Synthesis, in vitro antiproliferative activity, and DNA-binding properties of hybrid molecules containing pyrrolo [2, 1-c][1, 4] benzodiazepine and minor-groove-binding … PG Baraldi, G Balboni, B Cacciari, A Guiotto, S Manfredini, R Romagnoli, ... Journal of medicinal chemistry 42 (25), 5131-5141, 1999 | 171 | 1999 |
δ Opioidmimetic Antagonists: Prototypes for Designing a New Generation of Ultraselective Opioid Peptides S Salvadori, M Attila, G Balboni, C Bianchi, SD Bryant, O Crescenzi, ... Molecular medicine 1, 678-689, 1995 | 155 | 1995 |
Peptidic delta opioid receptor agonists produce antidepressant-like effects in the forced swim test and regulate BDNF mRNA expression in rats MM Torregrossa, EM Jutkiewicz, HI Mosberg, G Balboni, SJ Watson, ... Brain research 1069 (1), 172-181, 2006 | 125 | 2006 |
Evaluation of the Dmt− tic pharmacophore: conversion of a potent δ-opioid receptor antagonist into a potent δ agonist and ligands with mixed properties G Balboni, R Guerrini, S Salvadori, C Bianchi, D Rizzi, SD Bryant, ... Journal of medicinal chemistry 45 (3), 713-720, 2002 | 122 | 2002 |
The chemokine Bv8/prokineticin 2 is up-regulated in inflammatory granulocytes and modulates inflammatory pain E Giannini, R Lattanzi, A Nicotra, AF Campese, P Grazioli, I Screpanti, ... Proceedings of the National Academy of Sciences 106 (34), 14646-14651, 2009 | 110 | 2009 |
δ‐, but not µ‐, opioid receptor stabilizes K+ homeostasis by reducing Ca2+ influx in the cortex during acute hypoxia D Chao, A Bazzy‐Asaad, G Balboni, Y Xia Journal of cellular physiology 212 (1), 60-67, 2007 | 110 | 2007 |
Design, synthesis, DNA binding, and biological evaluation of water-soluble hybrid molecules containing two pyrazole analogues of the alkylating cyclopropylpyrroloindole (CPI … PG Baraldi, G Balboni, MG Pavani, G Spalluto, MA Tabrizi, ED Clercq, ... Journal of medicinal chemistry 44 (16), 2536-2543, 2001 | 109 | 2001 |
Evolution of the Dmt-Tic pharmacophore: N-terminal methylated derivatives with extraordinary δ opioid antagonist activity S Salvadori, G Balboni, R Guerrini, R Tomatis, C Bianchi, SD Bryant, ... Journal of medicinal chemistry 40 (19), 3100-3108, 1997 | 108 | 1997 |
Anxiolytic-and antidepressant-like activities of H-Dmt-Tic-NH-CH (CH2-COOH)-Bid (UFP-512), a novel selective delta opioid receptor agonist R Vergura, G Balboni, B Spagnolo, E Gavioli, DG Lambert, J McDonald, ... Peptides 29 (1), 93-103, 2008 | 107 | 2008 |
Indole derivatives as multifunctional drugs: Synthesis and evaluation of antioxidant, photoprotective and antiproliferative activity of indole hydrazones M Demurtas, A Baldisserotto, I Lampronti, D Moi, G Balboni, S Pacifico, ... Bioorganic chemistry 85, 568-576, 2019 | 103 | 2019 |
Potent δ-Opioid Receptor Agonists Containing the Dmt− Tic Pharmacophore G Balboni, S Salvadori, R Guerrini, L Negri, E Giannini, Y Jinsmaa, ... Journal of medicinal chemistry 45 (25), 5556-5563, 2002 | 102 | 2002 |
Further studies on the Dmt-Tic pharmacophore: hydrophobic substituents at the C-terminus endow δ antagonists to manifest μ agonism or μ antagonism S Salvadori, R Guerrini, G Balboni, C Bianchi, SD Bryant, PS Cooper, ... Journal of medicinal chemistry 42 (24), 5010-5019, 1999 | 80 | 1999 |
Triazine compounds as antagonists at Bv8-prokineticin receptors G Balboni, I Lazzari, C Trapella, L Negri, R Lattanzi, E Giannini, A Nicotra, ... Journal of medicinal chemistry 51 (23), 7635-7639, 2008 | 75 | 2008 |
Agonists at the δ‐opioid receptor modify the binding of µ‐receptor agonists to the µ–δ receptor hetero‐oligomer N Kabli, N Martin, T Fan, T Nguyen, A Hasbi, G Balboni, BF O'Dowd, ... British journal of pharmacology 161 (5), 1122-1136, 2010 | 68 | 2010 |
Synthesis and pharmacological activity of deltorphin and dermorphin-related glycopeptides R Tomatis, M Marastoni, G Balboni, R Guerrini, A Capasso, L Sorrentino, ... Journal of medicinal chemistry 40 (18), 2948-2952, 1997 | 67 | 1997 |
Activation of DOR Attenuates Anoxic K+ Derangement via Inhibition of Na+ Entry in Mouse Cortex D Chao, A Bazzy-Asaad, G Balboni, S Salvadori, Y Xia Cerebral Cortex 18 (9), 2217-2227, 2008 | 66 | 2008 |
Conformational dynamics of Kir3. 1/Kir3. 2 channel activation via δ-opioid receptors M Richard-Lalonde, K Nagi, N Audet, R Sleno, M Amraei, M Hogue, ... Molecular pharmacology 83 (2), 416-428, 2013 | 58 | 2013 |
Controlling the activation of the B v8/prokineticin system reduces neuroinflammation and abolishes thermal and tactile hyperalgesia in neuropathic animals D Maftei, V Marconi, F Florenzano, LA Giancotti, M Castelli, S Moretti, ... British journal of pharmacology 171 (21), 4850-4865, 2014 | 57 | 2014 |
Design of δ-opioid peptide antagonists for emerging drug applications LH Lazarus, SD Bryant, PS Cooper, R Guerrini, G Balboni, S Salvadori Drug Discovery Today 3 (6), 284-294, 1998 | 57 | 1998 |
Benzofuran hydrazones as potential scaffold in the development of multifunctional drugs: Synthesis and evaluation of antioxidant, photoprotective and antiproliferative activity A Baldisserotto, M Demurtas, I Lampronti, D Moi, G Balboni, S Vertuani, ... European journal of medicinal chemistry 156, 118-125, 2018 | 55 | 2018 |