| Opportunities and challenges in phenotypic drug discovery: an industry perspective JG Moffat, F Vincent, JA Lee, J Eder, M Prunotto Nature reviews Drug discovery 16 (8), 531-543, 2017 | 855 | 2017 |
| Identification and characterization of novel TRPV4 modulators F Vincent, A Acevedo, MT Nguyen, M Dourado, J DeFalco, A Gustafson, ... Biochemical and biophysical research communications 389 (3), 490-494, 2009 | 256 | 2009 |
| Developing predictive assays: the phenotypic screening “rule of 3” F Vincent, P Loria, M Pregel, R Stanton, L Kitching, K Nocka, R Doyonnas, ... Science translational medicine 7 (293), 293ps15-293ps15, 2015 | 210 | 2015 |
| TRPV4 agonists and antagonists F Vincent, M AJ Duncton Current topics in medicinal chemistry 11 (17), 2216-2226, 2011 | 180 | 2011 |
| Discovery of a JAK3-selective inhibitor: functional differentiation of JAK3-selective inhibition over pan-JAK or JAK1-selective inhibition JB Telliez, ME Dowty, L Wang, J Jussif, T Lin, L Li, E Moy, P Balbo, W Li, ... ACS chemical biology 11 (12), 3442-3451, 2016 | 153 | 2016 |
| Phenotypic drug discovery: recent successes, lessons learned and new directions F Vincent, A Nueda, J Lee, M Schenone, M Prunotto, M Mercola Nature Reviews Drug Discovery 21 (12), 899-914, 2022 | 147 | 2022 |
| Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF … A Thorarensen, ME Dowty, ME Banker, B Juba, J Jussif, T Lin, F Vincent, ... Journal of medicinal chemistry 60 (5), 1971-1993, 2017 | 138 | 2017 |
| Deregulated Cdk5 promotes oxidative stress and mitochondrial dysfunction KH Sun, Y De Pablo, F Vincent, K Shah Journal of neurochemistry 107 (1), 265-278, 2008 | 135 | 2008 |
| Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of ((S)-2,2-Difluorocyclopropyl)((1R,5S)-3-(2-((1-methyl-1H-pyrazol-4-yl … A Fensome, CM Ambler, E Arnold, ME Banker, MF Brown, J Chrencik, ... Journal of medicinal chemistry 61 (19), 8597-8612, 2018 | 132 | 2018 |
| Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent … KL Lee, CM Ambler, DR Anderson, BP Boscoe, AG Bree, JI Brodfuehrer, ... Journal of medicinal chemistry 60 (13), 5521-5542, 2017 | 131 | 2017 |
| Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay J Hall, A Brault, F Vincent, S Weng, H Wang, D Dumlao, A Aulabaugh, ... PLoS One 12 (9), e0184843, 2017 | 130 | 2017 |
| Novel genetic tools reveal Cdk5's major role in Golgi fragmentation in Alzheimer's disease KH Sun, Y de Pablo, F Vincent, EO Johnson, AK Chavers, K Shah Molecular biology of the cell 19 (7), 3052-3069, 2008 | 103 | 2008 |
| Deregulated Cdk5 triggers aberrant activation of cell cycle kinases and phosphatases inducing neuronal death KH Chang, F Vincent, K Shah Journal of cell science 125 (21), 5124-5137, 2012 | 94 | 2012 |
| Nuclear envelope dispersion triggered by deregulated Cdk5 precedes neuronal death KH Chang, PS Multani, KH Sun, F Vincent, Y De Pablo, S Ghosh, R Gupta, ... Molecular biology of the cell 22 (9), 1452-1462, 2011 | 84 | 2011 |
| The catalytic mechanism of cyclic GMP‐AMP synthase (cGAS) and implications for innate immunity and inhibition J Hall, EC Ralph, S Shanker, H Wang, LJ Byrnes, R Horst, J Wong, ... Protein Science 26 (12), 2367-2380, 2017 | 61 | 2017 |
| ATP-mediated kinome selectivity: the missing link in understanding the contribution of individual JAK kinase isoforms to cellular signaling A Thorarensen, ME Banker, A Fensome, JB Telliez, B Juba, F Vincent, ... ACS chemical biology 9 (7), 1552-1558, 2014 | 56 | 2014 |
| Small molecule screening in human induced pluripotent stem cell-derived terminal cell types SJ Engle, F Vincent Journal of Biological Chemistry 289 (8), 4562-4570, 2014 | 55 | 2014 |
| Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists S Liu, LA Dakin, L Xing, JM Withka, PV Sahasrabudhe, W Li, ME Banker, ... Scientific Reports 6 (1), 30859, 2016 | 52 | 2016 |
| Hit triage and validation in phenotypic screening: considerations and strategies F Vincent, PM Loria, AD Weston, CM Steppan, R Doyonnas, YM Wang, ... Cell Chemical Biology 27 (11), 1332-1346, 2020 | 43 | 2020 |
| Divergent roles of c-Src in controlling platelet-derived growth factor-dependent signaling in fibroblasts K Shah, F Vincent Molecular biology of the cell 16 (11), 5418-5432, 2005 | 42 | 2005 |
