| Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins DJ Schaer, PW Buehler, AI Alayash, JD Belcher, GM Vercellotti Blood, The Journal of the American Society of Hematology 121 (8), 1276-1284, 2013 | 762 | 2013 |
| CD163 is the macrophage scavenger receptor for native and chemically modified hemoglobins in the absence of haptoglobin DJ Schaer, CA Schaer, PW Buehler, RA Boykins, G Schoedon, AI Alayash, ... Blood 107 (1), 373-380, 2006 | 326 | 2006 |
| Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy JH Baek, F D’Agnillo, F Vallelian, CP Pereira, MC Williams, Y Jia, ... The Journal of clinical investigation 122 (4), 1444-1458, 2012 | 309 | 2012 |
| Haptoglobin, hemopexin, and related defense pathways—basic science, clinical perspectives, and drug development DJ Schaer, F Vinchi, G Ingoglia, E Tolosano, PW Buehler Frontiers in physiology 5, 415, 2014 | 284 | 2014 |
| Evidence of structural protein damage and membrane lipid remodeling in red blood cells from COVID-19 patients T Thomas, D Stefanoni, M Dzieciatkowska, A Issaian, T Nemkov, RC Hill, ... Journal of proteome research 19 (11), 4455-4469, 2020 | 269 | 2020 |
| Haptoglobin preserves the CD163 hemoglobin scavenger pathway by shielding hemoglobin from peroxidative modification PW Buehler, B Abraham, F Vallelian, C Linnemayr, CP Pereira, JF Cipollo, ... Blood, The Journal of the American Society of Hematology 113 (11), 2578-2586, 2009 | 221 | 2009 |
| Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs FS Boretti, PW Buehler, F D’Agnillo, K Kluge, T Glaus, OI Butt, Y Jia, ... The Journal of clinical investigation 119 (8), 2271-2280, 2009 | 220 | 2009 |
| Hemoglobin-based oxygen carriers: from mechanisms of toxicity and clearance to rational drug design PW Buehler, F D’Agnillo, DJ Schaer Trends in molecular medicine 16 (10), 447-457, 2010 | 169 | 2010 |
| Structural basis of peroxide-mediated changes in human hemoglobin: a novel oxidative pathway Y Jia, PW Buehler, RA Boykins, RM Venable, AI Alayash Journal of Biological Chemistry 282 (7), 4894-4907, 2007 | 162 | 2007 |
| Comparison of oral absorption and bioavailability of drugs between monkey and human WL Chiou, PW Buehler Pharmaceutical research 19, 868-874, 2002 | 151 | 2002 |
| Toxicological consequences of extracellular hemoglobin: biochemical and physiological perspectives PW Buehler, F D'Agnillo Antioxidants & redox signaling 12 (2), 275-291, 2010 | 137 | 2010 |
| Ascorbate removes key precursors to oxidative damage by cell-free haemoglobin in vitro and in vivo J Dunne, A Caron, P Menu, AI Alayash, PW Buehler, MT Wilson, ... Biochemical Journal 399 (3), 513-524, 2006 | 131 | 2006 |
| Toxicities of hemoglobin solutions: in search of in‐vitro and in‐vivo model systems PW Buehler, AI Alayash Transfusion 44 (10), 1516-1530, 2004 | 131 | 2004 |
| Hemoglobinuria-related acute kidney injury is driven by intrarenal oxidative reactions triggering a heme toxicity response JW Deuel, CA Schaer, FS Boretti, L Opitz, I García-Rubio, JH Baek, ... Cell death & disease 7 (1), e2064-e2064, 2016 | 129 | 2016 |
| Haptoglobin binding stabilizes hemoglobin ferryl iron and the globin radical on tyrosine β145 CE Cooper, DJ Schaer, PW Buehler, MT Wilson, BJ Reeder, G Silkstone, ... Antioxidants & redox signaling 18 (17), 2264-2273, 2013 | 119 | 2013 |
| Gating the radical hemoglobin to macrophages: the anti-inflammatory role of CD163, a scavenger receptor DJ Schaer, AI Alayash, PW Buehler Antioxidants & redox signaling 9 (7), 991-999, 2007 | 118 | 2007 |
| Coagulopathy and thrombosis as a result of severe COVID-19 infection: a microvascular focus UK Katneni, A Alexaki, RC Hunt, T Schiller, M DiCuccio, PW Buehler, ... Thrombosis and haemostasis 120 (12), 1668-1679, 2020 | 110 | 2020 |
| Extracellular vesicles from red blood cells and their evolving roles in health, coagulopathy and therapy K Thangaraju, SN Neerukonda, U Katneni, PW Buehler International journal of molecular sciences 22 (1), 153, 2020 | 107 | 2020 |
| Effects of endogenous ascorbate on oxidation, oxygenation, and toxicokinetics of cell-free modified hemoglobin after exchange transfusion in rat and guinea pig PW Buehler, F D'Agnillo, V Hoffman, AI Alayash Journal of Pharmacology and Experimental Therapeutics 323 (1), 49-60, 2007 | 102 | 2007 |
| Cell-free hemoglobin and its scavenger proteins: new disease models leading the way to targeted therapies DJ Schaer, PW Buehler Cold Spring Harbor perspectives in medicine 3 (6), a013433, 2013 | 100 | 2013 |
