| The mechanism of topoisomerase I poisoning by a camptothecin analog BL Staker, K Hjerrild, MD Feese, CA Behnke, AB Burgin Jr, L Stewart Proceedings of the National Academy of Sciences 99 (24), 15387-15392, 2002 | 960 | 2002 |
| ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis P Towler, B Staker, SG Prasad, S Menon, J Tang, T Parsons, D Ryan, ... Journal of Biological Chemistry 279 (17), 17996-18007, 2004 | 776 | 2004 |
| Structures of three classes of anticancer agents bound to the human topoisomerase I− DNA covalent complex BL Staker, MD Feese, M Cushman, Y Pommier, D Zembower, L Stewart, ... Journal of medicinal chemistry 48 (7), 2336-2345, 2005 | 583 | 2005 |
| Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety AB Burgin, OT Magnusson, J Singh, P Witte, BL Staker, JM Bjornsson, ... Nature biotechnology 28 (1), 63-70, 2010 | 415 | 2010 |
| Specific Btk inhibition suppresses B cell–and myeloid cell–mediated arthritis JA Di Paolo, T Huang, M Balazs, J Barbosa, KH Barck, BJ Bravo, ... Nature chemical biology 7 (1), 41-50, 2011 | 385 | 2011 |
| Biological and structural characterization of a host-adapting amino acid in influenza virus S Yamada, M Hatta, BL Staker, S Watanabe, M Imai, K Shinya, ... PLoS pathogens 6 (8), e1001034, 2010 | 356 | 2010 |
| RNA methylation under heat shock control H Bügl, EB Fauman, BL Staker, F Zheng, SR Kushner, MA Saper, ... Molecular cell 6 (2), 349-360, 2000 | 295 | 2000 |
| A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex C Marchand, S Antony, KW Kohn, M Cushman, A Ioanoviciu, BL Staker, ... Molecular cancer therapeutics 5 (2), 287-295, 2006 | 187 | 2006 |
| Mechanisms of camptothecin resistance by human topoisomerase I mutations JE Chrencik, BL Staker, AB Burgin, P Pourquier, Y Pommier, L Stewart, ... Journal of molecular biology 339 (4), 773-784, 2004 | 182 | 2004 |
| DcpS as a therapeutic target for spinal muscular atrophy J Singh, M Salcius, SW Liu, BL Staker, R Mishra, J Thurmond, G Michaud, ... ACS chemical biology 3 (11), 711-722, 2008 | 145 | 2008 |
| Combining functional and structural genomics to sample the essential Burkholderia structome L Baugh, LA Gallagher, R Patrapuvich, MC Clifton, AS Gardberg, ... PloS one 8 (1), e53851, 2013 | 140 | 2013 |
| Design, synthesis, and biological evaluation of cytotoxic 11-alkenylindenoisoquinoline topoisomerase I inhibitors and indenoisoquinoline− camptothecin hybrids BM Fox, X Xiao, S Antony, G Kohlhagen, Y Pommier, BL Staker, L Stewart, ... Journal of medicinal chemistry 46 (15), 3275-3282, 2003 | 131 | 2003 |
| Synthesis and mechanism of action studies of a series of norindenoisoquinoline topoisomerase I poisons reveal an inhibitor with a flipped orientation in the ternary DNA− enzyme … A Ioanoviciu, S Antony, Y Pommier, BL Staker, L Stewart, M Cushman Journal of medicinal chemistry 48 (15), 4803-4814, 2005 | 129 | 2005 |
| Increasing the structural coverage of tuberculosis drug targets L Baugh, I Phan, DW Begley, MC Clifton, B Armour, DM Dranow, ... Tuberculosis 95 (2), 142-148, 2015 | 122 | 2015 |
| Active site in RrmJ, a heat shock-induced methyltransferase J Hager, BL Staker, H Bugl, U Jakob Journal of Biological Chemistry 277 (44), 41978-41986, 2002 | 114 | 2002 |
| The seattle structural genomics center for infectious disease (SSGCID) PJ Myler, R Stacy, L Stewart, BL Staker, WC Van Voorhis, G Varani, ... Infectious Disorders-Drug Targets (Formerly Current Drug Targets-Infectious …, 2009 | 109 | 2009 |
| The plug-based nanovolume microcapillary protein crystallization system (MPCS) CJ Gerdts, M Elliott, S Lovell, MB Mixon, AJ Napuli, BL Staker, P Nollert, ... Acta Crystallographica Section D: Biological Crystallography 64 (11), 1116-1122, 2008 | 82 | 2008 |
| SAD phasing using iodide ions in a high-throughput structural genomics environment J Abendroth, AS Gardberg, JI Robinson, JS Christensen, BL Staker, ... Journal of structural and functional genomics 12, 83-95, 2011 | 80 | 2011 |
| Analysis of human tyrosyl-DNA phosphodiesterase I catalytic residues AC Raymond, MC Rideout, B Staker, K Hjerrild, AB Burgin Jr Journal of molecular biology 338 (5), 895-906, 2004 | 75 | 2004 |
| Structure of Hsp15 reveals a novel RNA‐binding motif BL Staker, P Korber, JCA Bardwell, MA Saper The EMBO journal, 2000 | 67 | 2000 |
