Agonist-induced dimer dissociation as a macromolecular step in G protein-coupled receptor signaling J Petersen, SC Wright, D Rodríguez, P Matricon, N Lahav, A Vromen, ... Nature communications 8 (1), 226, 2017 | 81 | 2017 |
Frizzleds as GPCRs–more conventional than we thought! G Schulte, SC Wright Trends in pharmacological sciences 39 (9), 828-842, 2018 | 80 | 2018 |
A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection SC Wright, P Kozielewicz, M Kowalski-Jahn, J Petersen, CF Bowin, ... Nature communications 10 (1), 667, 2019 | 68 | 2019 |
FZD5 is a Gαq-coupled receptor that exhibits the functional hallmarks of prototypical GPCRs SC Wright, MCA Canizal, T Benkel, K Simon, C Le Gouill, P Matricon, ... Science signaling 11 (559), eaar5536, 2018 | 60 | 2018 |
Agonist-induced formation of unproductive receptor-G12 complexes N Okashah, SC Wright, K Kawakami, S Mathiasen, J Zhou, S Lu, ... Proceedings of the National Academy of Sciences 117 (35), 21723-21730, 2020 | 44 | 2020 |
Illuminating the complexity of GPCR pathway selectivity–advances in biosensor development SC Wright, M Bouvier Current Opinion in Structural Biology 69, 142-149, 2021 | 37 | 2021 |
BRET-based effector membrane translocation assay monitors GPCR-promoted and endocytosis-mediated Gq activation at early endosomes SC Wright, V Lukasheva, C Le Gouill, H Kobayashi, B Breton, ... Proceedings of the National Academy of Sciences 118 (20), e2025846118, 2021 | 32 | 2021 |
Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric Gs L Xu, B Chen, H Schihada, SC Wright, A Turku, Y Wu, GW Han, ... Cell research 31 (12), 1311-1314, 2021 | 29 | 2021 |
Barbadin selectively modulates FPR2-mediated neutrophil functions independent of receptor endocytosis M Sundqvist, A Holdfeldt, SC Wright, TC Møller, E Siaw, K Jennbacken, ... Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1867 (12), 118849, 2020 | 20 | 2020 |
GLP-1R signaling neighborhoods associate with the susceptibility to adverse drug reactions of incretin mimetics SC Wright, A Motso, S Koutsilieri, CM Beusch, P Sabatier, A Berghella, ... Nature communications 14 (1), 6243, 2023 | 14 | 2023 |
Organotypic human ex vivo models for coronavirus disease 2019 research and drug development S Youhanna, SC Wright, VM Lauschke Current Opinion in Pharmacology 59, 11-18, 2021 | 5 | 2021 |
Crimean–Congo haemorrhagic fever virus uses LDLR to bind and enter host cells VM Monteil, SC Wright, M Dyczynski, MJ Kellner, S Appelberg, SW Platzer, ... Nature Microbiology 9 (6), 1499-1512, 2024 | 2 | 2024 |
Class Frizzled GPCRs (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database E Arthofer, J Dijksterhuis, B Hot, P Kozielewicz, M Lauth, J Olofsson, ... IUPHAR/BPS Guide to Pharmacology CITE 2019 (4), 2019 | 2 | 2019 |
Rewiring of catecholamine‐induced calcium signalling is an early event in non‐alcoholic fatty liver disease. SC Wright, VM Lauschke Journal of Physiology 601 (8), 2023 | 1 | 2023 |
Altered desensitization and internalization patterns of rodent versus human glucose‐dependent insulinotropic polypeptide (GIP) receptors. An important drug discovery challenge LS Gasbjerg, RS Rasmussen, A Dragan, P Lindquist, JU Melchiorsen, ... British Journal of Pharmacology, 2024 | | 2024 |
Conformation-and activation-based BRET sensors differentially report on GPCR–G protein coupling SC Wright, C Avet, SA Gaitonde, I Muneta-Arrate, C Le Gouill, M Hogue, ... Science Signaling 17 (841), eadi4747, 2024 | | 2024 |
Characterization of genetic variants of GIPR reveals a contribution of β-arrestin to metabolic phenotypes HS Kizilkaya, KV Sørensen, JS Madsen, P Lindquist, JD Douros, ... Nature metabolism, 1-14, 2024 | | 2024 |
The novel adrenergic agonist ATR-127 targets skeletal muscle and brown adipose tissue to tackle diabesity and steatohepatitis E Talamonti, J Davegardh, A Kalinovich, SMM van Beek, N Dehvari, ... Molecular Metabolism, 101931, 2024 | | 2024 |
Discovery of a novel inhibitor of macropinocytosis with antiviral activity B Porebski, W Christ, A Corman, M Haraldsson, M Barz, L Lidemalm, ... Molecular Therapy, 2023 | | 2023 |
Class Frizzled GPCRs in GtoPdb v. 2023.1 E Arthofer, J Dijksterhuis, L Grätz, B Hot, P Kozielewicz, M Lauth, ... IUPHAR/BPS Guide to Pharmacology CITE 2023 (1), 2023 | | 2023 |