| A novel positive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization RS Hurst, M Hajós, M Raggenbass, TM Wall, NR Higdon, JA Lawson, ... Journal of Neuroscience 25 (17), 4396-4405, 2005 | 532 | 2005 |
| The discovery of indoxacarb: oxadiazines as a new class of pyrazoline‐type insecticides SF McCann, GD Annis, R Shapiro, DW Piotrowski, GP Lahm, JK Long, ... Pest Management Science: formerly Pesticide Science 57 (2), 153-164, 2001 | 271 | 2001 |
| Organocerium additions to SAMP-hydrazones: General synthesis of chiral amines SE Denmark, T Weber, DW Piotrowski Journal of the American Chemical Society 109 (7), 2224-2225, 1987 | 179 | 1987 |
| Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain NG Lintner, KF McClure, D Petersen, AT Londregan, DW Piotrowski, ... PLoS biology 15 (3), e2001882, 2017 | 132 | 2017 |
| Expanding reactivity in DNA-encoded library synthesis via reversible binding of DNA to an inert quaternary ammonium support DT Flood, S Asai, X Zhang, J Wang, L Yoon, ZC Adams, BC Dillingham, ... Journal of the American Chemical Society 141 (25), 9998-10006, 2019 | 129 | 2019 |
| Design, synthesis, structure–activity relationship, and in vivo activity of azabicyclic aryl amides as α7 nicotinic acetylcholine receptor agonists DP Walker, DG Wishka, DW Piotrowski, S Jia, SC Reitz, KM Yates, ... Bioorganic & medicinal chemistry 14 (24), 8219-8248, 2006 | 122 | 2006 |
| Discovery of PF-04620110, a potent, selective, and orally bioavailable inhibitor of DGAT-1 RL Dow, JC Li, MP Pence, EM Gibbs, JL LaPerle, J Litchfield, ... ACS medicinal chemistry letters 2 (5), 407-412, 2011 | 100 | 2011 |
| Discovery of N-[(3R, 5R)-1-azabicyclo [3.2. 1] oct-3-yl] furo [2, 3-c] pyridine-5-carboxamide as an agonist of the α7 nicotinic acetylcholine receptor: In vitro and in vivo … BA Acker, EJ Jacobsen, BN Rogers, DG Wishka, SC Reitz, DW Piotrowski, ... Bioorganic & Medicinal Chemistry Letters 18 (12), 3611-3615, 2008 | 97 | 2008 |
| A small-molecule oral agonist of the human glucagon-like peptide-1 receptor DA Griffith, DJ Edmonds, JP Fortin, AS Kalgutkar, JB Kuzmiski, PM Loria, ... Journal of medicinal chemistry 65 (12), 8208-8226, 2022 | 82 | 2022 |
| Therapeutic compounds B Hulin, DW Piotrowski US Patent 7,291,618, 2007 | 80 | 2007 |
| Oxazolium-derived azomethine ylides. External oxazole activation and internal dipole trapping in the synthesis of an aziridinomitosene E Vedejs, DW Piotrowski, FC Tucci The Journal of Organic Chemistry 65 (18), 5498-5505, 2000 | 74 | 2000 |
| Quinuclidine-substituted heteroaryl moieties for treatment of disease JK Myers, BN Rogers, VE Groppi Jr, DW Piotrowski, AL Bodnar, ... US Patent 6,492,385, 2002 | 67 | 2002 |
| Quinuclidine-substituted aryl compounds for treatment of disease JK Myers, VE Groppi Jr, DW Piotrowski US Patent 6,486,172, 2002 | 67 | 2002 |
| Enantiocontrolled Synthesis of (1S,2S)-6-Desmethyl-(methylaziridino)mitosene E Vedejs, A Klapars, BN Naidu, DW Piotrowski, FC Tucci Journal of the American Chemical Society 122 (22), 5401-5402, 2000 | 65 | 2000 |
| Azabicyclic-substituted fused-heteroaryl compounds for the treatment of disease DP Walker, DW Piotrowski, EJ Jacobsen, BA Acker, DG Wishka, SC Reitz US Patent 6,911,543, 2005 | 64 | 2005 |
| Merging C (sp 3)–H activation with DNA-encoding Z Fan, S Zhao, T Liu, PX Shen, ZN Cui, Z Zhuang, Q Shao, JS Chen, ... Chemical Science 11 (45), 12282-12288, 2020 | 63 | 2020 |
| Synthesis and SAR of 1, 2, 3, 4-tetrahydroisoquinolin-1-ones as novel G-protein-coupled receptor 40 (GPR40) antagonists PS Humphries, JW Benbow, PD Bonin, D Boyer, SD Doran, RK Frisbie, ... Bioorganic & Medicinal Chemistry Letters 19 (9), 2400-2403, 2009 | 60 | 2009 |
| Regio-and Enantioselective Synthesis of Azole Hemiaminal Esters by Lewis Base Catalyzed Dynamic Kinetic Resolution DW Piotrowski, AS Kamlet, AMR Dechert-Schmitt, J Yan, TA Brandt, ... Journal of the American Chemical Society 138 (14), 4818-4823, 2016 | 59 | 2016 |
| The use of plasma aldosterone and urinary sodium to potassium ratio as translatable quantitative biomarkers of mineralocorticoid receptor antagonism RJ Eudy, V Sahasrabudhe, K Sweeney, M Tugnait, A King-Ahmad, ... Journal of translational medicine 9, 1-11, 2011 | 57 | 2011 |
| Quinuclidine-substituted heteroaryl moieties for treatment of disease JK Myers, BN Rogers, VE Groppi Jr, DW Piotrowski, AL Bodnar, ... US Patent 6,500,840, 2002 | 56 | 2002 |
Bruce RogersPfizer, University of California, University of Minnesota, Pharmacia, Morphic Therapeutic在 morphictx.com 的电子邮件经过验证
