Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury W Tonnus, C Meyer, C Steinebach, A Belavgeni, A von Mässenhausen, ... Nature communications 12 (1), 1-14, 2021 | 159 | 2021 |
Homo-PROTACs for the chemical knockdown of cereblon C Steinebach, S Lindner, ND Udeshi, DC Mani, H Kehm, S Köpff, ... ACS chemical biology 13 (9), 2771-2782, 2018 | 139 | 2018 |
E3 Ligase Ligands in Successful PROTACs: An Overview of Syntheses and Linker Attachment Points A Bricelj, C Steinebach, R Kuchta, M Gütschow, I Sosič Frontiers in Chemistry 9, 463, 2021 | 128 | 2021 |
Systematic exploration of different E3 ubiquitin ligases: an approach towards potent and selective CDK6 degraders C Steinebach, YLD Ng, I Sosič, CS Lee, S Chen, S Lindner, LP Vu, ... Chemical Science 11 (13), 3474-3486, 2020 | 101 | 2020 |
PROTAC-mediated crosstalk between E3 ligases C Steinebach, H Kehm, S Lindner, LP Vu, S Köpff, ÁL Mármol, C Weiler, ... Chemical Communications 55 (12), 1821-1824, 2019 | 95 | 2019 |
E3 ligase ligand chemistries: from building blocks to protein degraders I Sosič, A Bricelj, C Steinebach Chemical Society Reviews, 2022 | 66 | 2022 |
A MedChem toolbox for cereblon-directed PROTACs C Steinebach, I Sosič, S Lindner, A Bricelj, F Kohl, YLD Ng, M Monschke, ... MedChemComm 10 (6), 1037-1041, 2019 | 56 | 2019 |
Proteomic profiling reveals CDK6 upregulation as a targetable resistance mechanism for lenalidomide in multiple myeloma YLD Ng, E Ramberger, SR Bohl, A Dolnik, C Steinebach, T Conrad, ... Nature Communications 13 (1), 1-13, 2022 | 38 | 2022 |
Influence of Linker Attachment Points on the Stability and Neosubstrate Degradation of Cereblon Ligands A Bricelj, YL Dora Ng, D Ferber, R Kuchta, S Müller, M Monschke, ... ACS Medicinal Chemistry Letters, 2021 | 36 | 2021 |
Lenalidomide and pomalidomide potently interfere with induction of myeloid‐derived suppressor cells in multiple myeloma S Kuwahara‐Ota, Y Shimura, C Steinebach, R Isa, J Yamaguchi, ... British Journal of Haematology 191 (5), 784-795, 2020 | 31 | 2020 |
Development of the first non-hydroxamate selective HDAC6 degraders T Keuler, B König, N Bückreiß, F Kraft, P König, L Schäker-Hübner, ... Chemical Communications, 2022 | 24 | 2022 |
A Facile Synthesis of Ligands for the von Hippel–Lindau E3 Ligase C Steinebach, SA Voell, LP Vu, A Bricelj, I Sosič, G Schnakenburg, ... Synthesis 52 (17), 2521-2527, 2020 | 24 | 2020 |
Targeting the deubiquitinase USP7 for degradation with PROTACs A Murgai, I Sosič, M Gobec, P Lemnitzer, M Proj, S Wittenburg, R Voget, ... Chemical Communications 58 (63), 8858-8861, 2022 | 23 | 2022 |
Chemical inactivation of the E3 ubiquitin ligase cereblon by pomalidomide-based homo-PROTACs S Lindner, C Steinebach, H Kehm, M Mangold, M Gütschow, J Krönke JoVE (Journal of Visualized Experiments), e59472, 2019 | 22 | 2019 |
Design, synthesis, and characterization of PROTACs targeting the androgen receptor in prostate and lung cancer models LM Gockel, V Pfeifer, F Baltes, RD Bachmaier, KG Wagner, G Bendas, ... Archiv der Pharmazie, e202100467, 2022 | 15 | 2022 |
Antiangiogenic Activity and in Silico Cereblon Binding Analysis of Novel Thalidomide Analogs ML Peach, SL Beedie, CH Chau, MK Collins, S Markolovic, W Luo, ... Molecules 25 (23), 5683, 2020 | 15 | 2020 |
On the correlation of cereblon binding, fluorination and antiangiogenic properties of immunomodulatory drugs C Heim, S Maiwald, C Steinebach, MK Collins, J Strope, CH Chau, ... Biochemical and Biophysical Research Communications 534, 67-72, 2020 | 14 | 2020 |
Solubility and Stability Enhanced Oral Formulations for the Anti-Infective Corallopyronin A AK Krome, T Becker, S Kehraus, A Schiefer, C Steinebach, T Aden, ... Pharmaceutics 12 (11), 1105, 2020 | 13 | 2020 |
Solubility Enhanced Formulation Approaches to Overcome Oral Delivery Obstacles of PROTACs F Pöstges, K Kayser, J Appelhaus, M Monschke, M Gütschow, ... Pharmaceutics 15 (1), 156, 2023 | 12 | 2023 |
Synthesis and antiangiogenic properties of tetrafluorophthalimido and tetrafluorobenzamido barbituric acids A Ambrożak, C Steinebach, ER Gardner, SL Beedie, G Schnakenburg, ... ChemMedChem 11 (23), 2621, 2016 | 12 | 2016 |