Genetically engineered avidins and streptavidins OH Laitinen, VP Hytönen, HR Nordlund, MS Kulomaa Cellular and Molecular Life Sciences CMLS 63, 2992-3017, 2006 | 416 | 2006 |
Coxsackievirus B1 is associated with induction of β-cell autoimmunity that portends type 1 diabetes OH Laitinen, H Honkanen, O Pakkanen, S Oikarinen, MM Hankaniemi, ... Diabetes 63 (2), 446-455, 2014 | 332 | 2014 |
Brave new (strept) avidins in biotechnology OH Laitinen, HR Nordlund, VP Hytönen, MS Kulomaa Trends in biotechnology 25 (6), 269-277, 2007 | 268 | 2007 |
Biodiversity intervention enhances immune regulation and health-associated commensal microbiota among daycare children MI Roslund, R Puhakka, M Grönroos, N Nurminen, S Oikarinen, ... Science advances 6 (42), eaba2578, 2020 | 257 | 2020 |
Modern tools for rapid diagnostics of antimicrobial resistance A Vasala, VP Hytönen, OH Laitinen Frontiers in cellular and infection microbiology 10, 308, 2020 | 244 | 2020 |
Baculovirus-mediated periadventitial gene transfer to rabbit carotid artery KJ Airenne, MO Hiltunen, MP Turunen, AM Turunen, OH Laitinen, ... Gene therapy 7 (17), 1499-1504, 2000 | 203 | 2000 |
Recombinant NeutraLite avidin: a non-glycosylated, acidic mutant of chicken avidin that exhibits high affinity for biotin and low non-specific binding properties AT Marttila, OH Laitinen, KJ Airenne, T Kulik, EA Bayer, M Wilchek, ... FEBS letters 467 (1), 31-36, 2000 | 147 | 2000 |
Urbanization reduces transfer of diverse environmental microbiota indoors A Parajuli, M Grönroos, N Siter, R Puhakka, HK Vari, MI Roslund, ... Frontiers in microbiology 9, 84, 2018 | 137 | 2018 |
Enhanced gene delivery by avidin-displaying baculovirus JK Räty, KJ Airenne, AT Marttila, V Marjomäki, VP Hytönen, P Lehtolainen, ... Molecular therapy 9 (2), 282-291, 2004 | 133 | 2004 |
Baculovirus capsid display: a novel tool for transduction imaging SP Kukkonen, KJ Airenne, V Marjomäki, OH Laitinen, P Lehtolainen, ... Molecular Therapy 8 (5), 853-862, 2003 | 131 | 2003 |
Coxsackievirus B1 infections are associated with the initiation of insulin-driven autoimmunity that progresses to type 1 diabetes AB Sioofy-Khojine, J Lehtonen, N Nurminen, OH Laitinen, S Oikarinen, ... Diabetologia 61, 1193-1202, 2018 | 109 | 2018 |
Efficient production of active chicken avidin using a bacterial signal peptide in Escherichia coli VP Hytönen, OH Laitinen, TT Airenne, H Kidron, NJ Meltola, EJ Porkka, ... Biochemical Journal 384 (2), 385-390, 2004 | 108 | 2004 |
Detection of enteroviruses in stools precedes islet autoimmunity by several months: possible evidence for slowly operating mechanisms in virus-induced autoimmunity H Honkanen, S Oikarinen, N Nurminen, OH Laitinen, H Huhtala, ... Diabetologia 60 (3), 424-431, 2017 | 103 | 2017 |
Rational design of an active avidin monomer OH Laitinen, HR Nordlund, VP Hytönen, STH Uotila, AT Marttila, ... Journal of Biological Chemistry 278 (6), 4010-4014, 2003 | 100 | 2003 |
Short‐term direct contact with soil and plant materials leads to an immediate increase in diversity of skin microbiota M Grönroos, A Parajuli, OH Laitinen, MI Roslund, HK Vari, H Hyöty, ... MicrobiologyOpen 8 (3), e00645, 2019 | 93 | 2019 |
Enteroviral proteases: structure, host interactions and pathogenicity OH Laitinen, E Svedin, S Kapell, A Nurminen, VP Hytönen, ... Reviews in medical virology 26 (4), 251-267, 2016 | 93 | 2016 |
Improved generation of recombinant baculovirus genomes in Escherichia coli KJ Airenne, E Peltomaa, VP HytoÈnen, OH Laitinen, S Ylä‐Herttuala Nucleic acids research 31 (17), e101-e101, 2003 | 84 | 2003 |
Mutation of a critical tryptophan to lysine in avidin or streptavidin may explain why sea urchin fibropellin adopts an avidin‐like domain OH Laitinen, KJ Airenne, AT Marttila, T Kulik, E Porkka, EA Bayer, ... FEBS letters 461 (1-2), 52-58, 1999 | 80 | 1999 |
Nature-derived microbiota exposure as a novel immunomodulatory approach N Nurminen, J Lin, M Grönroos, R Puhakka, L Kramna, HK Vari, H Viskari, ... Future microbiology 13 (07), 737-744, 2018 | 78 | 2018 |
A Coxsackievirus B vaccine protects against virus-induced diabetes in an experimental mouse model of type 1 diabetes VM Stone, MM Hankaniemi, E Svedin, A Sioofy-Khojine, S Oikarinen, ... Diabetologia 61, 476-481, 2018 | 78 | 2018 |