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Jaafar N Haidar
Jaafar N Haidar
Senior Director of TCR Discovery and Engineering, Alloy Therapeutics
在 alloytx.com 的电子邮件经过验证
标题
引用次数
引用次数
年份
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
Management Group Liefer Laura A. 51 Wetterstrand Kris A. 51 Good Peter J. 51 ...
nature 447 (7146), 799-816, 2007
59922007
Structure‐based design of a T‐cell receptor leads to nearly 100‐fold improvement in binding affinity for pepMHC
JN Haidar, B Pierce, Y Yu, W Tong, M Li, Z Weng
Proteins: Structure, Function, and Bioinformatics 74 (4), 948-960, 2009
1032009
Somatostatin receptor-specific analogs: effects on cell proliferation and growth hormone secretion in human somatotroph tumors
DC Danila, JNS Haidar, X Zhang, L Katznelson, MD Culler, A Klibanski
The Journal of Clinical Endocrinology & Metabolism 86 (7), 2976-2981, 2001
892001
Molecular basis for necitumumab inhibition of EGFR variants associated with acquired cetuximab resistance
A Bagchi, JN Haidar, SW Eastman, M Vieth, M Topper, MD Iacolina, ...
Molecular cancer therapeutics 17 (2), 521-531, 2018
512018
A universal combinatorial design of antibody framework to graft distinct CDR sequences: A bioinformatics approach
JN Haidar, QA Yuan, L Zeng, M Snavely, X Luna, H Zhang, W Zhu, ...
Proteins: Structure, Function, and Bioinformatics 80 (3), 896-912, 2012
472012
Bispecific targeting of PD-1 and PD-L1 enhances T-cell activation and antitumor immunity
H Kotanides, Y Li, M Malabunga, C Carpenito, SW Eastman, Y Shen, ...
Cancer Immunology Research 8 (10), 1300-1310, 2020
462020
Discovery and preclinical characterization of the antagonist anti-PD-L1 monoclonal antibody LY3300054
Y Li, C Carpenito, G Wang, D Surguladze, A Forest, M Malabunga, ...
Journal for immunotherapy of cancer 6, 1-14, 2018
352018
Therapeutic high affinity T cell receptor targeting a KRASG12D cancer neoantigen
A Poole, V Karuppiah, A Hartt, JN Haidar, S Moureau, T Dobrzycki, ...
Nature communications 13 (1), 5333, 2022
342022
Overexpression of wild-type activin receptor alk4-1 restores activin antiproliferative effects in human pituitary tumor cells
DC Danila, X Zhang, Y Zhou, JNS Haidar, A Klibanski
The Journal of Clinical Endocrinology & Metabolism 87 (10), 4741-4746, 2002
302002
Comparison of predicted extinction coefficients of monoclonal antibodies with experimental values as measured by the Edelhoch method
H Maity, A Wei, E Chen, JN Haidar, A Srivastava, J Goldstein
International journal of biological macromolecules 77, 260-265, 2015
262015
Combinations of affinity-enhancing mutations in a T cell receptor reveal highly nonadditive effects within and between complementarity determining regions and chains
BG Pierce, JN Haidar, Y Yu, Z Weng
Biochemistry 49 (33), 7050-7059, 2010
242010
Backbone flexibility of CDR3 and immune recognition of antigens
JN Haidar, W Zhu, J Lypowy, BG Pierce, A Bari, K Persaud, X Luna, ...
Journal of molecular biology 426 (7), 1583-1599, 2014
192014
Characterization of 7A5: a human CD137 (4-1BB) receptor binding monoclonal antibody with differential agonist properties that promotes antitumor immunity
H Kotanides, RM Sattler, MB Lebron, C Carpenito, J Shen, J Li, ...
Molecular Cancer Therapeutics 19 (4), 988-998, 2020
152020
The molecular basis of blocking the TIM-3 checkpoint with the LY3321367 mAb in cancer immunotherapy
JN Haidar, S Antonysamy, S Mathew, L Wu, Y Zhang, MC Kearins, L Shen, ...
Cancer Research 79 (13_Supplement), 2753-2753, 2019
82019
882 Selective affinity-enhanced T cell receptor bispecific targeting of KRAS G12D neoantigen driven cancers
A Whale, A Poole, V Karuppiah, A Hartt, J Haidar, S Moureau, AB Lin, ...
Journal for ImmunoTherapy of Cancer 9 (Suppl 2), A924-A924, 2021
12021
Cd200 receptor antagonist binding molecules
KM Bell-mcguinn, SJ Demarest, KE Driscoll, RB Holmgaard, AM Russell, ...
US Patent App. 17/774,214, 2022
2022
Characterization of a human CD137 (4-1BB) receptor binding monoclonal antibody with differential agonist properties that promotes antitumor immunity
H Kotanides, RM Sattler, M Lebron, C Carpenito, J Shen, J Li, ...
JOURNAL FOR IMMUNOTHERAPY OF CANCER 7, 2019
2019
Preclinical characterization of the anti-PD-L1 monoclonal antibody LY3300054
C Carpenito, Y Li, GX Wang, MS Malabunga, JN Haidar, A Forest, ...
Cancer Research 78 (13_Supplement), 2730-2730, 2018
2018
A universal combinatorial design of antibody framework to graft distinct CDR sequences: A bioinformatics approach
JN Haidar, QA Yuan, L Zeng, M Snavely, X Luna, H Zhang, W Zhu, ...
Proteins: Structure, Function, and Bioinformatics 81 (9), 1677-1677, 2013
2013
A universal combinatorial design of antibody framework to graft distinct CDR sequences: A bioinformatics approach (vol 80, pg 896, 2012)
JN Haidar, QA Yuan, L Zeng, M Snavely, X Luna, H Zhang, W Zhu, ...
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS 81 (9), 1677-1677, 2013
2013
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