Design, synthesis, biological evaluation and in silico studies of novel pyrrolo [3, 4-d] pyridazinone derivatives with promising anti-inflammatory and antioxidant activity Ł Szczukowski, A Redzicka, B Wiatrak, E Krzyżak, A Marciniak, ... Bioorganic Chemistry 102, 104035, 2020 | 30 | 2020 |
Design, Synthesis and Comprehensive Investigations of Pyrrolo[3,4-d]pyridazinone-Based 1,3,4-Oxadiazole as New Class of Selective COX-2 Inhibitors Ł Szczukowski, E Krzyżak, A Zborowska, P Zając, K Potyrak, K Peregrym, ... International Journal of Molecular Sciences 21 (24), 9623, 2020 | 28 | 2020 |
COX-1/COX-2 inhibition activities and molecular docking study of newly designed and synthesized pyrrolo [3, 4-c] pyrrole Mannich bases A Redzicka, Ł Szczukowski, A Kochel, B Wiatrak, K Gębczak, ... Bioorganic & Medicinal Chemistry 27 (17), 3918-3928, 2019 | 25 | 2019 |
The Cu2+ Binding Properties of Branched Peptides Based on l-2,3-Diaminopropionic Acid Ł Szyrwiel, Ł Szczukowski, JS Pap, B Setner, Z Szewczuk, W Malinka Inorganic Chemistry 53 (15), 7951-7959, 2014 | 22 | 2014 |
Effect of Novel Pyrrolo[3,4-d]pyridazinone Derivatives on Lipopolysaccharide-Induced Neuroinflammation K Wakulik, B Wiatrak, Ł Szczukowski, D Bodetko, M Szandruk-Bender, ... International Journal of Molecular Sciences 21 (7), 2575, 2020 | 19 | 2020 |
Novel 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-d]Pyridazinone Exert Anti-Inflammatory Activity without Acute Gastrotoxicity in the Carrageenan-Induced Rat Paw … M Szandruk-Bender, A Merwid-Ląd, B Wiatrak, M Danielewski, S Dzimira, ... Journal of Inflammation Research, 5739-5756, 2021 | 18 | 2021 |
Branched peptide with three histidines for the promotion of Cu II binding in a wide pH range–complementary potentiometric, spectroscopic and electrochemical studies Ł Szyrwiel, JS Pap, Ł Szczukowski, Z Kerner, J Brasuń, B Setner, ... RSC advances 5 (70), 56922-56931, 2015 | 18 | 2015 |
A novel branched TAT47–57 peptide for selective Ni2+ introduction into the human fibrosarcoma cell nucleus Ł Szyrwiel, M Shimura, J Shirataki, S Matsuyama, A Matsunaga, B Setner, ... Metallomics 7 (7), 1155-1162, 2015 | 17 | 2015 |
In Vitro and In Silico Evaluation of New 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-d]pyridazinone as Promising Cyclooxygenase Inhibitors K Peregrym, Ł Szczukowski, B Wiatrak, K Potyrak, Ż Czyżnikowska, ... International Journal of Molecular Sciences 22 (17), 9130, 2021 | 14 | 2021 |
New N-Substituted-1,2,4-triazole Derivatives of Pyrrolo[3,4-d]pyridazinone with Significant Anti-Inflammatory Activity—Design, Synthesis and Complementary In … Ł Szczukowski, E Krzyżak, B Wiatrak, P Jawień, A Marciniak, A Kotynia, ... International Journal of Molecular Sciences 22 (20), 11235, 2021 | 13 | 2021 |
Novel 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-d]pyridazinone Exert Antinociceptive Activity in the Tail-Flick and Formalin Test in Rodents and Reveal Reduced … M Szandruk-Bender, B Wiatrak, Ł Szczukowski, P Świątek, M Rutkowska, ... International Journal of Molecular Sciences 21 (24), 9685, 2020 | 10 | 2020 |
Electrocatalytic water oxidation influenced by the ratio between Cu2+ and a multiply branched peptide ligand Ł Szyrwiel, D Lukács, T Ishikawa, J Brasun, Ł Szczukowski, Z Szewczuk, ... Catalysis Communications 122, 5-9, 2019 | 7 | 2019 |
Targeting Lineage-Specific Transcription Factors and Cytokines of the Th17/Treg Axis by Novel 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-d]pyridazinone … M Szandruk-Bender, B Wiatrak, S Dzimira, A Merwid-Ląd, Ł Szczukowski, ... International Journal of Molecular Sciences 23 (17), 9897, 2022 | 6 | 2022 |
Effect of pyrrolo [3, 4-d] pyridazinone derivatives in neuroinflammation induced by preincubation with lipopolysaccharide or coculturing with microglia-like cells K Potyrak, B Wiatrak, E Krzyżak, Ł Szczukowski, P Świątek, A Szeląg Biomedicine & Pharmacotherapy 141, 111878, 2021 | 4 | 2021 |
Synthesis, Biological, Spectroscopic and Computational Investigations of Novel N-Acylhydrazone Derivatives of Pyrrolo[3,4-d]pyridazinone as Dual COX/LOX … J Mikus, P Świątek, P Przybyła, E Krzyżak, A Marciniak, A Kotynia, ... Molecules 28 (14), 5479, 2023 | 3 | 2023 |
New Triazole-Containing Branched Bis (dipeptidomimetic)–Switching from Self-Dimerization to Anion-Binding Properties TK Chui, HF Chow Synlett 28 (20), 2807-2811, 2017 | 2 | 2017 |
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Anti-Inflammatory and Antioxidant Pyrrolo[3,4-d]pyridazinone Derivatives Interact with DNA and Bind to Plasma Proteins—Spectroscopic and In Silico Studies A Kotynia, E Krzyżak, J Żądło, M Witczak, Ł Szczukowski, J Mucha, ... International Journal of Molecular Sciences 25 (3), 1784, 2024 | | 2024 |
The study of the interaction between pyridazinone derivatives and DNA J Żądło, M Witczak, A Kotynia, E Krzyżak, Ł Szczukowski, P Świątek, ... Advances, 125, 2023 | | 2023 |
Interactions of N-Mannich Bases of Pyrrolo[3,4-c]pyrrole with Artificial Models of Cell Membranes and Plasma Proteins, Evaluation of Anti-Inflammatory and … Ł Szczukowski, J Maniewska, B Wiatrak, P Jawień, E Krzyżak, A Kotynia, ... Membranes 13 (3), 349, 2023 | | 2023 |