| Induced protein degradation of histone deacetylases 3 (HDAC3) by proteolysis targeting chimera (PROTAC) F Cao, S de Weerd, D Chen, MRH Zwinderman, PE van der Wouden, ... European journal of medicinal chemistry 208, 112800, 2020 | 69 | 2020 |
| Inhibition of histone deacetylase 1 (HDAC1) and HDAC2 enhances CRISPR/Cas9 genome editing B Liu, S Chen, AL Rose, D Chen, F Cao, M Zwinderman, D Kiemel, ... Nucleic acids research 48 (2), 517-532, 2020 | 59 | 2020 |
| Histone deacetylase inhibitors sensitize TRAIL-induced apoptosis in colon cancer cells B Zhang, B Liu, D Chen, R Setroikromo, HJ Haisma, WJ Quax Cancers 11 (5), 645, 2019 | 48 | 2019 |
| Epigenetic regulation in macrophage migration inhibitory factor (MIF)-mediated signaling in cancer and inflammation A Osipyan, D Chen, FJ Dekker Drug discovery today 26 (7), 1728-1734, 2021 | 37 | 2021 |
| Proteolysis targeting chimera (PROTAC) for macrophage migration inhibitory factor (MIF) has anti‐proliferative activity in lung cancer cells Z Xiao, S Song, D Chen, R van Merkerk, PE van Der Wouden, RH Cool, ... Angewandte Chemie International Edition 60 (32), 17514-17521, 2021 | 36 | 2021 |
| CX Chemokine Receptor 7 Contributes to Survival of KRAS-Mutant Non-Small Cell Lung Cancer upon Loss of Epidermal Growth Factor Receptor B Liu, S Song, R Setroikromo, S Chen, W Hu, D Chen, AJ van der Wekken, ... Cancers 11 (4), 455, 2019 | 33 | 2019 |
| A novel histone acetyltransferase inhibitor A485 improves sensitivity of non-small-cell lung carcinoma cells to TRAIL B Zhang, D Chen, B Liu, FJ Dekker, WJ Quax Biochemical pharmacology 175, 113914, 2020 | 28 | 2020 |
| Structure-activity relationships for binding of 4-substituted triazole-phenols to macrophage migration inhibitory factor (MIF) Z Xiao, M Fokkens, D Chen, T Kok, G Proietti, R Van Merkerk, ... European Journal of Medicinal Chemistry 186, 111849, 2020 | 27 | 2020 |
| 7-Hydroxycoumarins are affinity-based fluorescent probes for competitive binding studies of macrophage migration inhibitory factor Z Xiao, D Chen, S Song, R van der Vlag, PE van der Wouden, ... Journal of Medicinal Chemistry 63 (20), 11920-11933, 2020 | 26 | 2020 |
| Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione Derivative Inhibits d-Dopachrome Tautomerase Activity and Suppresses the Proliferation of Non-Small Cell Lung … Z Xiao, A Osipyan, S Song, D Chen, RA Schut, R van Merkerk, ... Journal of Medicinal Chemistry 65 (3), 2059-2077, 2022 | 22 | 2022 |
| CRISPR-mediated ablation of overexpressed EGFR in combination with sunitinib significantly suppresses renal cell carcinoma proliferation B Liu, OA Diaz Arguello, D Chen, S Chen, A Saber, HJ Haisma Plos one 15 (5), e0232985, 2020 | 21 | 2020 |
| Modulating CRISPR/Cas9 genome-editing activity by small molecules S Chen, D Chen, B Liu, HJ Haisma Drug Discovery Today 27 (4), 951-966, 2022 | 18 | 2022 |
| Transcriptional activation of cyclin D1 via HER2/HER3 contributes to EGFR-TKI resistance in lung cancer B Liu, D Chen, S Chen, A Saber, H Haisma Biochemical Pharmacology 178, 114095, 2020 | 18 | 2020 |
| A bispecific inhibitor of the EGFR/ADAM17 axis decreases cell proliferation and migration of EGFR-dependent cancer cells A Soto-Gamez, D Chen, AGE Nabuurs, WJ Quax, M Demaria, ... Cancers 12 (2), 411, 2020 | 15 | 2020 |
| Discovery of highly potent HDAC8 PROTACs with anti-tumor activity C Zhao, D Chen, F Suo, R Setroikromo, WJ Quax, FJ Dekker Bioorganic Chemistry 136, 106546, 2023 | 12 | 2023 |
| HDAC/MIF dual inhibitor inhibits NSCLC cell survival and proliferation by blocking the AKT pathway F Cao, Z Xiao, S Chen, C Zhao, D Chen, HJ Haisma, FJ Dekker Bioorganic Chemistry 117, 105396, 2021 | 12 | 2021 |
| 4‐Iodopyrimidine labeling reveals nuclear translocation and nuclease activity for both MIF and MIF2 Z Xiao, D Chen, F Mulder, S Song, PE van der Wouden, RH Cool, ... Chemistry–A European Journal 28 (1), e202103030, 2022 | 7 | 2022 |
| Allosteric inhibitors of macrophage migration inhibitory factor (MIF) Interfere with Apoptosis-Inducing factor (AIF) Co-Localization to prevent Parthanatos D Chen, A Osipyan, J Adriana, M Kader, M Gureev, CWJ Knol, ... Journal of Medicinal Chemistry 66 (13), 8767-8781, 2023 | 5 | 2023 |
| Identification of a Bromodomain‐like Region in 15‐Lipoxygenase‐1 Explains Its Nuclear Localization D Chen, Z Xiao, H Guo, D Gogishvili, R Setroikromo, PE van der Wouden, ... Angewandte Chemie International Edition 60 (40), 21875-21883, 2021 | 5 | 2021 |
| Improving TRAIL-induced apoptosis in cancers by interfering with histone modifications BJ Zhang, D Chen, FJ Dekker, WJ Quax Cancer Drug Resistance 3 (4), 791, 2020 | 5 | 2020 |
