| Discovery of small-molecule degraders of the CDK9-cyclin T1 complex for targeting transcriptional addiction in prostate cancer J Li, T Liu, Y Song, M Wang, L Liu, H Zhu, Q Li, J Lin, H Jiang, K Chen, ... Journal of Medicinal Chemistry 65 (16), 11034-11057, 2022 | 36 | 2022 |
| Discovery of a subtype-selective, covalent inhibitor against palmitoylation pocket of TEAD3 T Lu, Y Li, W Lu, T Spitters, X Fang, J Wang, S Cai, J Gao, Y Zhou, Z Duan, ... Acta Pharmaceutica Sinica B 11 (10), 3206-3219, 2021 | 36 | 2021 |
| Thymine DNA glycosylase recognizes the geometry alteration of minor grooves induced by 5-formylcytosine and 5-carboxylcytosine T Fu, L Liu, QL Yang, Y Wang, P Xu, L Zhang, S Liu, Q Dai, Q Ji, GL Xu, ... Chemical science 10 (31), 7407-7417, 2019 | 23 | 2019 |
| Design, synthesis, and biological evaluation of 4-benzoylamino-1H-pyrazole-3-carboxamide derivatives as potent CDK2 inhibitors T Lin, J Li, L Liu, Y Li, H Jiang, K Chen, P Xu, C Luo, B Zhou European Journal of Medicinal Chemistry 215, 113281, 2021 | 21 | 2021 |
| A potent PGK1 antagonist reveals PGK1 regulates the production of IL-1β and IL-6 L Liao, W Dang, T Lin, J Yu, T Liu, W Li, S Xiao, L Feng, J Huang, R Fu, ... Acta Pharmaceutica Sinica B 12 (11), 4180-4192, 2022 | 18 | 2022 |
| Computational and structure-based development of high potent cell-active covalent inhibitor targeting the Peptidyl-Prolyl isomerase NIMA-Interacting-1 (Pin1) L Liu, R Zhu, J Li, Y Pei, S Wang, P Xu, M Wang, Y Wen, H Zhang, D Du, ... Journal of Medicinal Chemistry 65 (3), 2174-2190, 2022 | 18 | 2022 |
| Discovery of LL-K8-22: A Selective, Durable, and Small-Molecule Degrader of the CDK8-Cyclin C Complex M Wang, R Lin, J Li, Y Suo, J Gao, L Liu, L Zhou, Y Ni, Z Yang, J Zheng, ... Journal of Medicinal Chemistry 66 (7), 4932-4951, 2023 | 14 | 2023 |
| Discovery and characterization of a novel glucose-6-phosphate dehydrogenase (G6PD) inhibitor via high-throughput screening Z Luo, D Du, Y Liu, T Lu, L Liu, H Jiang, K Chen, C Shan, C Luo Bioorganic & Medicinal Chemistry Letters 40, 127905, 2021 | 11 | 2021 |
| Modular biomimetic strategy enabled discovery of simplified pseudo-natural macrocyclic P-glycoprotein inhibitors capable of overcoming multidrug resistance B Liu, X Yu, L Liu, L Wang, J Wang, Q Huang, Z Xu, C Luo, L Lou, ... Journal of Medicinal Chemistry 66 (4), 2550-2565, 2023 | 9 | 2023 |
| Selective bromodomain and extra-terminal bromodomain inhibitor inactivates macrophages and hepatic stellate cells to inhibit liver inflammation and fibrosis R Fu, SJ Zu, YJ Liu, JC Li, WZ Dang, LP Liao, LP Liu, PY Chen, ... Bioengineered 13 (4), 10914-10930, 2022 | 7 | 2022 |
| Discovery of a Covalent Inhibitor Selectively Targeting the Autophosphorylation Site of c-Src Kinase H Zhang, D Xu, H Huang, H Jiang, L Hu, L Liu, G Sun, J Gao, Y Li, C Xia, ... ACS Chemical Biology 19 (4), 999-1010, 2024 | 1 | 2024 |
| Dual-site molecular glues for enhancing protein-protein interactions of the CDK12-DDB1 complex Z Zhang, Y Li, J Yang, J Li, X Lin, T Liu, S Yang, J Lin, S Xue, J Yu, ... Nature Communications 15 (1), 6477, 2024 | | 2024 |
| Small Molecule Targeting PPM1A Activates Autophagy for Mycobacterium tuberculosis Host-Directed Therapy Z Yu, YC Liang, S Berton, L Liu, J Zou, L Chen, Z Xu, C Luo, J Sun, ... Journal of Medicinal Chemistry 67 (14), 11917-11936, 2024 | | 2024 |
