The inducible caspase-9 suicide gene system as a “safety switch” to limit on-target, off-tumor toxicities of chimeric antigen receptor T cells T Gargett, MP Brown Frontiers in pharmacology 5, 235, 2014 | 433 | 2014 |
GD2-specific CAR T cells undergo potent activation and deletion following antigen encounter but can be protected from activation-induced cell death by PD-1 blockade T Gargett, W Yu, G Dotti, ES Yvon, SN Christo, JD Hayball, ID Lewis, ... Molecular Therapy 24 (6), 1135-1149, 2016 | 363 | 2016 |
Genome-wide identification of human FOXP3 target genes in natural regulatory T cells TJ Sadlon, BG Wilkinson, S Pederson, CY Brown, S Bresatz, T Gargett, ... The Journal of Immunology 185 (2), 1071-1081, 2010 | 163 | 2010 |
Different cytokine and stimulation conditions influence the expansion and immune phenotype of third-generation chimeric antigen receptor T cells specific for tumor antigen GD2 T Gargett, MP Brown Cytotherapy 17 (4), 487-495, 2015 | 135 | 2015 |
Phase I trial of Lipovaxin-MM, a novel dendritic cell-targeted liposomal vaccine for malignant melanoma T Gargett, MN Abbas, P Rolan, JD Price, KM Gosling, A Ferrante, ... Cancer Immunology, Immunotherapy 67, 1461-1472, 2018 | 79 | 2018 |
GM‐CSF signalling blockade and chemotherapeutic agents act in concert to inhibit the function of myeloid‐derived suppressor cells in vitro T Gargett, SN Christo, TR Hercus, N Abbas, N Singhal, AF Lopez, ... Clinical & translational immunology 5 (12), e119, 2016 | 49 | 2016 |
The role of cytokines and chemokines in shaping the immune microenvironment of glioblastoma: implications for immunotherapy ECF Yeo, MP Brown, T Gargett, LM Ebert Cells 10 (3), 607, 2021 | 46 | 2021 |
Development of CD4+CD25+FoxP3+ regulatory T cells from cord blood hematopoietic progenitor cells JF Hutton, T Gargett, TJ Sadlon, S Bresatz, CY Brown, H Zola, ... Journal of Leucocyte Biology 85 (3), 445-451, 2009 | 46 | 2009 |
GD2-targeting CAR-T cells enhanced by transgenic IL-15 expression are an effective and clinically feasible therapy for glioblastoma T Gargett, LM Ebert, NTH Truong, PM Kollis, K Sedivakova, W Yu, ... Journal for Immunotherapy of Cancer 10 (9), 2022 | 43 | 2022 |
Endothelial, pericyte and tumor cell expression in glioblastoma identifies fibroblast activation protein (FAP) as an excellent target for immunotherapy LM Ebert, W Yu, T Gargett, J Toubia, PM Kollis, MN Tea, BW Ebert, ... Clinical & Translational Immunology 9 (10), e1191, 2020 | 42 | 2020 |
Clinical chimeric antigen receptor‐T cell therapy: a new and promising treatment modality for glioblastoma MP Brown, LM Ebert, T Gargett Clinical & Translational Immunology 8 (5), e1050, 2019 | 41 | 2019 |
BRAF and MEK inhibition variably affect GD2-specific chimeric antigen receptor (CAR) T-cell function in vitro T Gargett, CK Fraser, G Dotti, ES Yvon, MP Brown Journal of immunotherapy 38 (1), 12-23, 2015 | 40 | 2015 |
Optimization of manufacturing conditions for chimeric antigen receptor T cells to favor cells with a central memory phenotype T Gargett, NGA Truong, LM Ebert, W Yu, MP Brown Cytotherapy 21 (6), 593-602, 2019 | 36 | 2019 |
Robust, reversible gene knockdown using a single lentiviral short hairpin RNA vector CY Brown, T Sadlon, T Gargett, E Melville, R Zhang, Y Drabsch, M Ling, ... Human gene therapy 21 (8), 1005-1017, 2010 | 36 | 2010 |
Logic-gated approaches to extend the utility of chimeric antigen receptor T-cell technology LM Ebert, W Yu, T Gargett, MP Brown Biochemical society transactions 46 (2), 391-401, 2018 | 34 | 2018 |
Increase in DNA vaccine efficacy by virosome delivery and co‐expression of a cytolytic protein T Gargett, B Grubor‐Bauk, D Miller, T Garrod, S Yu, S Wesselingh, ... Clinical & translational immunology 3 (6), e18, 2014 | 30 | 2014 |
Induction of antigen‐positive cell death by the expression of Perforin, but not DTa, from a DNA vaccine enhances the immune response T Gargett, B Grubor‐Bauk, TJ Garrod, W Yu, D Miller, L Major, ... Immunology and cell biology 92 (4), 359-367, 2014 | 30 | 2014 |
DNA vaccines encoding membrane‐bound or secreted forms of heat shock protein 70 exhibit improved potency TJ Garrod, B Grubor‐Bauk, T Gargett, Y Li, DS Miller, W Yu, L Major, ... European Journal of Immunology 44 (7), 1992-2002, 2014 | 24 | 2014 |
Effects of chemotherapy agents on circulating leukocyte populations: Potential implications for the success of CAR-T cell therapies NTH Truong, T Gargett, MP Brown, LM Ebert Cancers 13 (9), 2225, 2021 | 23 | 2021 |
A novel challenge model to evaluate the efficacy of hepatitis C virus vaccines in mice W Yu, B Grubor-Bauk, T Gargett, T Garrod, EJ Gowans Vaccine 32 (27), 3409-3416, 2014 | 21 | 2014 |