Oncometabolites suppress DNA repair by disrupting local chromatin signalling PL Sulkowski, S Oeck, J Dow, NG Economos, L Mirfakhraie, Y Liu, ... Nature 582 (7813), 586-591, 2020 | 241 | 2020 |
Krebs-cycle-deficient hereditary cancer syndromes are defined by defects in homologous-recombination DNA repair PL Sulkowski, RK Sundaram, S Oeck, CD Corso, Y Liu, S Noorbakhsh, ... Nature genetics 50 (8), 1086-1092, 2018 | 191 | 2018 |
Cediranib suppresses homology-directed DNA repair through down-regulation of BRCA1/2 and RAD51 AR Kaplan, SE Gueble, Y Liu, S Oeck, H Kim, Z Yun, PM Glazer Science translational medicine 11 (492), eaav4508, 2019 | 131 | 2019 |
New insights into protein kinase B/Akt signaling: role of localized Akt activation and compartment-specific target proteins for the cellular radiation response K Szymonowicz, S Oeck, NM Malewicz, V Jendrossek Cancers 10 (3), 78, 2018 | 117 | 2018 |
Covalent‐allosteric kinase inhibitors J Weisner, R Gontla, L van der Westhuizen, S Oeck, J Ketzer, P Janning, ... Angewandte Chemie International Edition 54 (35), 10313-10316, 2015 | 107 | 2015 |
Mitochondrial DNA stress signalling protects the nuclear genome Z Wu, S Oeck, AP West, KC Mangalhara, AG Sainz, LE Newman, ... Nature metabolism 1 (12), 1209-1218, 2019 | 106 | 2019 |
Hypoxia induces resistance to EGFR inhibitors in lung cancer cells via upregulation of FGFR1 and the MAPK pathway Y Lu, Y Liu, S Oeck, GJ Zhang, A Schramm, PM Glazer Cancer research 80 (21), 4655-4667, 2020 | 66 | 2020 |
Hypoxia promotes resistance to EGFR inhibition in NSCLC cells via the histone demethylases, LSD1 and PLU-1 Y Lu, Y Liu, S Oeck, PM Glazer Molecular Cancer Research 16 (10), 1458-1469, 2018 | 66 | 2018 |
The Focinator-a new open-source tool for high-throughput foci evaluation of DNA damage S Oeck, NM Malewicz, S Hurst, J Rudner, V Jendrossek Radiation oncology 10, 1-11, 2015 | 56 | 2015 |
Optimizing biodegradable nanoparticle size for tissue-specific delivery HK Mandl, E Quijano, HW Suh, E Sparago, S Oeck, M Grun, PM Glazer, ... Journal of Controlled Release 314, 92-101, 2019 | 49 | 2019 |
Proton irradiation increases the necessity for homologous recombination repair along with the indispensability of non-homologous end joining K Szymonowicz, A Krysztofiak, J van der Linden, A Kern, S Deycmar, ... Cells 9 (4), 889, 2020 | 47 | 2020 |
Activating Akt1 mutations alter DNA double strand break repair and radiosensitivity S Oeck, K Al-Refae, H Riffkin, G Wiel, R Handrick, D Klein, G Iliakis, ... Scientific reports 7 (1), 42700, 2017 | 44 | 2017 |
The Focinator v2-0–graphical interface, four channels, colocalization analysis and cell phase identification S Oeck, NM Malewicz, S Hurst, K Al-Refae, A Krysztofiak, V Jendrossek Radiation research 188 (1), 114-120, 2017 | 40 | 2017 |
Relating linear energy transfer to the formation and resolution of DNA repair foci after irradiation with equal doses of X-ray photons, plateau, or Bragg-peak protons S Oeck, K Szymonowicz, G Wiel, A Krysztofiak, J Lambert, B Koska, ... International Journal of Molecular Sciences 19 (12), 3779, 2018 | 34 | 2018 |
Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis M Dorsch, M Kowalczyk, M Planque, G Heilmann, S Urban, P Dujardin, ... Cell Reports 37 (8), 2021 | 32 | 2021 |
HER2 mediates clinical resistance to the KRASG12C inhibitor sotorasib, which is overcome by co-targeting SHP2 CSL Ho, AI Tüns, HU Schildhaus, M Wiesweg, BM Grüner, B Hegedus, ... European Journal of Cancer 159, 16-23, 2021 | 31 | 2021 |
PTEN regulates nonhomologous end joining by epigenetic induction of NHEJ1/XLF PL Sulkowski, SE Scanlon, S Oeck, PM Glazer Molecular Cancer Research 16 (8), 1241-1254, 2018 | 25 | 2018 |
Topical capsaicin in poly (lactic-co-glycolic) acid (PLGA) nanoparticles decreases acute itch and heat pain NM Malewicz, Z Rattray, S Oeck, S Jung, V Escamilla-Rivera, Z Chen, ... International Journal of Molecular Sciences 23 (9), 5275, 2022 | 20 | 2022 |
Restraining Akt1 phosphorylation attenuates the repair of radiation-induced DNA double-strand breaks and reduces the survival of irradiated cancer cells K Szymonowicz, S Oeck, A Krysztofiak, J Van der Linden, G Iliakis, ... International journal of molecular sciences 19 (8), 2233, 2018 | 20 | 2018 |
Epigenetic mechanisms of ATM activation after helicobacter pylori infection JC Santos, RZ Gambeloni, AT Roque, S Oeck, ML Ribeiro The American journal of pathology 188 (2), 329-335, 2018 | 13 | 2018 |