A potent peptide-steroid conjugate accumulates in cartilage and reverses arthritis without evidence of systemic corticosteroid exposure ML Cook Sangar, EJ Girard, G Hopping, C Yin, F Pakiam, MY Brusniak, ... Science translational medicine 12 (533), eaay1041, 2020 | 39 | 2020 |
Engineering and functionalization of large circular tandem repeat protein nanoparticles CE Correnti, JP Hallinan, LA Doyle, RO Ruff, CA Jaeger-Ruckstuhl, Y Xu, ... Nature structural & molecular biology 27 (4), 342-350, 2020 | 35 | 2020 |
A TfR-binding cystine-dense peptide promotes blood–brain barrier penetration of bioactive molecules ZR Crook, E Girard, GP Sevilla, M Merrill, D Friend, PB Rupert, F Pakiam, ... Journal of molecular biology 432 (14), 3989-4009, 2020 | 30 | 2020 |
Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell activation promotes memory-associated gene regulatory networks CA Jaeger-Ruckstuhl, Y Lo, E Fulton, OG Waltner, TB Shabaneh, S Simon, ... Immunity 57 (2), 287-302. e12, 2024 | 8 | 2024 |
Ex silico engineering of cystine-dense peptides yielding a potent bispecific T cell engager ZR Crook, EJ Girard, GP Sevilla, MY Brusniak, PB Rupert, DJ Friend, ... Science translational medicine 14 (645), eabn0402, 2022 | 5 | 2022 |
Novel mesothelin antibodies enable crystallography of the intact mesothelin ectodomain and engineering of potent, T cell-engaging bispecific therapeutics I Lin, PB Rupert, K Pilat, RO Ruff, DJ Friend, MK Chan, M Clarke, ... Frontiers in Drug Discovery 3, 1216516, 2023 | 3 | 2023 |
Abstract C050: Leveraging ECM deposition by CAF-like Ewing sarcoma tumor cells to target micrometastases with matrix-binding VHHs ED Wrenn, JP Price, RO Ruff, NM Garcia, JM Olson, ER Lawlor Cancer Research 84 (22_Supplement), C050-C050, 2024 | | 2024 |
Advances in cystine-dense peptide (CDP) screening and therapeutic applications ZR Crook, EJ Girard, GP Sevilla, MY Brusniak, PB Rupert, DJ Friend, ... Cancer Research 82 (12_Supplement), 1043-1043, 2022 | | 2022 |
Unique Solutions to a Common Problem: Understanding How I‐CreI Homologs Recognize the Same DNA Target Sequence CR Polkinghorn, B Kaiser, N Wylie, M Tang, R Ruff The FASEB Journal 31, 603.13-603.13, 2017 | | 2017 |
Investigating The DNA Binding Constraints Of The I‐Sob2593 Meganuclease R Ruff, B Kaiser The FASEB Journal 30, 1070.7-1070.7, 2016 | | 2016 |
CD27 Costimulation Modulates Naïve T Cell Activation Through TRAF2/SHP-1 and Induces Memory-Associated Gene Regulatory Networks C Jaeger, Y Lo, E Fulton, O Waltner, TB Shabaneh, CE Correnti, ... | | |