Deubiquitinating enzyme USP30 maintains basal peroxisome abundance by regulating pexophagy V Riccio, N Demers, R Hua, M Vissa, DT Cheng, AW Strilchuk, Y Wang, ... Journal of Cell Biology 218 (3), 798-807, 2019 | 61 | 2019 |
Comparison of DLin-MC3-DMA and ALC-0315 for siRNA delivery to hepatocytes and hepatic stellate cells F Ferraresso, AW Strilchuk, LJ Juang, LG Poole, JP Luyendyk, CJ Kastrup Molecular pharmaceutics 19 (7), 2175-2182, 2022 | 37 | 2022 |
Sustained depletion of FXIII-A by inducing acquired FXIII-B deficiency AW Strilchuk, SC Meixner, J Leung, NS Safikhan, JA Kulkarni, HM Russell, ... Blood, The Journal of the American Society of Hematology 136 (25), 2946-2954, 2020 | 24 | 2020 |
Suppression of fibrin (ogen)-driven pathologies in disease models through controlled knockdown by lipid nanoparticle delivery of siRNA LJ Juang, WS Hur, LM Silva, AW Strilchuk, B Francisco, J Leung, ... Blood, The Journal of the American Society of Hematology 139 (9), 1302-1311, 2022 | 16 | 2022 |
The ubiquitin interacting motifs of USP37 act on the proximal Ub of a di-Ub chain to enhance catalytic efficiency N Manczyk, G Veggiani, J Teyra, AW Strilchuk, SS Sidhu, F Sicheri Scientific Reports 9 (1), 4119, 2019 | 13 | 2019 |
Bleeding is increased in amyloid precursor protein knockout mouse N Mazinani, AW Strilchuk, JR Baylis, WS Hur, WA Jefferies, CJ Kastrup Research and Practice in Thrombosis and Haemostasis 4 (5), 823-828, 2020 | 5 | 2020 |
Nanomedicines for hemorrhage control MF Cau, AW Strilchuk, CJ Kastrup Journal of Thrombosis and Haemostasis 19 (4), 887-891, 2021 | 4 | 2021 |
Lipid nanoparticles and siRNA targeting plasminogen provide lasting inhibition of fibrinolysis in mouse and dog models of hemophilia A AW Strilchuk, WS Hur, P Batty, Y Sang, SR Abrahams, ASM Yong, ... Science Translational Medicine 16 (735), eadh0027, 2024 | 3 | 2024 |
Methods and compositions for modulating plasminogen CJ Kastrup, AW Strilchuk, J Leung, PR Cullis, M Robertson US Patent App. 18/546,414, 2024 | | 2024 |
OC 53.4 An siRNA Gene Therapy to Modulate Circulating Plasminogen Activator Inhibitor 1 F Ferraresso, W Hur, L Juang, A Strilchuk, M Flick, C Kastrup Research and Practice in Thrombosis and Haemostasis 7, 2023 | | 2023 |
A LIBRARY OF SIRNA LIPID NANOPARTICLES THAT KNOCKDOWN SPECIFIC PRO-AND ANTI-FIBRINOLYTIC PROTEINS IN ANIMAL MODELS OF THROMBOSIS AND BLEEDING. F Ferraresso, LJ Juang, A Strilchuk, C Kastrup AMERICAN JOURNAL OF HEMATOLOGY 98, E35-E36, 2023 | | 2023 |
Modulating clot stability by regulating lysis with lipid nanoparticle-delivered siRNA AW Strilchuk UNIVERSITY OF BRITISH COLUMBIA (Vancouver, 2022 | | 2022 |
Developing Transient Gene Therapies to Decrease the Stability of Thrombi for Coagulopathy and Thrombosis AW Strilchuk, C Kastrup, JS Palumbo, P Cullis Blood 136, 27, 2020 | | 2020 |
The Centre for Bl oo d Research F Ferraresso, AW Strilchuk, LJ Juang, LG Poole, JP Luyendyk, CJ Kastrup | | |