CRISPR–Cas9 strategy for activation of silent Streptomyces biosynthetic gene clusters MM Zhang, FT Wong, Y Wang, S Luo, YH Lim, E Heng, WL Yeo, RE Cobb, ... Nature chemical biology 13 (6), 607-609, 2017 | 318 | 2017 |
Auroramycin: A Potent Antibiotic from Streptomyces roseosporus by CRISPR‐Cas9 Activation YH Lim, FT Wong, WL Yeo, KC Ching, YW Lim, E Heng, S Chen, DJ Tsai, ... ChemBioChem 19 (16), 1716-1719, 2018 | 56 | 2018 |
Characterization of Cas proteins for CRISPR‐Cas editing in streptomycetes WL Yeo, E Heng, LL Tan, YW Lim, YH Lim, S Hoon, H Zhao, MM Zhang, ... Biotechnology and bioengineering 116 (9), 2330-2338, 2019 | 40 | 2019 |
CRISPR-Cas strategies for natural product discovery and engineering in actinomycetes E Heng, LL Tan, MM Zhang, FT Wong Process Biochemistry 102, 261-268, 2021 | 13 | 2021 |
Biosynthetic engineering of the antifungal, anti-MRSA auroramycin WL Yeo, E Heng, LL Tan, YW Lim, KC Ching, DJ Tsai, YW Jhang, ... Microbial cell factories 19, 1-11, 2020 | 13 | 2020 |
Identification and engineering of 32 membered antifungal macrolactone notonesomycins F Goh, MM Zhang, TR Lim, KN Low, CE Nge, E Heng, WL Yeo, FL Sirota, ... Microbial Cell Factories 19, 1-13, 2020 | 9 | 2020 |
Enhancing armeniaspirols production through multi-level engineering of a native Streptomyces producer E Heng, YW Lim, CY Leong, VWP Ng, SB Ng, YH Lim, FT Wong Microbial cell factories 22 (1), 84, 2023 | 8 | 2023 |
Exploring a general multi-pronged activation strategy for natural product discovery in Actinomycetes DWP Tay, LL Tan, E Heng, N Zulkarnain, KC Ching, M Wibowo, EJ Chin, ... Communications Biology 7 (1), 50, 2024 | 7 | 2024 |
CRISPR/Cas-Mediated Genome Editing of Streptomyces LL Tan, E Heng, N Zulkarnain, WC Hsiao, FT Wong, MM Zhang Recombineering: Methods and Protocols, 207-225, 2022 | 6 | 2022 |
Nat. Chem. Biol. MM Zhang, FT Wong, Y Wang, S Luo, YH Lim, E Heng, WL Yeo, RE Cobb, ... | 4 | 2016 |
Training old dogs to do new tricks: A general multi-pronged activation approach for natural product discovery in Actinomycetes D Tay, LL Tan, E Heng, N Zulkarnain, KC Ching, M Wibowo, E Chin, ... | 3 | 2022 |
Discovery, characterization, and engineering of an advantageous Streptomyces host for heterologous expression of natural product biosynthetic gene clusters E Klumbys, W Xu, L Koduru, E Heng, Y Wei, FT Wong, H Zhao, EL Ang Microbial Cell Factories 23 (1), 149, 2024 | 2 | 2024 |
Application of Cas12j for Streptomyces Editing LL Tan, E Heng, CY Leong, V Ng, LK Yang, DCS Seow, L Koduru, ... Biomolecules 14 (4), 486, 2024 | 2 | 2024 |
Cost-effective hybrid long-short read assembly delineates alternative GC-rich Streptomyces hosts for natural product discovery E Heng, LL Tan, DWP Tay, YH Lim, LK Yang, DCS Seow, CY Leong, ... Synthetic and Systems Biotechnology 8 (2), 253-261, 2023 | 2 | 2023 |
Tandem mass spectral metabolic profiling of 54 actinobacterial strains and their 459 mutants DWP Tay, LL Tan, E Heng, N Zulkarnain, EJ Chin, ZYQ Tan, CY Leong, ... Scientific Data 11 (1), 977, 2024 | 1 | 2024 |
A linked Genomics Sequencing and Mass Spectrometry multi-modal dataset and models for Streamlined Natural Products Discovery in Microbial Strain Libraries DWP Tay, W Koh, SJ Ang, ZM Wong, YW Lim, E Heng, NZX Yeo, ... bioRxiv, 2025.01. 20.633932, 2025 | | 2025 |
Hyperporous encapsulation of microbes for whole cell biocatalysis and biomanufacturing J Zhang, K Chang, J Tay, E Tiong, E Heng, T Seah, YW Lim, G Peh, ... bioRxiv, 2024.06. 18.599529, 2024 | | 2024 |
Application of Cas12j for Streptomyces editing and cluster activation LL Tan, E Heng, N Zulkarnain, CY Leong, V Ng, LK Yang, DC San Seow, ... bioRxiv, 2021.10. 28.465406, 2021 | | 2021 |
MOESM2 of Biosynthetic engineering of the antifungal, anti-MRSA auroramycin W Yeo, E Heng, L Tan, Y Lim, K Ching, DJ Tsai, Y Jhang, TL Lauderdale, ... (No Title), 2020 | | 2020 |
Biosynthetic engineering of the antifungal, anti-MRSA auroramycin M Zhang, KC Ching, FT Wong, WL Yeo, YW Jhang, KS Shia, YW Lim, ... Microbial Cell Factories 19, 2019 | | 2019 |