| Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development A Cavazzuti, G Paglietti, WN Hunter, F Gamarro, S Piras, M Loriga, ... Proceedings of the National Academy of Sciences 105 (5), 1448-1453, 2008 | 167 | 2008 |
| One scaffold, three binding modes: novel and selective pteridine reductase 1 inhibitors derived from fragment hits discovered by virtual screening CP Mpamhanga, D Spinks, LB Tulloch, EJ Shanks, DA Robinson, ... Journal of medicinal chemistry 52 (14), 4454-4465, 2009 | 113 | 2009 |
| Structure-based design of pteridine reductase inhibitors targeting African sleeping sickness and the leishmaniases LB Tulloch, VP Martini, J Iulek, JK Huggan, JH Lee, CL Gibson, TK Smith, ... Journal of medicinal chemistry 53 (1), 221-229, 2010 | 95 | 2010 |
| The inhibitory effect of phospholemman on the sodium pump requires its palmitoylation LB Tulloch, J Howie, KJ Wypijewski, CR Wilson, WG Bernard, ... Journal of Biological Chemistry 286 (41), 36020-36031, 2011 | 91 | 2011 |
| Regulation of the cardiac sodium pump W Fuller, LB Tulloch, MJ Shattock, SC Calaghan, J Howie, KJ Wypijewski Cellular and Molecular Life Sciences 70, 1357-1380, 2013 | 86 | 2013 |
| Design, synthesis and trypanocidal activity of lead compounds based on inhibitors of parasite glycolysis MW Nowicki, LB Tulloch, L Worralll, IW McNae, V Hannaert, PAM Michels, ... Bioorganic & medicinal chemistry 16 (9), 5050-5061, 2008 | 85 | 2008 |
| Structure and reactivity of Trypanosoma brucei pteridine reductase: inhibition by the archetypal antifolate methotrexate A Dawson, F Gibellini, N Sienkiewicz, LB Tulloch, PK Fyfe, K McLuskey, ... Molecular microbiology 61 (6), 1457-1468, 2006 | 67 | 2006 |
| Diversity oriented syntheses of fused pyrimidines designed as potential antifolates CL Gibson, JK Huggan, A Kennedy, L Kiefer, JH Lee, CJ Suckling, ... Organic & biomolecular chemistry 7 (9), 1829-1842, 2009 | 61 | 2009 |
| The trypanosome alternative oxidase: a potential drug target? SK Menzies, LB Tulloch, GJ Florence, TK Smith Parasitology 145 (2), 175-183, 2018 | 47 | 2018 |
| Direct and indirect approaches to identify drug modes of action LB Tulloch, SK Menzies, RP Coron, MD Roberts, GJ Florence, TK Smith Iubmb Life 70 (1), 9-22, 2018 | 40 | 2018 |
| A separate pool of cardiac phospholemman that does not regulate or associate with the sodium pump: multimers of phospholemman in ventricular muscle KJ Wypijewski, J Howie, L Reilly, LB Tulloch, KL Aughton, LM McLatchie, ... Journal of Biological Chemistry 288 (19), 13808-13820, 2013 | 37 | 2013 |
| Structure of recombinant Leishmania donovani pteridine reductase reveals a disordered active site KL Barrack, LB Tulloch, LA Burke, PK Fyfe, WN Hunter Structural Biology and Crystallization Communications 67 (1), 33-37, 2011 | 32 | 2011 |
| Photo-affinity labelling and biochemical analyses identify the target of trypanocidal simplified natural product analogues LB Tulloch, SK Menzies, AL Fraser, ER Gould, EF King, MK Zacharova, ... PLoS Neglected Tropical Diseases 11 (9), e0005886, 2017 | 31 | 2017 |
| Sulphate removal induces a major conformational change in Leishmania mexicana pyruvate kinase in the crystalline state LB Tulloch, HP Morgan, V Hannaert, PAM Michels, LA Fothergill-Gilmore, ... Journal of molecular biology 383 (3), 615-626, 2008 | 30 | 2008 |
| Structure of Staphylococcus aureus 1, 4-dihydroxy-2-naphthoyl-CoA synthase (MenB) in complex with acetoacetyl-CoA V Ulaganathan, MF Agacan, L Buetow, LB Tulloch, WN Hunter Acta Crystallographica Section F: Structural Biology and Crystallization …, 2007 | 29 | 2007 |
| High-resolution structures of Trypanosoma brucei pteridine reductase ligand complexes inform on the placement of new molecular entities in the active site of a potential drug … A Dawson, LB Tulloch, KL Barrack, WN Hunter Acta Crystallographica Section D: Biological Crystallography 66 (12), 1334-1340, 2010 | 28 | 2010 |
| Regulation of the cardiac Na+ pump by palmitoylation of its catalytic and regulatory subunits J Howie, LB Tulloch, MJ Shattock, W Fuller Biochemical Society Transactions 41 (1), 95-100, 2013 | 27 | 2013 |
| Non‐natural Acetogenin Analogues as Potent Trypanosoma brucei Inhibitors GJ Florence, AL Fraser, ER Gould, EFB King, SK Menzies, JC Morris, ... ChemMedChem 9 (11), 2548-2556, 2014 | 17 | 2014 |
| Identification of a proteasome-targeting arylsulfonamide with potential for the treatment of Chagas’ disease ML Lima, LB Tulloch, V Corpas-Lopez, S Carvalho, RJ Wall, R Milne, ... Antimicrobial agents and chemotherapy 66 (1), e01535-21, 2022 | 15 | 2022 |
| Greasing the wheels or a spanner in the works? Regulation of the cardiac sodium pump by palmitoylation J Howie, KJ Wypijewski, F Plain, LB Tulloch, NJ Fraser, W Fuller Critical reviews in biochemistry and molecular biology 53 (2), 175-191, 2018 | 15 | 2018 |
