| Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer KL Bryant, CA Stalnecker, D Zeitouni, JE Klomp, S Peng, AP Tikunov, ... Nature medicine 25 (4), 628-640, 2019 | 579 | 2019 |
| SIRT5 stabilizes mitochondrial glutaminase and supports breast cancer tumorigenesis KS Greene, MJ Lukey, X Wang, B Blank, JE Druso, MJ Lin, CA Stalnecker, ... Proceedings of the National Academy of Sciences 116 (52), 26625-26632, 2019 | 98 | 2019 |
| Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells CA Stalnecker, SM Ulrich, Y Li, S Ramachandran, MK McBrayer, ... Proceedings of the National Academy of Sciences 112 (2), 394-399, 2015 | 97 | 2015 |
| Characterization of the interactions of potent allosteric inhibitors with glutaminase C, a key enzyme in cancer cell glutamine metabolism Q Huang, C Stalnecker, C Zhang, LA McDermott, P Iyer, J O’Neill, ... Journal of Biological Chemistry 293 (10), 3535-3545, 2018 | 95 | 2018 |
| RAS, wanted dead or alive: Advances in targeting RAS mutant cancers CA Stalnecker, CJ Der Science signaling 13 (624), eaay6013, 2020 | 77 | 2020 |
| Combination Therapies with CDK4/6 Inhibitors to Treat KRAS-Mutant Pancreatic Cancer CM Goodwin, AM Waters, JE Klomp, S Javaid, KL Bryant, CA Stalnecker, ... Cancer research 83 (1), 141-157, 2023 | 43 | 2023 |
| Mechanistic basis of glutaminase activation: a key enzyme that promotes glutamine metabolism in cancer cells Y Li, JW Erickson, CA Stalnecker, WP Katt, Q Huang, RA Cerione, ... Journal of Biological Chemistry 291 (40), 20900-20910, 2016 | 43 | 2016 |
| Concurrent inhibition of IGF1R and ERK increases pancreatic cancer sensitivity to autophagy inhibitors CA Stalnecker, KR Grover, AC Edwards, MF Coleman, R Yang, ... Cancer research 82 (4), 586-598, 2022 | 34 | 2022 |
| Conformational changes in the activation loop of mitochondrial glutaminase C: A direct fluorescence readout that distinguishes the binding of allosteric inhibitors from activators CA Stalnecker, JW Erickson, RA Cerione Journal of Biological Chemistry 292 (15), 6095-6107, 2017 | 24 | 2017 |
| CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment JE Klomp, YS Lee, CM Goodwin, B Papke, JA Klomp, AM Waters, ... Cell reports 37 (9), 2021 | 19 | 2021 |
| Targeting p130Cas-and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition AM Waters, TO Khatib, B Papke, CM Goodwin, GA Hobbs, JN Diehl, ... Cell reports 35 (13), 2021 | 19 | 2021 |
| TEAD Inhibition Overcomes YAP1/TAZ-Driven Primary and Acquired Resistance to KRASG12C Inhibitors AC Edwards, CA Stalnecker, A Jean Morales, KE Taylor, JE Klomp, ... Cancer Research 83 (24), 4112-4129, 2023 | 11 | 2023 |
| The activation loop and substrate-binding cleft of glutaminase C are allosterically coupled Y Li, S Ramachandran, TTT Nguyen, CA Stalnecker, RA Cerione, ... Journal of Biological Chemistry 295 (5), 1328-1337, 2020 | 8 | 2020 |
| Tumor-selective activity of RAS-GTP inhibition in pancreatic cancer UN Wasko, J Jiang, TC Dalton, A Curiel-Garcia, AC Edwards, Y Wang, ... Nature, 1-3, 2024 | 7 | 2024 |
| Fluorination at the 4 position alters the substrate behavior of l-glutamine and l-glutamate: Implications for positron emission tomography of neoplasias TM Jeitner, E Kristoferson, JA Azcona, JT Pinto, C Stalnecker, ... Journal of fluorine chemistry 192, 58-67, 2016 | 7 | 2016 |
| Susceptibility to autophagy inhibition is enhanced by dual IGF1R and MAPK/ERK inhibition in pancreatic cancer CA Stalnecker, MF Coleman, KL Bryant Autophagy 18 (7), 1737-1739, 2022 | 6 | 2022 |
| Author Correction: Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer KL Bryant, CA Stalnecker, D Zeitouni, JE Klomp, S Peng, AP Tikunov, ... Nature medicine 26 (6), 982-982, 2020 | 6 | 2020 |
| Detection of phenotype‐specific therapeutic vulnerabilities in breast cells using a CRISPR loss‐of‐function screen A Barkovskaya, CM Goodwin, K Seip, B Hilmarsdottir, S Pettersen, ... Molecular Oncology 15 (8), 2026-2045, 2021 | 5 | 2021 |
| Balancing redox stress: anchorage-independent growth requires reductive carboxylation CA Stalnecker, AA Cluntun, RA Cerione Translational cancer research 5 (Suppl 3), S433, 2016 | 5 | 2016 |
| Labeled glutaminase proteins, isolated glutaminase protein mutants, methods of use, and kit CA Stalnecker, JW Erickson, S Ramachandran, R Cerione US Patent 11,046,945, 2021 | 2 | 2021 |
Kirsten BryantAssistant Professor, University of North Carolina at Chapel Hill在 email.unc.edu 的电子邮件经过验证
