| Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide CJ Wu, JT Jan, CM Chen, HP Hsieh, DR Hwang, HW Liu, CY Liu, ... Antimicrobial agents and chemotherapy 48 (7), 2693-2696, 2004 | 278 | 2004 |
| BPR0L075, a novel synthetic indole compound with antimitotic activity in human cancer cells, exerts effective antitumoral activity in vivo CC Kuo, HP Hsieh, WY Pan, CP Chen, JP Liou, SJ Lee, YL Chang, ... Cancer research 64 (13), 4621-4628, 2004 | 257 | 2004 |
| Concise synthesis and structure− activity relationships of combretastatin A-4 analogues, 1-aroylindoles and 3-aroylindoles, as novel classes of potent antitubulin agents JP Liou, YL Chang, FM Kuo, CW Chang, HY Tseng, CC Wang, YN Yang, ... Journal of medicinal chemistry 47 (17), 4247-4257, 2004 | 228 | 2004 |
| Structure-based drug design and structural biology study of novel nonpeptide inhibitors of severe acute respiratory syndrome coronavirus main protease IL Lu, N Mahindroo, PH Liang, YH Peng, CJ Kuo, KC Tsai, HP Hsieh, ... Journal of medicinal chemistry 49 (17), 5154-5161, 2006 | 183 | 2006 |
| Pharmaceutical design of antimitotic agents based on combretastatins HP Hsieh, JP Liou, N Mahindroo Current pharmaceutical design 11 (13), 1655-1677, 2005 | 183 | 2005 |
| Anti-influenza drug discovery: structure− activity relationship and mechanistic insight into novel angelicin derivatives JY Yeh, MS Coumar, JT Horng, HY Shiao, FM Kuo, HL Lee, IC Chen, ... Journal of medicinal chemistry 53 (4), 1519-1533, 2010 | 177 | 2010 |
| Synthesis and anti-viral activity of a series of sesquiterpene lactones and analogues in the subgenomic HCV replicon system DR Hwang, YS Wu, CW Chang, TW Lien, WC Chen, UK Tan, JTA Hsu, ... Bioorganic & medicinal chemistry 14 (1), 83-91, 2006 | 172 | 2006 |
| Synthesis and structure− activity relationship of 2-aminobenzophenone derivatives as antimitotic agents JP Liou, CW Chang, JS Song, YN Yang, CF Yeh, HY Tseng, YK Lo, ... Journal of medicinal chemistry 45 (12), 2556-2562, 2002 | 155 | 2002 |
| Strategies of development of antiviral agents directed against influenza virus replication HP Hsieh, JTA Hsu Current pharmaceutical design 13 (34), 3531-3542, 2007 | 139 | 2007 |
| Structure-based drug design of a novel family of PPARγ partial agonists: virtual screening, X-ray crystallography, and in vitro/in vivo biological activities IL Lu, CF Huang, YH Peng, YT Lin, HP Hsieh, CT Chen, TW Lien, HJ Lee, ... Journal of medicinal chemistry 49 (9), 2703-2712, 2006 | 134 | 2006 |
| Protein kinase inhibitor design by targeting the Asp-Phe-Gly (DFG) motif: the role of the DFG motif in the design of epidermal growth factor receptor inhibitors YH Peng, HY Shiao, CH Tu, PM Liu, JTA Hsu, PK Amancha, JS Wu, ... Journal of medicinal chemistry 56 (10), 3889-3903, 2013 | 132 | 2013 |
| Pyrazole compound BPR1P0034 with potent and selective anti-influenza virus activity SR Shih, TY Chu, GR Reddy, SN Tseng, HL Chen, WF Tang, M Wu, ... Journal of biomedical science 17, 1-9, 2010 | 130 | 2010 |
| Synthesis and structure− activity relationships of 3-aminobenzophenones as antimitotic agents JP Liou, JY Chang, CW Chang, CY Chang, N Mahindroo, FM Kuo, ... Journal of medicinal chemistry 47 (11), 2897-2905, 2004 | 122 | 2004 |
| Evaluation of metal-conjugated compounds as inhibitors of 3CL protease of SARS-CoV JTA Hsu, CJ Kuo, HP Hsieh, YC Wang, KK Huang, CPC Lin, PF Huang, ... FEBS letters 574 (1-3), 116-120, 2004 | 121 | 2004 |
| Design and Synthesis of Tetrahydropyridothieno[2,3-d]pyrimidine Scaffold Based Epidermal Growth Factor Receptor (EGFR) Kinase Inhibitors: The Role of Side … CH Wu, MS Coumar, CY Chu, WH Lin, YR Chen, CT Chen, HY Shiao, ... Journal of medicinal chemistry 53 (20), 7316-7326, 2010 | 119 | 2010 |
| Synthesis and biological evaluation of 1-methyl-2-(3′, 4′, 5′-trimethoxybenzoyl)-3-aminoindoles as a new class of antimitotic agents and tubulin inhibitors R Romagnoli, PG Baraldi, T Sarkar, MD Carrion, CL Cara, O Cruz-Lopez, ... Journal of medicinal chemistry 51 (5), 1464-1468, 2008 | 119 | 2008 |
| Aurora kinase inhibitors in preclinical and clinical testing CHA Cheung, MS Coumar, HP Hsieh, JY Chang Expert opinion on investigational drugs 18 (4), 379-398, 2009 | 115 | 2009 |
| Aurintricarboxylic acid inhibits influenza virus neuraminidase HC Hung, CP Tseng, JM Yang, YW Ju, SN Tseng, YF Chen, YS Chao, ... Antiviral Research 81 (2), 123-131, 2009 | 115 | 2009 |
| Novel indole-based peroxisome proliferator-activated receptor agonists: design, SAR, structural biology, and biological activities N Mahindroo, CF Huang, YH Peng, CC Wang, CC Liao, TW Lien, ... Journal of medicinal chemistry 48 (26), 8194-8208, 2005 | 114 | 2005 |
| Bortezomib overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance in hepatocellular carcinoma cells in part through the inhibition of the … KF Chen, PY Yeh, C Hsu, CH Hsu, YS Lu, HP Hsieh, PJ Chen, AL Cheng Journal of Biological Chemistry 284 (17), 11121-11133, 2009 | 110 | 2009 |
