Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication R Di Micco, M Fumagalli, A Cicalese, S Piccinin, P Gasparini, C Luise, ... Nature 444 (7119), 638-642, 2006 | 2157 | 2006 |
Cellular senescence in ageing: from mechanisms to therapeutic opportunities R Di Micco, V Krizhanovsky, D Baker, F d’Adda di Fagagna Nature reviews Molecular cell biology 22 (2), 75-95, 2021 | 1424 | 2021 |
Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer R Di Micco, G Sulli, M Dobreva, M Liontos, OA Botrugno, G Gargiulo, ... Nature cell biology 13 (3), 292-302, 2011 | 409 | 2011 |
miR-30b/30d regulation of GalNAc transferases enhances invasion and immunosuppression during metastasis A Gaziel-Sovran, MF Segura, R Di Micco, MK Collins, D Hanniford, ... Cancer cell 20 (1), 104-118, 2011 | 388 | 2011 |
Oncogene-induced reactive oxygen species fuel hyperproliferation and DNA damage response activation M Ogrunc, R Di Micco, M Liontos, L Bombardelli, M Mione, M Fumagalli, ... Cell Death & Differentiation 21 (6), 998-1012, 2014 | 343 | 2014 |
Crosstalk between chromatin state and DNA damage response in cellular senescence and cancer G Sulli, R Di Micco, FA di Fagagna Nature Reviews Cancer 12 (10), 709-720, 2012 | 326 | 2012 |
Precise gene editing preserves hematopoietic stem cell function following transient p53-mediated DNA damage response G Schiroli, A Conti, S Ferrari, L Della Volpe, A Jacob, L Albano, S Beretta, ... Cell stem cell 24 (4), 551-565. e8, 2019 | 286 | 2019 |
Oncogene‐induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions A Suram, J Kaplunov, PL Patel, H Ruan, A Cerutti, V Boccardi, ... The EMBO journal 31 (13), 2839-2851, 2012 | 258 | 2012 |
Control of embryonic stem cell identity by BRD4-dependent transcriptional elongation of super-enhancer-associated pluripotency genes R Di Micco, B Fontanals-Cirera, V Low, P Ntziachristos, SK Yuen, ... Cell reports 9 (1), 234-247, 2014 | 242 | 2014 |
An early‐senescence state in aged mesenchymal stromal cells contributes to hematopoietic stem and progenitor cell clonogenic impairment through the activation of a pro … D Gnani, S Crippa, L Della Volpe, V Rossella, A Conti, E Lettera, S Rivis, ... Aging cell 18 (3), e12933, 2019 | 155 | 2019 |
Harnessing BET inhibitor sensitivity reveals AMIGO2 as a melanoma survival gene B Fontanals-Cirera, D Hasson, C Vardabasso, R Di Micco, P Agrawal, ... Molecular cell 68 (4), 731-744. e9, 2017 | 129 | 2017 |
Cellular and transcriptional dynamics of human neutrophils at steady state and upon stress E Montaldo, E Lusito, V Bianchessi, N Caronni, S Scala, L Basso-Ricci, ... Nature immunology 23 (10), 1470-1483, 2022 | 102 | 2022 |
Breaking news: high-speed race ends in arrest–how oncogenes induce senescence R Di Micco, M Fumagalli, FA di Fagagna Trends in cell biology 17 (11), 529-536, 2007 | 96 | 2007 |
DNA damage response activation in mouse embryonic fibroblasts undergoing replicative senescence and following spontaneous immortalization R Di Micco, A Cicalese, M Fumagalli, M Dobreva, A Verrecchia, ... Cell cycle 7 (22), 3601-3606, 2008 | 86 | 2008 |
Choice of template delivery mitigates the genotoxic risk and adverse impact of editing in human hematopoietic stem cells S Ferrari, A Jacob, D Cesana, M Laugel, S Beretta, A Varesi, G Unali, ... Cell Stem Cell 29 (10), 1428-1444. e9, 2022 | 76 | 2022 |
DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières syndrome astrocytes AMS Giordano, M Luciani, F Gatto, M Abou Alezz, C Beghè, L Della Volpe, ... Journal of Experimental Medicine 219 (4), e20211121, 2022 | 62 | 2022 |
Epigenetic therapies for acute myeloid leukemia and their immune-related effects V Gambacorta, D Gnani, L Vago, R Di Micco Frontiers in Cell and Developmental Biology 7, 207, 2019 | 41 | 2019 |
Integrated multiomic profiling identifies the epigenetic regulator PRC2 as a therapeutic target to counteract leukemia immune escape and relapse V Gambacorta, S Beretta, M Ciccimarra, L Zito, K Giannetti, A Andrisani, ... Cancer Discovery 12 (6), 1449-1461, 2022 | 38 | 2022 |
Longitudinal single-cell profiling of chemotherapy response in acute myeloid leukemia MM Naldini, G Casirati, M Barcella, PMV Rancoita, A Cosentino, ... Nature Communications 14 (1), 1285, 2023 | 34 | 2023 |
Genetic engineering meets hematopoietic stem cell biology for next-generation gene therapy S Ferrari, E Valeri, A Conti, S Scala, A Aprile, R Di Micco, ... Cell Stem Cell 30 (5), 549-570, 2023 | 30 | 2023 |