The bile acid receptor GPBAR1 regulates the M1/M2 phenotype of intestinal macrophages and activation of GPBAR1 rescues mice from murine colitis M Biagioli, A Carino, S Cipriani, D Francisci, S Marchianò, P Scarpelli, ... The Journal of Immunology 199 (2), 718-733, 2017 | 231 | 2017 |
Bile acids and their receptors in metabolic disorders S Fiorucci, E Distrutti, A Carino, A Zampella, M Biagioli Progress in Lipid Research 82, 101094, 2021 | 150 | 2021 |
Bile acid signaling in inflammatory bowel diseases S Fiorucci, A Carino, M Baldoni, L Santucci, E Costanzi, L Graziosi, ... Digestive Diseases and Sciences 66, 674-693, 2021 | 145 | 2021 |
BAR502, a dual FXR and GPBAR1 agonist, promotes browning of white adipose tissue and reverses liver steatosis and fibrosis A Carino, S Cipriani, S Marchianò, M Biagioli, C Santorelli, A Donini, ... Scientific Reports 7 (1), 42801, 2017 | 117 | 2017 |
Hijacking SARS-CoV-2/ACE2 receptor interaction by natural and semi-synthetic steroidal agents acting on functional pockets on the receptor binding domain A Carino, F Moraca, B Fiorillo, S Marchianò, V Sepe, M Biagioli, ... Frontiers in Chemistry 8, 572885, 2020 | 103 | 2020 |
The bile acid sensor FXR is required for immune-regulatory activities of TLR-9 in intestinal inflammation B Renga, A Mencarelli, S Cipriani, C D'Amore, A Carino, A Bruno, ... PLoS One 8 (1), e54472, 2013 | 99 | 2013 |
Role of TGR5 (GPBAR1) in liver disease V Keitel, D Häussinger Seminars in liver disease 38 (04), 333-339, 2018 | 88 | 2018 |
Exploitation of cholane scaffold for the discovery of potent and selective farnesoid X receptor (FXR) and G-protein coupled bile acid receptor 1 (GP-BAR1) ligands C Festa, B Renga, C D’Amore, V Sepe, C Finamore, S De Marino, ... Journal of medicinal chemistry 57 (20), 8477-8495, 2014 | 87 | 2014 |
Reversal of Endothelial Dysfunction by GPBAR1 Agonism in Portal Hypertension Involves a AKT/FOXOA1 Dependent Regulation of H2S Generation and … B Renga, S Cipriani, A Carino, M Simonetti, A Zampella, S Fiorucci PloS one 10 (11), e0141082, 2015 | 66 | 2015 |
Bile acids activated receptors in inflammatory bowel disease M Biagioli, S Marchianò, A Carino, C Di Giorgio, L Santucci, E Distrutti, ... Cells 10 (6), 1281, 2021 | 59 | 2021 |
The bile acid receptor GPBAR1 (TGR5) is expressed in human gastric cancers and promotes epithelial-mesenchymal transition in gastric cancer cell lines A Carino, L Graziosi, C D'Amore, S Cipriani, S Marchianò, E Marino, ... Oncotarget 7 (38), 61021, 2016 | 56 | 2016 |
Cystathionine γ-lyase, a H2S-generating enzyme, is a GPBAR1-regulated gene and contributes to vasodilation caused by secondary bile acids B Renga, M Bucci, S Cipriani, A Carino, MC Monti, A Zampella, ... American Journal of Physiology-Heart and Circulatory Physiology 309 (1 …, 2015 | 55 | 2015 |
Metabolic variability of a multispecies probiotic preparation impacts on the anti-inflammatory activity M Biagioli, L Laghi, A Carino, S Cipriani, E Distrutti, S Marchianò, ... Frontiers in pharmacology 8, 505, 2017 | 51 | 2017 |
Agonism for the bile acid receptor GPBAR1 reverses liver and vascular damage in a mouse model of steatohepatitis A Carino, S Marchiano, M Biagioli, M Bucci, V Vellecco, V Brancaleone, ... The FASEB Journal 33 (2), 2809-2822, 2019 | 50 | 2019 |
Insights on FXR selective modulation. Speculation on bile acid chemical space in the discovery of potent and selective agonists V Sepe, C Festa, B Renga, A Carino, S Cipriani, C Finamore, D Masullo, ... Scientific reports 6 (1), 19008, 2016 | 50 | 2016 |
Impaired itching perception in murine models of cholestasis is supported by dysregulation of GPBAR1 signaling S Cipriani, B Renga, C D’Amore, M Simonetti, AA De Tursi, A Carino, ... PLoS One 10 (7), e0129866, 2015 | 50 | 2015 |
Signaling from intestine to the host: how bile acids regulate intestinal and liver immunity M Biagioli, A Carino Bile Acids and Their Receptors, 95-108, 2019 | 48 | 2019 |
Gpbar1 agonism promotes a Pgc-1α-dependent browning of white adipose tissue and energy expenditure and reverses diet-induced steatohepatitis in mice A Carino, S Cipriani, S Marchianò, M Biagioli, P Scarpelli, A Zampella, ... Scientific reports 7 (1), 13689, 2017 | 47 | 2017 |
Ursodeoxycholic acid is a GPBAR1 agonist and resets liver/intestinal FXR signaling in a model of diet-induced dysbiosis and NASH A Carino, M Biagioli, S Marchianò, C Fiorucci, A Zampella, MC Monti, ... Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids …, 2019 | 44 | 2019 |
GPBAR1 functions as gatekeeper for liver NKT cells and provides counterregulatory signals in mouse models of immune-mediated hepatitis M Biagioli, A Carino, C Fiorucci, S Marchianò, C Di Giorgio, R Roselli, ... Cellular and Molecular Gastroenterology and Hepatology 8 (3), 447-473, 2019 | 44 | 2019 |