Microdroplets in microfluidics: an evolving platform for discoveries in chemistry and biology AB Theberge, F Courtois, Y Schaerli, M Fischlechner, C Abell, F Hollfelder, ... Angewandte Chemie International Edition 49 (34), 5846-5868, 2010 | 1225 | 2010 |
Microdroplets: a sea of applications? A Huebner, S Sharma, M Srisa-Art, F Hollfelder, JB Edel, AJ Demello Lab on a Chip 8 (8), 1244-1254, 2008 | 790 | 2008 |
Static microdroplet arrays: a microfluidic device for droplet trapping, incubation and release for enzymatic and cell-based assays A Huebner, D Bratton, G Whyte, M Yang, AJ Demello, C Abell, F Hollfelder Lab on a Chip 9 (5), 692-698, 2009 | 442 | 2009 |
Quantitative detection of protein expression in single cells using droplet microfluidics A Huebner, M Srisa-Art, D Holt, C Abell, F Hollfelder, AJ Demello, JB Edel Chemical communications, 1218-1220, 2007 | 436 | 2007 |
Ultrahigh-throughput discovery of promiscuous enzymes by picodroplet functional metagenomics PY Colin, B Kintses, F Gielen, CM Miton, G Fischer, MF Mohamed, ... Nature communications 6 (1), 10008, 2015 | 404 | 2015 |
Continuous-flow polymerase chain reaction of single-copy DNA in microfluidic microdroplets Y Schaerli, RC Wootton, T Robinson, V Stein, C Dunsby, MAA Neil, ... Analytical chemistry 81 (1), 302-306, 2009 | 366 | 2009 |
The role of protein dynamics in the evolution of new enzyme function E Campbell, M Kaltenbach, GJ Correy, PD Carr, BT Porebski, ... Nature chemical biology 12 (11), 944-950, 2016 | 290 | 2016 |
Ultrahigh-throughput–directed enzyme evolution by absorbance-activated droplet sorting (AADS) F Gielen, R Hours, S Emond, M Fischlechner, U Schell, F Hollfelder Proceedings of the National Academy of Sciences 113 (47), E7383-E7389, 2016 | 267 | 2016 |
Picoliter cell lysate assays in microfluidic droplet compartments for directed enzyme evolution B Kintses, C Hein, MF Mohamed, M Fischlechner, F Courtois, C Lainé, ... Chemistry & Biology 19 (8), 1001-1009, 2012 | 265 | 2012 |
What makes an enzyme promiscuous? A Babtie, N Tokuriki, F Hollfelder Current opinion in chemical biology 14 (2), 200-207, 2010 | 256 | 2010 |
Ultrarapid generation of femtoliter microfluidic droplets for single-molecule-counting immunoassays J Shim, RT Ranasinghe, CA Smith, SM Ibrahim, F Hollfelder, WTS Huck, ... ACS nano 7 (7), 5955-5964, 2013 | 249 | 2013 |
One in a million: flow cytometric sorting of single cell-lysate assays in monodisperse picolitre double emulsion droplets for directed evolution A Zinchenko, SRA Devenish, B Kintses, PY Colin, M Fischlechner, ... Analytical chemistry 86 (5), 2526-2533, 2014 | 246 | 2014 |
Controlling the retention of small molecules in emulsion microdroplets for use in cell-based assays F Courtois, LF Olguin, G Whyte, AB Theberge, WTS Huck, F Hollfelder, ... Analytical chemistry 81 (8), 3008-3016, 2009 | 243 | 2009 |
Development of quantitative cell-based enzyme assays in microdroplets A Huebner, LF Olguin, D Bratton, G Whyte, WTS Huck, AJ De Mello, ... Analytical chemistry 80 (10), 3890-3896, 2008 | 242 | 2008 |
Cross-talk between histone modifications in response to histone deacetylase inhibitors: MLL4 links histone H3 acetylation and histone H3K4 methylation KP Nightingale, S Gendreizig, DA White, C Bradbury, F Hollfelder, ... Journal of Biological Chemistry 282 (7), 4408-4416, 2007 | 224 | 2007 |
Microfluidic droplets: new integrated workflows for biological experiments B Kintses, LD van Vliet, SRA Devenish, F Hollfelder Current opinion in chemical biology 14 (5), 548-555, 2010 | 219 | 2010 |
An integrated device for monitoring time‐dependent in vitro expression from single genes in picolitre droplets F Courtois, LF Olguin, G Whyte, D Bratton, WTS Huck, C Abell, ... ChemBioChem 9 (3), 439-446, 2008 | 215 | 2008 |
Method of synthesis and testing of combinatorial libraries using microcapsules AD Griffiths, C Abell, F Hollfelder, E Mastrobattista US Patent 10,052,605, 2018 | 210* | 2018 |
Selection by compartmentalised screening AD Griffiths, C Abell, F Hollfelder, E Mastrobattista US Patent 9,448,172, 2016 | 209* | 2016 |
The potential of microfluidic water-in-oil droplets in experimental biology Y Schaerli, F Hollfelder Molecular Biosystems 5 (12), 1392-1404, 2009 | 207 | 2009 |