ClC-7 requires Ostm1 as a β-subunit to support bone resorption and lysosomal function PF Lange, L Wartosch, TJ Jentsch, JC Fuhrmann Nature 440 (7081), 220-223, 2006 | 376 | 2006 |
Active site specificity profiling of the matrix metalloproteinase family: Proteomic identification of 4300 cleavage sites by nine MMPs explored with structural and synthetic … U Eckhard, PF Huesgen, O Schilling, CL Bellac, GS Butler, JH Cox, ... Matrix biology 49, 37-60, 2016 | 218 | 2016 |
Network analyses reveal pervasive functional regulation between proteases in the human protease web N Fortelny, JH Cox, R Kappelhoff, AE Starr, PF Lange, P Pavlidis, ... PLoS biology 12 (5), e1001869, 2014 | 177 | 2014 |
LysargiNase mirrors trypsin for protein C-terminal and methylation-site identification PF Huesgen, PF Lange, LD Rogers, N Solis, U Eckhard, O Kleifeld, ... Nature methods 12 (1), 55-58, 2015 | 156 | 2015 |
Proteome TopFIND 3.0 with TopFINDer and PathFINDer: database and analysis tools for the association of protein termini to pre-and post-translational events N Fortelny, S Yang, P Pavlidis, PF Lange, CM Overall Nucleic acids research 43 (D1), D290-D297, 2015 | 129 | 2015 |
Annotating N termini for the human proteome project: N termini and Nα-acetylation status differentiate stable cleaved protein species from degradation remnants in the human … PF Lange, PF Huesgen, K Nguyen, CM Overall Journal of proteome research 13 (4), 2028-2044, 2014 | 110 | 2014 |
Macrophage matrix metalloproteinase-12 dampens inflammation and neutrophil influx in arthritis CL Bellac, A Dufour, MJ Krisinger, A Loonchanta, AE Starr, ... Cell Reports 9 (2), 618-632, 2014 | 108 | 2014 |
TopFIND, a knowledgebase linking protein termini with function PF Lange, CM Overall Nature methods 8 (9), 703-704, 2011 | 100 | 2011 |
Protein TAILS: when termini tell tales of proteolysis and function PF Lange, CM Overall Current Opinion in Chemical Biology 17 (1), 73-82, 2013 | 97 | 2013 |
Novel matrix metalloproteinase inhibitor [18F] marimastat-aryltrifluoroborate as a probe for in vivo positron emission tomography imaging in cancer U auf dem Keller, CL Bellac, Y Li, Y Lou, PF Lange, R Ting, C Harwig, ... Cancer research 70 (19), 7562-7569, 2010 | 85 | 2010 |
Sensitive determination of proteolytic proteoforms in limited microscale proteome samples SSH Weng, F Demir, EK Ergin, S Dirnberger, A Uzozie, D Tuscher, ... Molecular & Cellular Proteomics 18 (11), 2335-2347, 2019 | 82 | 2019 |
TAILS N-terminomics and proteomics show protein degradation dominates over proteolytic processing by cathepsins in pancreatic tumors A Prudova, V Gocheva, U Auf dem Keller, U Eckhard, OC Olson, L Akkari, ... Cell reports 16 (6), 1762-1773, 2016 | 79 | 2016 |
Proteomic amino-termini profiling reveals targeting information for protein import into complex plastids PF Huesgen, M Alami, PF Lange, LJ Foster, WP Schröder, CM Overall, ... PloS one 8 (9), e74483, 2013 | 58 | 2013 |
TopFIND 2.0—linking protein termini with proteolytic processing and modifications altering protein function PF Lange, PF Huesgen, CM Overall Nucleic acids research 40 (D1), D351-D361, 2012 | 58 | 2012 |
HMMR acts in the PLK1-dependent spindle positioning pathway and supports neural development M Connell, H Chen, J Jiang, CW Kuan, A Fotovati, TLH Chu, Z He, ... Elife 6, e28672, 2017 | 52 | 2017 |
Towards kit-like 18 F-labeling of marimastat, a noncovalent inhibitor drug for in vivo PET imaging cancer associated matrix metalloproteases Y Li, R Ting, CW Harwig, U auf dem Keller, CL Bellac, PF Lange, ... MedChemComm 2 (10), 942-949, 2011 | 49 | 2011 |
Ensembles of protein termini and specific proteolytic signatures as candidate biomarkers of disease PF Huesgen, PF Lange, CM Overall PROTEOMICS–Clinical Applications 8 (5-6), 338-350, 2014 | 32 | 2014 |
Modification of BRCA1-associated breast cancer risk by HMMR overexpression F Mateo, Z He, L Mei, GR de Garibay, C Herranz, N García, A Lorentzian, ... Nature communications 13 (1), 1895, 2022 | 29 | 2022 |
Fold-change compression: an unexplored but correctable quantitative bias caused by nonlinear electrospray ionization responses in untargeted metabolomics H Yu, S Xing, L Nierves, PF Lange, T Huan Analytical chemistry 92 (10), 7011-7019, 2020 | 29 | 2020 |
Active site specificity profiling datasets of matrix metalloproteinases (MMPs) 1, 2, 3, 7, 8, 9, 12, 13 and 14 U Eckhard, PF Huesgen, O Schilling, CL Bellac, GS Butler, JH Cox, ... Data in brief 7, 299-310, 2016 | 27 | 2016 |