD Shair Organic letters 17 (14), 3398-3401, 2015 | 45 | 2015 |
SmI2-Promoted Reformatsky-Type Coupling Reactions in Exceptionally Hindered Contexts BA Sparling, RM Moslin, TF Jamison Organic letters 10 (6), 1291-1294, 2008 | 42 | 2008 |
Sustainable Practices in Medicinal Chemistry Part 2: Green by Design: Miniperspective I Aliagas, R Berger, K Goldberg, RT Nishimura, J Reilly, P Richardson, ... Journal of medicinal chemistry 60 (14), 5955-5968, 2017 | 25 | 2017 |
Progress in the discovery of small molecule modulators of the Cys-loop superfamily receptors BA Sparling, EF DiMauro Bioorganic & Medicinal Chemistry Letters 27 (15), 3207-3218, 2017 | 24 | 2017 |
无主题 WO Patent 2014201206:A1, 0 | 22* | |
Strategic use of nickel (0)-catalyzed enyne–epoxide reductive coupling toward the synthesis of (−)-cyatha-3, 12-diene BA Sparling, GL Simpson, TF Jamison Tetrahedron 65 (16), 3270-3280, 2009 | 16 | 2009 |
High-throughput implementation of the nanobret target engagement intracellular kinase assay to reveal differential compound engagement by sik2/3 isoforms HY Jin, Y Tudor, K Choi, Z Shao, BA Sparling, JG McGivern, A Symons SLAS DISCOVERY: Advancing the Science of Drug Discovery 25 (2), 215-222, 2020 | 14 | 2020 |
Enantioselective Construction of Bridgehead Quaternary Carbon Containing Bicyclo [3.3. 1] nonanes by Palladium-Catalyzed Desymmetric Arylation J Cai, Q Wei, XD Hu, Y Zhang, W Li, H Cong, W Liu, WB Liu Synthesis 50 (08), 1661-1666, 2018 | 12 | 2018 |
Discovery and hit-to-lead evaluation of piperazine amides as selective, state-dependent Na V 1.7 inhibitors BA Sparling, S Yi, J Able, H Bregman, EF DiMauro, RS Foti, H Gao, ... MedChemComm 8 (4), 744-754, 2017 | 7 | 2017 |
Bicyclic sulfonamide compounds as sodium channel inhibitors M Weiss, A Boezio, C Boezio, JR Butler, MY Chu-moyer, EF DiMauro, ... US Patent 9,212,182, 2015 | 7 | 2015 |
Pharmacological assessment of sepiapterin reductase inhibition on tactile response in the rat JT Meyer, BA Sparling, WJ McCarty, M Zhang, M Soto, S Schneider, ... Journal of Pharmacology and Experimental Therapeutics 371 (2), 476-486, 2019 | 5 | 2019 |
Virtual screening to identify potent sepiapterin reductase inhibitors H Gao, S Schneider, P Andrews, K Wang, X Huang, BA Sparling Bioorganic & Medicinal Chemistry Letters 30 (2), 126793, 2020 | 4 | 2020 |
targeting DHX9 inhibition as a novel therapeutic modality in microsatellite instable colorectal cancer J Castro, MH Daniels, C Lu, D Brennan, D Gotur, YT Lee, ... Cancer Research 83 (7_Supplement), 1136-1136, 2023 | 3 | 2023 |
Total Synthesis of Hyperforin BA Sparling Harvard University, 2013 | 2 | 2013 |
Inhibition of KIF18A leads to mitotic arrest and robust anti-tumor activity in chromosomally instable tumors MS Lynes, S Khan, T Hotz, BA Sparling, MM Zablocki, D Gotur, ... Cancer Research 84 (6_Supplement), 3337-3337, 2024 | 1 | 2024 |
Abstract B073: Characterization of selective, allosteric inhibitors of human XRN1 GJ Lockbaum, EA Sickmier, BA Sparling, K Knockenhauer, N Holt, J Liu, ... Molecular Cancer Therapeutics 22 (12_Supplement), B073-B073, 2023 | 1 | 2023 |
Pyridine sulfonamides M Weiss, JR Butler, BC Milgram, G Rescourio, A Boezio, BA Sparling, ... US Patent 10,668,067, 2020 | 1 | 2020 |