Purification of a rat neurotensin receptor expressed in Escherichia coli J TUCKER, R GRISSHAMMER Biochemical Journal 317 (3), 891-899, 1996 | 316 | 1996 |
Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor TG Davies, J Bentley, CE Arris, FT Boyle, NJ Curtin, JA Endicott, ... Nature structural biology 9 (10), 745-749, 2002 | 283 | 2002 |
Design and synthesis of novel lactate dehydrogenase A inhibitors by fragment-based lead generation RA Ward, C Brassington, AL Breeze, A Caputo, S Critchlow, G Davies, ... Journal of medicinal chemistry 55 (7), 3285-3306, 2012 | 184 | 2012 |
Cyclin-dependent kinases: inhibition and substrate recognition JA Endicott, MEM Noble, JA Tucker Current opinion in structural biology 9 (6), 738-744, 1999 | 162 | 1999 |
Discovery of novel potent and highly selective glycogen synthase kinase-3β (GSK3β) inhibitors for Alzheimer’s disease: design, synthesis, and characterization of pyrazines S Berg, M Bergh, S Hellberg, K Högdin, Y Lo-Alfredsson, P Söderman, ... Journal of medicinal chemistry 55 (21), 9107-9119, 2012 | 149 | 2012 |
Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations S Wilmes, M Hafer, J Vuorio, JA Tucker, H Winkelmann, S Löchte, ... Science 367 (6478), 643-652, 2020 | 141 | 2020 |
First-in-class chemical probes against poly (ADP-ribose) glycohydrolase (PARG) inhibit DNA repair with differential pharmacology to olaparib DI James, KM Smith, AM Jordan, EE Fairweather, LA Griffiths, ... ACS chemical biology 11 (11), 3179-3190, 2016 | 136 | 2016 |
Small molecule binding sites on the Ras: SOS complex can be exploited for inhibition of Ras activation JJG Winter, M Anderson, K Blades, C Brassington, AL Breeze, C Chresta, ... Journal of medicinal chemistry 58 (5), 2265-2274, 2015 | 135 | 2015 |
How tyrosine 15 phosphorylation inhibits the activity of cyclin-dependent kinase 2-cyclin A JPI Welburn, JA Tucker, T Johnson, L Lindert, M Morgan, A Willis, ... Journal of Biological Chemistry 282 (5), 3173-3181, 2007 | 128 | 2007 |
Cyclin-dependent kinase 4 inhibitors as a treatment for cancer. Part 1: identification and optimisation of substituted 4, 6-bis anilino pyrimidines JF Beattie, GA Breault, RPA Ellston, S Green, PJ Jewsbury, CJ Midgley, ... Bioorganic & medicinal chemistry letters 13 (18), 2955-2960, 2003 | 111 | 2003 |
Structure-based design of protein tyrosine phosphatase-1B inhibitors E Black, J Breed, AL Breeze, K Embrey, R Garcia, TW Gero, L Godfrey, ... Bioorganic & medicinal chemistry letters 15 (10), 2503-2507, 2005 | 110 | 2005 |
Crystal structure of human thymidine phosphorylase in complex with a small molecule inhibitor RA Norman, ST Barry, M Bate, J Breed, JG Colls, RJ Ernill, RWA Luke, ... Structure 12 (1), 75-84, 2004 | 109 | 2004 |
Probing the ATP Ribose-Binding Domain of Cyclin-Dependent Kinases 1 and 2 with O6-Substituted Guanine Derivatives AE Gibson, CE Arris, J Bentley, FT Boyle, NJ Curtin, TG Davies, ... Journal of medicinal chemistry 45 (16), 3381-3393, 2002 | 109 | 2002 |
Structural insights into FGFR kinase isoform selectivity: diverse binding modes of AZD4547 and ponatinib in complex with FGFR1 and FGFR4 JA Tucker, T Klein, J Breed, AL Breeze, R Overman, C Phillips, ... Structure 22 (12), 1764-1774, 2014 | 108 | 2014 |
Imidazo [1, 2-b] pyridazines: a potent and selective class of cyclin-dependent kinase inhibitors KF Byth, N Cooper, JD Culshaw, DW Heaton, SE Oakes, CA Minshull, ... Bioorganic & medicinal chemistry letters 14 (9), 2249-2252, 2004 | 93 | 2004 |
Quantitative evaluation of neurotensin receptor purification by immobilized metal affinity chromatography R Grisshammer, J Tucker Protein expression and purification 11 (1), 53-60, 1997 | 93 | 1997 |
Aminopyrazinamides: Novel and Specific GyrB Inhibitors that Kill Replicating and Nonreplicating Mycobacterium tuberculosis PS Shirude, P Madhavapeddi, JA Tucker, K Murugan, V Patil, ... ACS chemical biology 8 (3), 519-523, 2013 | 91 | 2013 |
Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR1 kinase T Klein, N Vajpai, JJ Phillips, G Davies, GA Holdgate, C Phillips, ... Nature communications 6 (1), 7877, 2015 | 75 | 2015 |
Thiazolopyridine ureas as novel antitubercular agents acting through inhibition of DNA gyrase B MG Kale, A Raichurkar, SH P, D Waterson, D McKinney, MR Manjunatha, ... Journal of medicinal chemistry 56 (21), 8834-8848, 2013 | 67 | 2013 |
Cyclin-dependent kinase 4 inhibitors as a treatment for cancer. Part 2: identification and optimisation of substituted 2, 4-bis anilino pyrimidines GA Breault, RPA Ellston, S Green, SR James, PJ Jewsbury, CJ Midgley, ... Bioorganic & medicinal chemistry letters 13 (18), 2961-2966, 2003 | 64 | 2003 |