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Mengyang Chang
Mengyang Chang
在 arizona.edu 的电子邮件经过验证
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Bioorthogonal PROTAC prodrugs enabled by on-target activation
M Chang, F Gao, D Pontigon, G Gnawali, H Xu, W Wang
Journal of the American Chemical Society 145 (25), 14155-14163, 2023
512023
Metabonomics reveals that triclocarban affects liver metabolism by affecting glucose metabolism, β-oxidation of fatty acids, and the TCA cycle in male mice
W Li, W Zhang, M Chang, J Ren, W Xie, H Chen, Z Zhang, X Zhuang, ...
Toxicology Letters 299, 76-85, 2018
392018
Building bioorthogonal click-release capable artificial receptors on cancer cell surface for imaging, drug targeting and delivery
J Chen, P Ji, G Gnawali, M Chang, F Gao, H Xu, W Wang
Acta Pharmaceutica Sinica B 13 (6), 2736-2746, 2023
162023
MDM2-BCL-XL PROTACs enable degradation of BCL-XL and stabilization of p53
M Chang, F Gao, J Chen, G Gnawali, W Wang
Acta materia medica 1 (3), 333, 2022
132022
Senolysis Enabled by Senescent Cell‐Sensitive Bioorthogonal Tetrazine Ligation
M Chang, Y Dong, H Xu, AB Cruickshank‐Taylor, JS Kozora, B Behpour, ...
Angewandte Chemie International Edition 63 (9), e202315425, 2024
112024
Quadrupole orbitrap mass spectrometer-based metabonomic elucidation of influences of short-term di (2-ethylhexyl) phthalate exposure on cardiac metabolism in male mice
W Li, W Zhang, M Chang, J Ren, X Zhuang, Z Zhang, Y Cui, H Chen, B Xu, ...
Chemical Research in Toxicology 31 (11), 1185-1194, 2018
82018
Photoredox Catalytic Installation of an Alkyl/Aryl Side Chain and Deuterium into (S)-Methyleneoxazolidinone: Synthesis of Enantioenriched α-Deuterated α-Amino …
Y Dong, X Meng, G Gnawali, M Chang, W Wang
Organic Letters 25 (25), 4745-4749, 2023
72023
Selective Elimination of Senescent Cancer Cells by Galacto-Modified PROTACs
M Chang, F Gao, G Gnawali, H Xu, Y Dong, X Meng, W Li, Z Wang, ...
Journal of Medicinal Chemistry 67 (9), 7301-7311, 2024
62024
Inhibition of autophagy antagonizes breast cancer brain metastogenesis and augments the anticancer activity of lapatinib
ST Nawrocki, CM Espitia, MJC Espinoza, TM Jones, ME Gamble, ...
Clinical and Translational Medicine 14 (4), 2024
22024
Senolytic Prodrugs: A Promising Approach to Enhancing Senescence‐Targeting Intervention
M Chang, Y Dong, AB Cruickshank‐Taylor, G Gnawali, F Bi, W Wang
Chembiochem 25 (22), e202400355, 2024
12024
Control of tetrazine bioorthogonal reactivity by naphthotube and phenyltetrazine host-guest pairs
K Lou, W Xing, X Meng, M Chang, W Wang
Chem 9 (10), 2727-2730, 2023
12023
Dual-Performing Vinyltetrazine for Rapid, Selective Bioconjugation and Functionalization of Cysteine Proteins
M Chang, H Xu, Y Dong, G Gnawali, F Bi, W Wang
ACS chemical biology, 2024
2024
Targeting autophagy: A promising approach for the treatment of breast cancer brain metastases
ST Nawrocki, CM Espitia, MJC Espinoza, ME Gamble, S Sureshkumar, ...
Clinical and Translational Discovery 4 (4), e340, 2024
2024
Site-Selective Modification of Secondary Amine Moieties on Native Peptides, Proteins, and Natural Products with Ynones
F Gao, M Chang, X Meng, H Xu, G Gnawali, Y Dong, B Lopez, W Wang
Bioconjugate Chemistry 34 (9), 1553-1562, 2023
2023
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