The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses EM Smith, SG Finn, AR Tee, GJ Browne, CG Proud Journal of Biological Chemistry 280 (19), 18717-18727, 2005 | 480 | 2005 |
Regulation of miRNA strand selection: follow the leader? HA Meijer, EM Smith, M Bushell Biochemical Society Transactions 42 (4), 1135-1140, 2014 | 315 | 2014 |
PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex BD Fonseca, EM Smith, VHY Lee, C MacKintosh, CG Proud Journal of Biological Chemistry 282 (34), 24514-24524, 2007 | 299 | 2007 |
Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice M Halliday, H Radford, KAM Zents, C Molloy, JA Moreno, NC Verity, ... Brain 140 (6), 1768-1783, 2017 | 294 | 2017 |
La-related protein 1 (LARP1) represses terminal oligopyrimidine (TOP) mRNA translation downstream of mTOR complex 1 (mTORC1) BD Fonseca, C Zakaria, JJ Jia, TE Graber, Y Svitkin, S Tahmasebi, ... Journal of Biological Chemistry 290 (26), 15996-16020, 2015 | 276 | 2015 |
Drosha drives the formation of DNA: RNA hybrids around DNA break sites to facilitate DNA repair WT Lu, BR Hawley, GL Skalka, RA Baldock, EM Smith, AS Bader, ... Nature communications 9 (1), 532, 2018 | 207 | 2018 |
The ever-evolving role of mTOR in translation BD Fonseca, EM Smith, N Yelle, T Alain, M Bushell, A Pause Seminars in cell & developmental biology 36, 102-112, 2014 | 128 | 2014 |
Differential control of Eg5‐dependent centrosome separation by Plk1 and Cdk1 E Smith, N Hégarat, C Vesely, I Roseboom, C Larch, H Streicher, ... The EMBO journal 30 (11), 2233-2245, 2011 | 125 | 2011 |
cdc2–cyclin B regulates eEF2 kinase activity in a cell cycle‐and amino acid‐dependent manner EM Smith, CG Proud The EMBO journal 27 (7), 1005-1016, 2008 | 117 | 2008 |
Aurora A and Aurora B jointly coordinate chromosome segregation and anaphase microtubule dynamics N Hégarat, E Smith, G Nayak, S Takeda, PA Eyers, H Hochegger Journal of Cell Biology 195 (7), 1103-1113, 2011 | 87 | 2011 |
The diverse roles of the eIF4A family: you are the company you keep WT Lu, A Wilczynska, E Smith, M Bushell Biochemical Society Transactions 42 (1), 166-172, 2014 | 76 | 2014 |
mTORC1 promotes TOP mRNA translation through site-specific phosphorylation of LARP1 JJ Jia, RM Lahr, MT Solgaard, BJ Moraes, R Pointet, AD Yang, G Celucci, ... Nucleic acids research 49 (6), 3461-3489, 2021 | 70 | 2021 |
MNK Inhibition Sensitizes KRAS-Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression JRP Knight, C Alexandrou, GL Skalka, N Vlahov, K Pennel, L Officer, ... Cancer discovery 11 (5), 1228-1247, 2021 | 57 | 2021 |
Identification of autophosphorylation sites in eukaryotic elongation factor-2 kinase S Pyr Dit Ruys, X Wang, EM Smith, G Herinckx, N Hussain, MH Rider, ... Biochemical Journal 442 (3), 681-692, 2012 | 54 | 2012 |
Oxidized LDL-mediated macrophage survival involves elongation factor-2 kinase JH Chen, M Riazy, EM Smith, CG Proud, UP Steinbrecher, V Duronio Arteriosclerosis, thrombosis, and vascular biology 29 (1), 92-98, 2009 | 49 | 2009 |
Centrosome amplification in CHO and DT40 cells by inactivation of cyclin‐dependent kinases N Steere, M Wagner, S Beishir, E Smith, L Breslin, CG Morrison, ... Cytoskeleton 68 (8), 446-458, 2011 | 32 | 2011 |
The mTOR regulated RNA-binding protein LARP1 requires PABPC1 for guided mRNA interaction EM Smith, NEH Benbahouche, K Morris, A Wilczynska, S Gillen, ... Nucleic acids research 49 (1), 458-478, 2021 | 28 | 2021 |
Short stretches of rare codons regulate translation of the transcription factor ZEB2 in cancer cells WR Wan Makhtar, G Browne, A Karountzos, C Stevens, Y Alghamdi, ... Oncogene 36 (47), 6640-6648, 2017 | 25 | 2017 |
LARP1 is a major phosphorylation substrate of mTORC1 BD Fonseca, JJ Jia, AK Hollensen, R Pointet, HD Hoang, MR Niklaus, ... BioRxiv, 491274, 2018 | 15 | 2018 |
Parallel evolution of semicircular canal form and sensitivity in subterranean mammals J Goyens, S Baeckens, ESJ Smith, J Pozzi, MJ Mason Journal of Comparative Physiology A 208 (5), 627-640, 2022 | 2 | 2022 |