Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants JC Greene, AJ Whitworth, I Kuo, LA Andrews, MB Feany, LJ Pallanck Proceedings of the National Academy of Sciences 100 (7), 4078-4083, 2003 | 1434 | 2003 |
The PINK1/Parkin pathway regulates mitochondrial morphology AC Poole, RE Thomas, LA Andrews, HM McBride, AJ Whitworth, ... Proceedings of the National Academy of Sciences 105 (5), 1638-1643, 2008 | 1035 | 2008 |
Functional role of the β subunit of high conductance calcium-activated potassium channels OB McManus, LMH Helms, L Pallanck, B Ganetzky, R Swanson, ... Neuron 14 (3), 645-650, 1995 | 559 | 1995 |
The mitochondrial fusion-promoting factor mitofusin is a substrate of the PINK1/parkin pathway AC Poole, RE Thomas, S Yu, ES Vincow, L Pallanck PloS one 5 (4), e10054, 2010 | 504 | 2010 |
The PINK1–Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo ES Vincow, G Merrihew, RE Thomas, NJ Shulman, RP Beyer, ... Proceedings of the National Academy of Sciences 110 (16), 6400-6405, 2013 | 501 | 2013 |
Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease AJ Whitworth, DA Theodore, JC Greene, H Beneš, PD Wes, LJ Pallanck Proceedings of the National Academy of Sciences 102 (22), 8024-8029, 2005 | 483 | 2005 |
Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson’s disease M Meulener, AJ Whitworth, CE Armstrong-Gold, P Rizzu, P Heutink, ... Current Biology 15 (17), 1572-1577, 2005 | 425 | 2005 |
VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations NC Kim, E Tresse, RM Kolaitis, A Molliex, RE Thomas, NH Alami, B Wang, ... Neuron 78 (1), 65-80, 2013 | 261 | 2013 |
Genetic and genomic studies of Drosophila parkin mutants implicate oxidative stress and innate immune responses in pathogenesis JC Greene, AJ Whitworth, LA Andrews, TJ Parker, LJ Pallanck Human molecular genetics 14 (6), 799-811, 2005 | 235 | 2005 |
Cloning and characterization of human and mouse homologs of the Drosophila calcium-activated potassium channel gene, slowpoke L Pallanck, B Ganetzky Human molecular genetics 3 (8), 1239-1243, 1994 | 233 | 1994 |
Ataxin-2 and its Drosophila homolog, ATX2, physically assemble with polyribosomes TF Satterfield, LJ Pallanck Human molecular genetics 15 (16), 2523-2532, 2006 | 231 | 2006 |
Oxidative stress is not a major contributor to somatic mitochondrial DNA mutations LS Itsara, SR Kennedy, EJ Fox, S Yu, JJ Hewitt, M Sanchez-Contreras, ... PLoS genetics 10 (2), e1003974, 2014 | 195 | 2014 |
Induction of the phase II detoxification pathway suppresses neuron loss in Drosophila models of Parkinson's disease K Trinh, K Moore, PD Wes, PJ Muchowski, J Dey, L Andrews, LJ Pallanck Journal of Neuroscience 28 (2), 465-472, 2008 | 182 | 2008 |
PINK1/Parkin mitophagy and neurodegeneration—what do we really know in vivo? AJ Whitworth, LJ Pallanck Current opinion in genetics & development 44, 47-53, 2017 | 170 | 2017 |
A Drosophila Homolog of the Polyglutamine Disease Gene SCA2 Is a Dosage-Sensitive Regulator of Actin Filament Formation TF Satterfield, SM Jackson, LJ Pallanck Genetics 162 (4), 1687-1702, 2002 | 167 | 2002 |
The PINK1/Parkin pathway: a mitochondrial quality control system? AJ Whitworth, LJ Pallanck Journal of bioenergetics and biomembranes 41, 499-503, 2009 | 159 | 2009 |
Drosophila models pioneer a new approach to drug discovery for Parkinson's disease AJ Whitworth, PD Wes, LJ Pallanck Drug discovery today 11 (3-4), 119-126, 2006 | 155 | 2006 |
Parkin: a multipurpose neuroprotective agent? MB Feany, LJ Pallanck Neuron 38 (1), 13-16, 2003 | 153 | 2003 |
Decaffeinated coffee and nicotine-free tobacco provide neuroprotection in Drosophila models of Parkinson's disease through an NRF2-dependent mechanism K Trinh, L Andrews, J Krause, T Hanak, D Lee, M Gelb, L Pallanck Journal of Neuroscience 30 (16), 5525-5532, 2010 | 145 | 2010 |
PINK1-Parkin pathway activity is regulated by degradation of PINK1 in the mitochondrial matrix RE Thomas, LA Andrews, JL Burman, WY Lin, LJ Pallanck PLoS genetics 10 (5), e1004279, 2014 | 142 | 2014 |