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Lingyan Chen
Lingyan Chen
Novo Nordisk Research Centre Oxford
在 novonordisk.com 的电子邮件经过验证 - 首页
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Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus
J Bentham, DL Morris, DSC Graham, CL Pinder, P Tombleson, ...
Nature genetics 47 (12), 1457, 2015
8632015
Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus
DL Morris, Y Sheng, Y Zhang, YF Wang, Z Zhu, P Tombleson, L Chen, ...
Nature genetics 48 (8), 940, 2016
3052016
Genetic advances in systemic lupus erythematosus: an update
L Chen, DL Morris, TJ Vyse
Current opinion in rheumatology 29 (5), 423-433, 2017
1462017
Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals
P Surendran, EV Feofanova, N Lahrouchi, I Ntalla, S Karthikeyan, J Cook, ...
Nature genetics 52 (12), 1314-1332, 2020
1322020
Interferon inducible X-linked gene CXorf21 may contribute to sexual dimorphism in Systemic Lupus Erythematosus
CA Odhams, AL Roberts, SK Vester, CST Duarte, CT Beales, AJ Clarke, ...
Nature communications 10 (1), 2164, 2019
882019
Genome-wide assessment of genetic risk for systemic lupus erythematosus and disease severity
DLM Lingyan Chen, Yong-Fei Wang, Lu Liu, Adrianna Bielowka, Rahell Ahmed ...
Human Molecular Genetics 29 (10), 1745–1756, 2020
732020
Mapping eQTLs with RNA-seq reveals novel susceptibility genes, non-coding RNAs and alternative-splicing events in systemic lupus erythematosus
CA Odhams, A Cortini, L Chen, AL Roberts, A Vinuela, A Buil, KS Small, ...
Human molecular genetics 26 (5), 1003-1017, 2017
602017
Systematic Mendelian randomization using the human plasma proteome to discover potential therapeutic targets for stroke
L Chen, JE Peters, B Prins, E Persyn, M Traylor, P Surendran, ...
Nature communications 13 (1), 6143, 2022
432022
Determinants of Gefitinib toxicity in advanced non-small cell lung cancer (NSCLC): a pharmacogenomic study of metabolic enzymes and transporters
Y Ma, S Xin, M Huang, Y Yang, C Zhu, H Zhao, Y Zhang, L Chen, Y Zhao, ...
The pharmacogenomics journal 17 (4), 325, 2017
432017
Genetic markers in CYP2C19 and CYP2B6 for prediction of cyclophosphamide's 4‐hydroxylation, efficacy and side effects in Chinese patients with systemic lupus erythematosus
W Shu, S Guan, X Yang, L Liang, J Li, Z Chen, Y Zhang, L Chen, X Wang, ...
British journal of clinical pharmacology 81 (2), 327-340, 2016
352016
Associations of MDR1, TBXA2R, PLA2G7, and PEAR1 genetic polymorphisms with the platelet activity in Chinese ischemic stroke patients receiving aspirin therapy
L Peng, Y Zhao, Z Zhou, J Jin, M Zhao, X Chen, L Chen, Y Cai, J Li, ...
Acta Pharmacologica Sinica 37 (11), 1442, 2016
342016
Mild-to-moderate kidney dysfunction and cardiovascular disease: observational and Mendelian randomisation analyses
L Gaziano, L Sun, M Arnold, S Bell, K Cho, SK Kaptoge, RJ Song, ...
Circulation, 2022
242022
The dissociation of Gefitinib trough concentration and clinical outcome in NSCLC patients with EGFR sensitive mutations
S Xin, Y Zhao, X Wang, Y Huang, J Zhang, Y Guo, J Li, H Li, Y Ma, L Chen, ...
Scientific reports 5, 12675, 2015
232015
Germline-encoded TCR-MHC contacts promote TCR V gene bias in umbilical cord blood T cell repertoire
K Gao, L Chen, Y Zhang, Y Zhao, Z Wan, J Wu, L Lin, Y Kuang, J Lu, ...
Frontiers in immunology 10, 2064, 2019
182019
The POR rs1057868–rs2868177 GC-GT diplotype is associated with high tacrolimus concentrations in early post-renal transplant recipients
S Liu, R Chen, J Li, Y Zhang, X Wang, Q Fu, L Chen, X Liu, H Huang, ...
Acta Pharmacologica Sinica 37 (9), 1251, 2016
172016
Elucidating mechanisms of genetic cross-disease associations at the PROCR vascular disease locus
D Stacey, L Chen, PJ Stanczyk, JMM Howson, AM Mason, S Burgess, ...
Nature communications 13 (1), 1-15, 2022
82022
Mapping eQTLs With RNA-Seq Reveals Novel SLE Susceptibility Genes, Non-Coding RNAs, and Alternative-Splicing Events That Are Concealed Using Microarrays
CA Odhams, A Cortini, L Chen, AL Roberts, A Vinuela, A Buil, KS Small, ...
bioRxiv, 076026, 2016
12016
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