| Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes SR Romanov, BK Kozakiewicz, CR Holst, MR Stampfer, LM Haupt, ... Nature 409 (6820), 633-637, 2001 | 577 | 2001 |
| Methylation of p16INK4a Promoters Occurs in Vivo in Histologically Normal Human Mammary Epithelia CR Holst, GJ Nuovo, M Esteller, K Chew, SB Baylin, JG Herman, TD Tlsty Cancer research 63 (7), 1596-1601, 2003 | 290 | 2003 |
| A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism E Trotta, PH Bessette, SL Silveria, LK Ely, KM Jude, DT Le, CR Holst, ... Nature medicine 24 (7), 1005-1014, 2018 | 190 | 2018 |
| p16INK4a Prevents Centrosome Dysfunction and Genomic Instability in Primary Cells KM McDermott, J Zhang, CR Holst, BK Kozakiewicz, V Singla, TD Tlsty PLoS biology 4 (3), e51, 2006 | 147 | 2006 |
| Vitamin E hydroquinone is an endogenous regulator of ferroptosis via redox control of 15-lipoxygenase A Hinman, CR Holst, JC Latham, JJ Bruegger, G Ulas, KP McCusker, ... PLoS one 13 (8), e0201369, 2018 | 146 | 2018 |
| Secreted Sulfatases Sulf1 and Sulf2 Have Overlapping yet Essential Roles in Mouse Neonatal Survival CR Holst, H Bou-Reslan, BB Gore, K Wong, D Grant, S Chalasani, ... PloS one 2 (6), e575, 2007 | 146 | 2007 |
| Genetic and epigenetic changes in mammary epithelial cells may mimic early events in carcinogenesis TD Tlsty, YG Crawford, CR Holst, CA Fordyce, J Zhang, K McDermott, ... Journal of mammary gland biology and neoplasia 9, 263-274, 2004 | 105 | 2004 |
| Discovery of XL413, a potent and selective CDC7 inhibitor ES Koltun, AL Tsuhako, DS Brown, N Aay, A Arcalas, V Chan, H Du, ... Bioorganic & medicinal chemistry letters 22 (11), 3727-3731, 2012 | 96 | 2012 |
| Inactivation of p53 function in cultured human mammary epithelial cells turns the telomere-length dependent senescence barrier from agonescence into crisis JC Garbe, CR Holst, E Bassett, TD Tlsty, MR Stampfer Cell Cycle 6 (15), 1927-1936, 2007 | 86 | 2007 |
| p16INK4a modulates p53 in primary human mammary epithelial cells J Zhang, CR Pickering, CR Holst, ML Gauthier, TD Tlsty Cancer research 66 (21), 10325-10331, 2006 | 82 | 2006 |
| Targeting ferroptosis: A novel therapeutic strategy for the treatment of mitochondrial disease-related epilepsy AH Kahn-Kirby, A Amagata, CI Maeder, JJ Mei, S Sideris, Y Kosaka, ... PLoS One 14 (3), e0214250, 2019 | 66 | 2019 |
| Discovery of a novel series of potent and orally bioavailable phosphoinositide 3-kinase γ inhibitors JW Leahy, CA Buhr, HWB Johnson, BG Kim, TG Baik, J Cannoy, ... Journal of Medicinal Chemistry 55 (11), 5467-5482, 2012 | 56 | 2012 |
| Loss of chromosomal integrity in human mammary epithelial cells subsequent to escape from senescence TD Tlsty, SR Romanov, BK Kozakiewicz, CR Holst, LM Haupt, ... Journal of mammary gland biology and neoplasia 6, 235-243, 2001 | 53 | 2001 |
| Characterization of Revertants of unc-93(e1500) in Caenorhabditis elegans Induced by N-ethyl-N-nitrosourea E De Stasio, C Lephoto, L Azuma, C Holst, D Stanislaus, J Uttam Genetics 147 (2), 597-608, 1997 | 50 | 1997 |
| High-content, high-throughput analysis of cell cycle perturbations induced by the HSP90 inhibitor XL888 SK Lyman, SC Crawley, R Gong, JI Adamkewicz, G McGrath, JY Chew, ... PLoS One 6 (3), e17692, 2011 | 42 | 2011 |
| Bi-allelic CCDC47 variants cause a disorder characterized by woolly hair, liver dysfunction, dysmorphic features, and global developmental delay M Morimoto, H Waller-Evans, Z Ammous, X Song, KA Strauss, D Pehlivan, ... The American Journal of Human Genetics 103 (5), 794-807, 2018 | 24 | 2018 |
| Methods and compositions for treatment of inflammation and oxidative stress GM Miller, JK Trimmer, WD Shrader, AW Hinman, CR Holst, JC Latham, ... | 6 | 2018 |
| 2, 3, 5-trimelthyl-6-nonylcyclohexa-2, 5-diene-1, 4-dione for suppressing and treating alpha-synucleinopathies, tauopathies, and other disorders AW Hinman, CR Holst, A Minnella, P Mollard, S Pintchovski, JK Trimmer, ... US Patent 11,174,212, 2021 | 4 | 2021 |
| 2, 3, 5-trimethyl-6-nonylcyclohexa-2, 5-diene-1, 4-dione for suppressing and treating alpha-synucleinopathies, tauopathies, and other disorders AW Hinman, CR Holst, A Minnella, P Mollard, S Pintchovski, JK Trimmer, ... US Patent 11,667,596, 2023 | 2 | 2023 |
| Anti-avb8 antibodies and compositions and uses thereof KS Niessen, D Samuel, CR Holst, MR Drever, D Sheppard, RJ Akhurst, ... US Patent 11,359,024, 2022 | 1 | 2022 |
