| Phosphorylation promotes neurotoxicity in a Caenorhabditis elegans model of TDP-43 proteinopathy NF Liachko, CR Guthrie, BC Kraemer Journal of Neuroscience 30 (48), 16208-16219, 2010 | 263 | 2010 |
| Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects J Mitra, EN Guerrero, PM Hegde, NF Liachko, H Wang, V Vasquez, J Gao, ... Proceedings of the National Academy of Sciences 116 (10), 4696-4705, 2019 | 251 | 2019 |
| TDP-43/FUS in motor neuron disease: Complexity and challenges EN Guerrero, H Wang, J Mitra, PM Hegde, SE Stowell, NF Liachko, ... Progress in neurobiology 145, 78-97, 2016 | 132 | 2016 |
| CDC7 inhibition blocks pathological TDP‐43 phosphorylation and neurodegeneration NF Liachko, PJ McMillan, CR Guthrie, TD Bird, JB Leverenz, BC Kraemer Annals of neurology 74 (1), 39-52, 2013 | 132 | 2013 |
| Protein kinase CK-1 inhibitors as new potential drugs for amyotrophic lateral sclerosis IG Salado, M Redondo, ML Bello, C Perez, NF Liachko, BC Kraemer, ... Journal of Medicinal Chemistry 57 (6), 2755-2772, 2014 | 129 | 2014 |
| The tau tubulin kinases TTBK1/2 promote accumulation of pathological TDP-43 NF Liachko, PJ McMillan, TJ Strovas, E Loomis, L Greenup, JR Murrell, ... PLoS genetics 10 (12), e1004803, 2014 | 114 | 2014 |
| Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration LM Taylor, PJ McMillan, NF Liachko, TJ Strovas, B Ghetti, TD Bird, ... Molecular neurodegeneration 13, 1-14, 2018 | 77 | 2018 |
| Resistance and resilience to Alzheimer’s disease pathology are associated with reduced cortical pTau and absence of limbic-predominant age-related TDP-43 encephalopathy in a … CS Latimer, BT Burke, NF Liachko, HN Currey, MD Kilgore, LE Gibbons, ... Acta neuropathologica communications 7, 1-24, 2019 | 76 | 2019 |
| Sertraline, paroxetine, and chlorpromazine are rapidly acting anthelmintic drugs capable of clinical repurposing JC Weeks, WM Roberts, C Leasure, BM Suzuki, KJ Robinson, H Currey, ... Scientific reports 8 (1), 975, 2018 | 74 | 2018 |
| Dopamine D2 receptor antagonism suppresses tau aggregation and neurotoxicity AV McCormick, JM Wheeler, CR Guthrie, NF Liachko, BC Kraemer Biological Psychiatry 73 (5), 464-471, 2013 | 68 | 2013 |
| An RNA aptamer that interferes with the DNA binding of the HSF transcription activator X Zhao, H Shi, A Sevilimedu, N Liachko, HCM Nelson, JT Lis Nucleic acids research 34 (13), 3755-3761, 2006 | 55 | 2006 |
| Constitutive XBP-1s-mediated activation of the endoplasmic reticulum unfolded protein response protects against pathological tau SM Waldherr, TJ Strovas, TA Vadset, NF Liachko, BC Kraemer Nature Communications 10 (1), 4443, 2019 | 53 | 2019 |
| The phosphatase calcineurin regulates pathological TDP-43 phosphorylation NF Liachko, AD Saxton, PJ McMillan, TJ Strovas, HN Currey, LM Taylor, ... Acta neuropathologica 132, 545-561, 2016 | 53 | 2016 |
| Regulation of TDP-43 phosphorylation in aging and disease RJ Eck, BC Kraemer, NF Liachko Geroscience 43 (4), 1605-1614, 2021 | 52 | 2021 |
| Targeting nuclear protein TDP-43 by cell division cycle kinase 7 inhibitors: A new therapeutic approach for amyotrophic lateral sclerosis E Rojas-Prats, L Martinez-Gonzalez, C Gonzalo-Consuegra, NF Liachko, ... European Journal of Medicinal Chemistry 210, 112968, 2021 | 40 | 2021 |
| Activity of the poly (A) binding protein MSUT2 determines susceptibility to pathological tau in the mammalian brain JM Wheeler, P McMillan, TJ Strovas, NF Liachko, A Amlie-Wolf, RL Kow, ... Science translational medicine 11 (523), eaao6545, 2019 | 26 | 2019 |
| Loss of RAD-23 protects against models of motor neuron disease by enhancing mutant protein clearance AM Jablonski, T Lamitina, NF Liachko, M Sabatella, J Lu, L Zhang, ... Journal of Neuroscience 35 (42), 14286-14306, 2015 | 26 | 2015 |
| TDP-43 promotes tau accumulation and selective neurotoxicity in bigenic Caenorhabditis elegans CS Latimer, JG Stair, JC Hincks, HN Currey, TD Bird, CD Keene, ... Disease Models & Mechanisms 15 (4), dmm049323, 2022 | 21 | 2022 |
| Tau tubulin kinases in proteinopathy LM Taylor, PJ McMillan, BC Kraemer, NF Liachko The FEBS journal 286 (13), 2434-2446, 2019 | 19 | 2019 |
| Genome wide analysis reveals heparan sulfate epimerase modulates TDP-43 proteinopathy NF Liachko, AD Saxton, PJ McMillan, TJ Strovas, CD Keene, TD Bird, ... PLoS genetics 15 (12), e1008526, 2019 | 15 | 2019 |
