关注
Yukun Guan
Yukun Guan
Research Fellow, NIAAA/NIH
在 nih.gov 的电子邮件经过验证
标题
引用次数
引用次数
年份
Manganese increases the sensitivity of the cGAS-STING pathway for double-stranded DNA and is required for the host defense against DNA viruses
C Wang, Y Guan, M Lv, R Zhang, Z Guo, X Wei, X Du, J Yang, T Li, Y Wan, ...
Immunity 48 (4), 675-687. e7, 2018
4402018
Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy
M Lv, M Chen, R Zhang, W Zhang, C Wang, Y Zhang, X Wei, Y Guan, ...
Cell Research, 1-14, 2020
4342020
Activation of STAT6 by STING is critical for antiviral innate immunity
H Chen, H Sun, F You, W Sun, X Zhou, L Chen, J Yang, Y Wang, H Tang, ...
Cell 147 (2), 436-446, 2011
4222011
MAVS activates TBK1 and IKKε through TRAFs in NEMO dependent and independent manner
R Fang, Q Jiang, X Zhou, C Wang, Y Guan, J Tao, J Xi, JM Feng, Z Jiang
PLoS pathogens 13 (11), e1006720, 2017
1842017
Mn2+ directly activates cGAS and structural analysis suggests Mn2+ induces a noncanonical catalytic synthesis of 2′ 3′-cGAMP
Z Zhao, Z Ma, B Wang, Y Guan, XD Su, Z Jiang
Cell reports 32 (7), 2020
1642020
Manganese salts function as potent adjuvants
R Zhang, C Wang, Y Guan, X Wei, M Sha, M Yi, M Jing, M Lv, W Guo, J Xu, ...
Cellular & molecular immunology 18 (5), 1222-1234, 2021
1372021
Golgi apparatus-synthesized sulfated glycosaminoglycans mediate polymerization and activation of the cGAMP sensor STING
R Fang, Q Jiang, Y Guan, P Gao, R Zhang, Z Zhao, Z Jiang
Immunity 54 (5), 962-975. e8, 2021
942021
Distinct histopathological phenotypes of severe alcoholic hepatitis suggest different mechanisms driving liver injury and failure
J Ma, A Guillot, Z Yang, B Mackowiak, S Hwang, O Park, BJ Peiffer, ...
The Journal of Clinical Investigation 132 (14), 2022
352022
E-selectin-dependent inflammation and lipolysis in adipose tissue exacerbate steatosis-to-NASH progression via S100A8/9
RM Rodrigues, Y He, S Hwang, A Bertola, B Mackowiak, YA Ahmed, ...
Cellular and molecular gastroenterology and hepatology 13 (1), 151-171, 2022
302022
NLRP6 self-assembles into a linear molecular platform following LPS binding and ATP stimulation
F Leng, H Yin, S Qin, K Zhang, Y Guan, R Fang, H Wang, G Li, Z Jiang, ...
Scientific Reports 10 (1), 198, 2020
302020
Kupffer cell restoration after partial hepatectomy is mainly driven by local cell proliferation in IL-6-dependent autocrine and paracrine manners
Y Ait Ahmed, Y Fu, RM Rodrigues, Y He, Y Guan, A Guillot, R Ren, ...
Cellular & molecular immunology 18 (9), 2165-2176, 2021
262021
MicroRNA-223 attenuates hepatocarcinogenesis by blocking hypoxia-driven angiogenesis and immunosuppression
Y Fu, B Mackowiak, D Feng, H Lu, Y Guan, T Lehner, H Pan, XW Wang, ...
Gut 72 (10), 1942-1958, 2023
252023
Ethanol and its nonoxidative metabolites promote acute liver injury by inducing ER stress, adipocyte death, and lipolysis
SH Park, W Seo, MJ Xu, B Mackowiak, Y Lin, Y He, Y Fu, S Hwang, ...
Cellular and molecular gastroenterology and hepatology 15 (2), 281-306, 2023
182023
Monocyte-derived macrophages orchestrate multiple cell-type interactions to repair necrotic liver lesions in disease models
D Feng, X Xiang, Y Guan, A Guillot, H Lu, C Chang, Y He, H Wang, H Pan, ...
The Journal of Clinical Investigation 133 (15), 2023
142023
Targeting adipose tissue to tackle NASH: SPARCL1 as an emerging player
RM Rodrigues, Y Guan, B Gao
The Journal of Clinical Investigation 131 (20), 2021
122021
The manganese salt (MnJ) functions as a potent universal adjuvant
R Zhang, C Wang, Y Guan, X Wei, M Sha, M Jing, M Lv, J Xu, Y Wan, ...
Biorxiv, 783910, 2019
42019
IL-8+ neutrophils drive inexorable inflammation in severe alcohol-associated hepatitis
Y Guan, B Peiffer, D Feng, MA Parra, Y Wang, Y Fu, VH Shah, ...
The Journal of Clinical Investigation 134 (9), 2024
32024
Deletion of adipocyte prohibitin 1 exacerbates high‐fat diet‐induced steatosis but not liver inflammation and fibrosis
X Wang, SJ Kim, Y Guan, R Parker, RM Rodrigues, D Feng, SC Lu, B Gao
Hepatology communications 6 (12), 3335-3348, 2022
32022
Hepatic CYP2B10 is highly induced by binge ethanol and contributes to acute‐on‐chronic alcohol‐induced liver injury
B Mackowiak, M Xu, Y Lin, Y Guan, W Seo, R Ren, D Feng, JW Jones, ...
Alcoholism: Clinical and Experimental Research 46 (12), 2163-2176, 2022
22022
Pathogenic ILC1 and NKp46+ ILC3 Are Defined by Core and Tissue-Specific Transcriptional Signatures in Autoimmune Neuroinflammation
CA Spinner, Y Guan, Y Fan, A Magen, T Ciucci, R Bosselut, ...
The Journal of Immunology 206 (1_Supplement), 60.06-60.06, 2021
12021
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