| A physiologically based pharmacokinetic model of isoniazid and its application in individualizing tuberculosis chemotherapy H Cordes, C Thiel, HE Aschmann, V Baier, LM Blank, L Kuepfer Antimicrobial agents and chemotherapy 60 (10), 6134-6145, 2016 | 56 | 2016 |
| Bringing in vitro analysis closer to in vivo: Studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling M Verheijen, Y Schrooders, H Gmuender, R Nudischer, O Clayton, ... Toxicology letters 294, 184-192, 2018 | 36 | 2018 |
| A model-based assay design to reproduce in vivo patterns of acute drug-induced toxicity L Kuepfer, O Clayton, C Thiel, H Cordes, R Nudischer, LM Blank, V Baier, ... Archives of toxicology 92, 553-555, 2018 | 36 | 2018 |
| Network integration and modelling of dynamic drug responses at multi-omics levels N Selevsek, F Caiment, R Nudischer, H Gmuender, I Agarkova, ... Communications biology 3 (1), 573, 2020 | 35 | 2020 |
| Integration of genome-scale metabolic networks into whole-body PBPK models shows phenotype-specific cases of drug-induced metabolic perturbation H Cordes, C Thiel, V Baier, LM Blank, L Kuepfer NPJ systems biology and applications 4 (1), 10, 2018 | 34 | 2018 |
| A 3D heterotypic multicellular tumor spheroid assay platform to discriminate drug effects on stroma versus cancer cells Z Weydert, M Lal-Nag, L Mathews-Greiner, C Thiel, H Cordes, L Küpfer, ... SLAS DISCOVERY: Advancing the Science of Drug Discovery 25 (3), 265-276, 2020 | 24 | 2020 |
| Model-based contextualization of in vitro toxicity data quantitatively predicts in vivo drug response in patients C Thiel, H Cordes, I Conde, JV Castell, LM Blank, L Kuepfer Archives of toxicology 91, 865-883, 2017 | 24 | 2017 |
| A comparative analysis of drug-induced hepatotoxicity in clinically relevant situations C Thiel, H Cordes, L Fabbri, HE Aschmann, V Baier, I Smit, F Atkinson, ... PLoS computational biology 13 (2), e1005280, 2017 | 19 | 2017 |
| Using quantitative systems pharmacology to evaluate the drug efficacy of COX-2 and 5-LOX inhibitors in therapeutic situations C Thiel, I Smit, V Baier, H Cordes, B Fabry, LM Blank, L Kuepfer NPJ systems biology and applications 4 (1), 28, 2018 | 18 | 2018 |
| A physiology-based model of human bile acid metabolism for predicting bile acid tissue levels after drug administration in healthy subjects and BRIC type 2 patients V Baier, H Cordes, C Thiel, JV Castell, UP Neumann, LM Blank, L Kuepfer Frontiers in physiology 10, 1192, 2019 | 16 | 2019 |
| Multiscale modeling reveals inhibitory and stimulatory effects of caffeine on acetaminophen‐induced toxicity in humans C Thiel, H Cordes, V Baier, LM Blank, L Kuepfer CPT: pharmacometrics & systems pharmacology 6 (2), 136-146, 2017 | 11 | 2017 |
| A model‐based workflow to benchmark the clinical cholestasis risk of drugs V Baier, O Clayton, R Nudischer, H Cordes, ARP Schneider, C Thiel, ... Clinical Pharmacology & Therapeutics 110 (5), 1293-1301, 2021 | 6 | 2021 |
| Gene expression databases for physiologically based pharmacokinetic modeling of humans and animal species H Cordes, H Rapp CPT: Pharmacometrics & Systems Pharmacology 12 (3), 311-319, 2023 | 5 | 2023 |
| A physiology-based model of bile acid metabolism shows altered tissue concentrations after drug administration and in specific genotype subgroups V Baier, H Cordes, C Thiel, U Neumann, LM Blank, L Kuepfer bioRxiv, 450965, 2018 | 3 | 2018 |
| Multi-scale modeling in human systems pharmacology & physiology H Cordes, J Sáez Rodríguez, LM Blank Fachgruppe Biologie, 2019 | 1 | 2019 |
| Modellierung metabolischer Netzwerke im menschlichen Körper: Systembiologie H Cordes, C Thiel, LM Blank, L Küpfer BIOspektrum 20, 39-41, 2014 | 1 | 2014 |
| MULTI-SCALE PHYSIOLOGICALLY-BASED QUANTITATIVE SYSTEMS PHARMACOLOGY MODELING FOR SIMULATING CELLULAR DRUG RESPONSES WITHIN A WHOLE-BODY CONTEXT. V Baier, C Thiel, H Cordes, L Blank, L Kuepfer CLINICAL PHARMACOLOGY & THERAPEUTICS 105, S30-S30, 2019 | | 2019 |
| Edaravone medication is known to be an antioxidant, and oxidative stress has been hypothesized to be part of the process that kills neurons in people with ALS Menu V Baier, O Clayton, R Nudischer, H Cordes, ARP Schneider, C Thiel, ... | | |
| A PBPK Model of Isoniazid and its Application in Individualizing Tuberculosis Chemotherapy H Cordes, C Thiel, HM Aschmann, V Baier, L Blank, L Kuepfer | | |
Professor Lars KuepferInstitute for systems medicine with focus on organ interaction, RWTH Aachen在 rwth-aachen.de 的电子邮件经过验证
