| Oxidants, antioxidants, and the degenerative diseases of aging. BN Ames, MK Shigenaga, TM Hagen Proceedings of the National Academy of Sciences 90 (17), 7915-7922, 1993 | 9733 | 1993 |
| Oxidative damage and mitochondrial decay in aging. MK Shigenaga, TM Hagen, BN Ames Proceedings of the National Academy of Sciences 91 (23), 10771-10778, 1994 | 2829 | 1994 |
| Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential KP Shay, RF Moreau, EJ Smith, AR Smith, TM Hagen Biochimica et Biophysica Acta (BBA)-General Subjects 1790 (10), 1149-1160, 2009 | 1261 | 2009 |
| Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid JH Suh, SV Shenvi, BM Dixon, H Liu, AK Jaiswal, RM Liu, TM Hagen Proceedings of the National Academy of Sciences 101 (10), 3381-3386, 2004 | 925 | 2004 |
| Selective fluorescent imaging of superoxide in vivo using ethidium-based probes KM Robinson, MS Janes, M Pehar, JS Monette, MF Ross, TM Hagen, ... Proceedings of the National Academy of Sciences 103 (41), 15038-15043, 2006 | 885 | 2006 |
| Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: Partial reversal by feeding acetyl-l-carnitine and/or R-α-lipoic acid J Liu, E Head, AM Gharib, W Yuan, RT Ingersoll, TM Hagen, CW Cotman, ... Proceedings of the National Academy of Sciences 99 (4), 2356-2361, 2002 | 726 | 2002 |
| Chronically and acutely exercised rats: biomarkers of oxidative stress and endogenous antioxidants J Liu, HC Yeo, E Overvik-Douki, T Hagen, SJ Doniger, DW Chu, ... Journal of applied physiology 89 (1), 21-28, 2000 | 682 | 2000 |
| Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress AR Smith, SV Shenvi, M Widlansky, JH Suh, TM Hagen Current medicinal chemistry 11 (9), 1135-1146, 2004 | 673 | 2004 |
| Mitochondrial decay in hepatocytes from old rats: membrane potential declines, heterogeneity and oxidants increase TM Hagen, DL Yowe, JC Bartholomew, CM Wehr, KL Do, JY Park, ... Proceedings of the National Academy of Sciences 94 (7), 3064-3069, 1997 | 575 | 1997 |
| Mitochondrial decay in aging BN Ames, MK Shigenaga, TM Hagen Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1271 (1), 165-170, 1995 | 536 | 1995 |
| Feeding acetyl-l-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress TM Hagen, J Liu, J Lykkesfeldt, CM Wehr, RT Ingersoll, V Vinarsky, ... Proceedings of the National Academy of sciences 99 (4), 1870-1875, 2002 | 488 | 2002 |
| Extensive oxidative DNA damage in hepatocytes of transgenic mice with chronic active hepatitis destined to develop hepatocellular carcinoma. TM Hagen, S Huang, J Curnutte, P Fowler, V Martinez, CM Wehr, ... Proceedings of the National Academy of Sciences 91 (26), 12808-12812, 1994 | 406 | 1994 |
| Acetyl-l-carnitine fed to old rats partially restores mitochondrial function and ambulatory activity TM Hagen, RT Ingersoll, CM Wehr, J Lykkesfeldt, V Vinarsky, ... Proceedings of the National Academy of Sciences 95 (16), 9562-9566, 1998 | 359 | 1998 |
| Age‐associated increases in oxidative stress and antioxidant enzyme activities in cardiac interfibrillar mitochondria: implications for the mitochondrial theory of aging S Judge, YM Jang, A Smith, T Hagen, C Leeuwenburgh The FASEB journal 19 (3), 1-21, 2005 | 357 | 2005 |
| α-Lipoic acid attenuates LPS-induced inflammatory responses by activating the phosphoinositide 3-kinase/Akt signaling pathway WJ Zhang, H Wei, T Hagen, B Frei Proceedings of the National Academy of Sciences 104 (10), 4077-4082, 2007 | 332 | 2007 |
| Glutathione metabolism during aging and in Alzheimer disease H Liu, H Wang, S Shenvi, TM Hagen, RUIM LIU Annals of the New York Academy of Sciences 1019 (1), 346-349, 2004 | 320 | 2004 |
| (R)‐α‐Lipoic acid‐supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate TM Hagen, RT Ingersoll, J Lykkesfeldt, J LIU, CM WEHR, V VINARSKY, ... The FASEB journal 13 (2), 411-418, 1999 | 316 | 1999 |
| Exogenous glutathione protects intestinal epithelial cells from oxidative injury. LH Lash, TM Hagen, DP Jones Proceedings of the National Academy of Sciences 83 (13), 4641-4645, 1986 | 268 | 1986 |
| Oxidative damage increases with age in a canine model of human brain aging E Head, J Liu, TM Hagen, BA Muggenburg, NW Milgram, BN Ames, ... Journal of neurochemistry 82 (2), 375-381, 2002 | 260 | 2002 |
| Is α‐lipoic acid a scavenger of reactive oxygen species in vivo? Evidence for its initiation of stress signaling pathways that promote endogenous antioxidant capacity K Petersen Shay, RF Moreau, EJ Smith, TM Hagen IUBMB life 60 (6), 362-367, 2008 | 236 | 2008 |
