Homozygous mutation of PLCZ1 leads to defective human oocyte activation and infertility that is not rescued by the WW-binding protein PAWP J Escoffier, HC Lee, S Yassine, R Zouari, G Martinez, T Karaouzène, ... Human molecular genetics 25 (5), 878-891, 2016 | 160 | 2016 |
A systematic method for identifying small-molecule modulators of protein–protein interactions AR Horswill, SN Savinov, SJ Benkovic Proceedings of the National Academy of Sciences 101 (44), 15591-15596, 2004 | 158 | 2004 |
Chemoselective Nitration of Phenols with tert-Butyl Nitrite in Solution and on Solid Support D Koley, OC Colón, SN Savinov Organic letters 11 (18), 4172-4175, 2009 | 134 | 2009 |
Homozygous missense mutation L673P in adenylate kinase 7 (AK7) leads to primary male infertility and multiple morphological anomalies of the flagella but not to primary ciliary … P Lorès, C Coutton, E El Khouri, L Stouvenel, M Givelet, L Thomas, ... Human Molecular Genetics 27 (7), 1196-1211, 2018 | 111 | 2018 |
The Cdk/cDc14 module controls activation of the Yen1 holliday junction resolvase to promote genome stability CL Eissler, G Mazón, BL Powers, SN Savinov, LS Symington, MC Hall Molecular cell 54 (1), 80-93, 2014 | 110 | 2014 |
Structure− activity relationships in the binding of chemically derivatized CD4 to gp120 from human immunodeficiency virus H Xie, D Ng, SN Savinov, B Dey, PD Kwong, R Wyatt, AB Smith, ... Journal of medicinal chemistry 50 (20), 4898-4908, 2007 | 73 | 2007 |
The genome of opportunistic fungal pathogen Fusarium oxysporum carries a unique set of lineage-specific chromosomes Y Zhang, H Yang, D Turra, S Zhou, DH Ayhan, GA DeIulio, L Guo, K Broz, ... Communications biology 3 (1), 50, 2020 | 72 | 2020 |
A chemoselective rhodium (II) mediated solid phase 1, 3-dipolar cycloaddition and its application to a thermally self-cleaving furan scaffold DL Whitehouse, KH Nelson Jr, SN Savinov, DJ Austin Tetrahedron letters 38 (41), 7139-7142, 1997 | 69 | 1997 |
Peptide− small molecule hybrids via orthogonal deprotection− chemoselective conjugation to cysteine-anchored scaffolds. A model study AB Smith, SN Savinov, UV Manjappara, IM Chaiken Organic letters 4 (23), 4041-4044, 2002 | 57 | 2002 |
Mutations in TTC29, encoding an evolutionarily conserved axonemal protein, result in asthenozoospermia and male infertility P Lorès, D Dacheux, ZE Kherraf, JFN Mbango, C Coutton, L Stouvenel, ... The American Journal of Human Genetics 105 (6), 1148-1167, 2019 | 51 | 2019 |
An improved synthesis and selective coupling of a hydroxy based photolabile linker for solid phase organic synthesis DL Whitehouse, SN Savinov, DJ Austin Tetrahedron letters 38 (45), 7851-7852, 1997 | 49 | 1997 |
X-ray structural and functional studies of the three tandemly linked domains of non-structural protein 3 (nsp3) from murine hepatitis virus reveal conserved functions Y Chen, SN Savinov, AM Mielech, T Cao, SC Baker, AD Mesecar Journal of Biological Chemistry 290 (42), 25293-25306, 2015 | 48 | 2015 |
Interaction of cholesterol with perfringolysin O: what have we learned from functional analysis? SN Savinov, AP Heuck Toxins 9 (12), 381, 2017 | 44 | 2017 |
A metathetical cycloaddition–cycloreversion approach to the formation of furan scaffold libraries DL Whitehouse, KH Nelson, RS Löwe, DJ Austin Bioorganic & medicinal chemistry 6 (8), 1273-1282, 1998 | 42 | 1998 |
Drug screening for discovery of broad-spectrum agents for soil-transmitted nematodes MA Elfawal, SN Savinov, RV Aroian Scientific reports 9 (1), 12347, 2019 | 41 | 2019 |
Chemical and biological mechanisms of phytochemical activation of Nrf2 and importance in disease prevention AL Eggler, SN Savinov 50 Years of Phytochemistry Research: Volume 43, 121-155, 2013 | 41 | 2013 |
Modular evolution of a chiral auxiliary for the 1, 3-dipolar cycloaddition of isomünchnones with vinyl ethers SN Savinov, DJ Austin Organic Letters 4 (9), 1415-1418, 2002 | 39 | 2002 |
Engineering an affinity tag for genetically encoded cyclic peptides TA Naumann, SN Savinov, SJ Benkovic Biotechnology and bioengineering 92 (7), 820-830, 2005 | 33 | 2005 |
Intracellular detection and evolution of site-specific proteases using a genetic selection system KD Verhoeven, OC Altstadt, SN Savinov Applied biochemistry and biotechnology 166, 1340-1354, 2012 | 32 | 2012 |
Diastereofacial solid phase synthesis and self-promoted cleavage of a [2.2. 1] bicyclic diversity scaffold SN Savinov, DJ Austin Organic Letters 4 (9), 1419-1422, 2002 | 32 | 2002 |