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Christian Steinebach
Christian Steinebach
Postdoctoral Researcher, Pharmaceutical Institute, University of Bonn
在 uni-bonn.de 的电子邮件经过验证 - 首页
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引用次数
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年份
Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury
W Tonnus, C Meyer, C Steinebach, A Belavgeni, A von Mässenhausen, ...
Nature communications 12 (1), 1-14, 2021
1592021
Homo-PROTACs for the chemical knockdown of cereblon
C Steinebach, S Lindner, ND Udeshi, DC Mani, H Kehm, S Köpff, ...
ACS chemical biology 13 (9), 2771-2782, 2018
1392018
E3 Ligase Ligands in Successful PROTACs: An Overview of Syntheses and Linker Attachment Points
A Bricelj, C Steinebach, R Kuchta, M Gütschow, I Sosič
Frontiers in Chemistry 9, 463, 2021
1282021
Systematic exploration of different E3 ubiquitin ligases: an approach towards potent and selective CDK6 degraders
C Steinebach, YLD Ng, I Sosič, CS Lee, S Chen, S Lindner, LP Vu, ...
Chemical Science 11 (13), 3474-3486, 2020
1012020
PROTAC-mediated crosstalk between E3 ligases
C Steinebach, H Kehm, S Lindner, LP Vu, S Köpff, ÁL Mármol, C Weiler, ...
Chemical Communications 55 (12), 1821-1824, 2019
952019
E3 ligase ligand chemistries: from building blocks to protein degraders
I Sosič, A Bricelj, C Steinebach
Chemical Society Reviews, 2022
662022
A MedChem toolbox for cereblon-directed PROTACs
C Steinebach, I Sosič, S Lindner, A Bricelj, F Kohl, YLD Ng, M Monschke, ...
MedChemComm 10 (6), 1037-1041, 2019
562019
Proteomic profiling reveals CDK6 upregulation as a targetable resistance mechanism for lenalidomide in multiple myeloma
YLD Ng, E Ramberger, SR Bohl, A Dolnik, C Steinebach, T Conrad, ...
Nature Communications 13 (1), 1-13, 2022
382022
Influence of Linker Attachment Points on the Stability and Neosubstrate Degradation of Cereblon Ligands
A Bricelj, YL Dora Ng, D Ferber, R Kuchta, S Müller, M Monschke, ...
ACS Medicinal Chemistry Letters, 2021
362021
Lenalidomide and pomalidomide potently interfere with induction of myeloid‐derived suppressor cells in multiple myeloma
S Kuwahara‐Ota, Y Shimura, C Steinebach, R Isa, J Yamaguchi, ...
British Journal of Haematology 191 (5), 784-795, 2020
312020
Development of the first non-hydroxamate selective HDAC6 degraders
T Keuler, B König, N Bückreiß, F Kraft, P König, L Schäker-Hübner, ...
Chemical Communications, 2022
242022
A Facile Synthesis of Ligands for the von Hippel–Lindau E3 Ligase
C Steinebach, SA Voell, LP Vu, A Bricelj, I Sosič, G Schnakenburg, ...
Synthesis 52 (17), 2521-2527, 2020
242020
Targeting the deubiquitinase USP7 for degradation with PROTACs
A Murgai, I Sosič, M Gobec, P Lemnitzer, M Proj, S Wittenburg, R Voget, ...
Chemical Communications 58 (63), 8858-8861, 2022
232022
Chemical inactivation of the E3 ubiquitin ligase cereblon by pomalidomide-based homo-PROTACs
S Lindner, C Steinebach, H Kehm, M Mangold, M Gütschow, J Krönke
JoVE (Journal of Visualized Experiments), e59472, 2019
222019
Design, synthesis, and characterization of PROTACs targeting the androgen receptor in prostate and lung cancer models
LM Gockel, V Pfeifer, F Baltes, RD Bachmaier, KG Wagner, G Bendas, ...
Archiv der Pharmazie, e202100467, 2022
152022
Antiangiogenic Activity and in Silico Cereblon Binding Analysis of Novel Thalidomide Analogs
ML Peach, SL Beedie, CH Chau, MK Collins, S Markolovic, W Luo, ...
Molecules 25 (23), 5683, 2020
152020
On the correlation of cereblon binding, fluorination and antiangiogenic properties of immunomodulatory drugs
C Heim, S Maiwald, C Steinebach, MK Collins, J Strope, CH Chau, ...
Biochemical and Biophysical Research Communications 534, 67-72, 2020
142020
Solubility and Stability Enhanced Oral Formulations for the Anti-Infective Corallopyronin A
AK Krome, T Becker, S Kehraus, A Schiefer, C Steinebach, T Aden, ...
Pharmaceutics 12 (11), 1105, 2020
132020
Solubility Enhanced Formulation Approaches to Overcome Oral Delivery Obstacles of PROTACs
F Pöstges, K Kayser, J Appelhaus, M Monschke, M Gütschow, ...
Pharmaceutics 15 (1), 156, 2023
122023
Synthesis and antiangiogenic properties of tetrafluorophthalimido and tetrafluorobenzamido barbituric acids
A Ambrożak, C Steinebach, ER Gardner, SL Beedie, G Schnakenburg, ...
ChemMedChem 11 (23), 2621, 2016
122016
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