O-GlcNAc modification blocks the aggregation and toxicity of the protein α-synuclein associated with Parkinson's disease NP Marotta, YH Lin, YE Lewis, MR Ambroso, BW Zaro, MT Roth, ... Nature chemistry 7 (11), 913-920, 2015 | 287 | 2015 |
Semisynthetic, site-specific ubiquitin modification of α-synuclein reveals differential effects on aggregation F Meier, T Abeywardana, A Dhall, NP Marotta, J Varkey, R Langen, ... Journal of the American Chemical Society 134 (12), 5468-5471, 2012 | 123 | 2012 |
O-GlcNAc modification prevents peptide-dependent acceleration of α-synuclein aggregation. NP Marotta, CA Cherwien, T Abeywardana, MR Pratt Chembiochem: a European journal of chemical biology 13 (18), 2665-2670, 2012 | 74 | 2012 |
The new chemical reporter 6-alkynyl-6-deoxy-GlcNAc reveals O-GlcNAc modification of the apoptotic caspases that can block the cleavage/activation of caspase-8 KN Chuh, AR Batt, BW Zaro, N Darabedian, NP Marotta, CK Brennan, ... Journal of the American Chemical Society 139 (23), 7872-7885, 2017 | 62 | 2017 |
N-terminal protein modification using simple aminoacyl transferase substrates AM Wagner, MW Fegley, JB Warner, CLJ Grindley, NP Marotta, ... Journal of the American Chemical Society 133 (38), 15139-15147, 2011 | 47 | 2011 |
Alpha-synuclein from patient Lewy bodies exhibits distinct pathological activity that can be propagated in vitro NP Marotta, J Ara, N Uemura, MG Lougee, ES Meymand, B Zhang, ... Acta neuropathologica communications 9, 1-18, 2021 | 41 | 2021 |
O-GlcNAc modification inhibits the calpain-mediated cleavage of α-synuclein PM Levine, CA De Leon, A Galesic, A Balana, NP Marotta, YE Lewis, ... Bioorganic & medicinal chemistry 25 (18), 4977-4982, 2017 | 35 | 2017 |
Synthetic proteins and peptides for the direct interrogation of α-synuclein posttranslational modifications MR Pratt, T Abeywardana, NP Marotta Biomolecules 5 (3), 1210-1227, 2015 | 22 | 2015 |
α-Synuclein aggregates amplified from patient-derived Lewy bodies recapitulate Lewy body diseases in mice N Uemura, NP Marotta, J Ara, ES Meymand, B Zhang, H Kameda, ... Nature Communications 14 (1), 6892, 2023 | 11 | 2023 |
O-GlcNAc modification blocks the aggregation and toxicity of the protein alpha-synuclein associated with Parkinson’s disease. Nat. Chem. 7, 913–920 NP Marotta, YH Lin, YE Lewis, MR Ambroso, BW Zaro, MT Roth, ... | 6 | 2015 |
Modeling the cellular fate of alpha-synuclein aggregates: A pathway to pathology NP Marotta, VMY Lee Current opinion in neurobiology 72, 171-177, 2022 | 5 | 2022 |
Distinct biological activity of Lewy body α-Synuclein strain in mice N Uemura, N Marotta, J Ara, E Meymand, B Zhang, H Kameda, M Koike, ... Research Square, 2023 | 4 | 2023 |
MSUT2 regulates tau spreading via adenosinergic signaling mediated ASAP1 pathway in neurons H Xu, Q Qiu, P Hu, K Hoxha, E Jang, M O’Reilly, C Kim, Z He, N Marotta, ... Acta Neuropathologica 147 (1), 55, 2024 | 2 | 2024 |
O‑GlcNAc modification blocks the aggregation and toxicity of the protein α‑synuclein associated with Parkinson’s disease. Nat Chem. 2015; 7: 913–20 NP Marotta, YH Lin, YE Lewis, MR Ambroso, BW Zaro, MT Roth, ... | 2 | |
Uncovering the Protective Role of Protein Glycosylation in Parkinson's Disease Utilizing Protein Semi-synthesis NP Marotta University of Southern California, 2015 | 1 | 2015 |
Highly tunable bimane-based fluorescent probes: design, synthesis, and application as a selective amyloid binding dye Y Venkatesh, NP Marotta, VMY Lee, EJ Petersson Chemical Science 15 (16), 6053-6063, 2024 | | 2024 |
O-GlcNAc modification blocks the aggregation and toxicity of the protein α-synuclein NP Marotta, YH Lin, YE Lewis Nature, 2015 | | 2015 |
Differential effects of site-specific sumoylation on alpha-synuclein aggregation TJ Abeywardana, NP Marotta, MR Pratt ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 248, 2014 | | 2014 |
O-GlcNAc modification prevents peptide-dependent acceleration of a-synuclein aggregation NP Marotta, CA Cherwien, T Abeywardana, MR Pratt ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 245, 2013 | | 2013 |