M2-like macrophages are responsible for collagen degradation through a mannose receptor–mediated pathway DH Madsen, D Leonard, A Masedunskas, A Moyer, HJ Jürgensen, ... Journal of Cell Biology 202 (6), 951-966, 2013 | 340 | 2013 |
Therapeutic targeting of PP2A CM O’Connor, A Perl, D Leonard, J Sangodkar, G Narla The international journal of biochemistry & cell biology 96, 182-193, 2018 | 185 | 2018 |
Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth J Sangodkar, A Perl, R Tohme, J Kiselar, DB Kastrinsky, N Zaware, ... The Journal of clinical investigation 127 (6), 2081-2090, 2017 | 184 | 2017 |
Selective PP2A enhancement through biased heterotrimer stabilization D Leonard, W Huang, S Izadmehr, CM O’Connor, DD Wiredja, Z Wang, ... Cell 181 (3), 688-701. e16, 2020 | 132 | 2020 |
The highly recurrent PP2A Aα-subunit mutation P179R alters protein structure and impairs PP2A enzyme function to promote endometrial tumorigenesis SE Taylor, CM O'Connor, Z Wang, G Shen, H Song, D Leonard, ... Cancer research 79 (16), 4242-4257, 2019 | 46 | 2019 |
Inactivation of PP2A by a recurrent mutation drives resistance to MEK inhibitors CM O’Connor, D Leonard, D Wiredja, RA Avelar, Z Wang, D Schlatzer, ... Oncogene 39 (3), 703-717, 2020 | 35 | 2020 |
Par-1b is required for morphogenesis and differentiation of myoepithelial cells during salivary gland development EM Gervais, SJ Sequeira, W Wang, S Abraham, JH Kim, D Leonard, ... Organogenesis 12 (4), 194-216, 2016 | 23 | 2016 |
Challenges and reinterpretation of antibody-based research on phosphorylation of Tyr307 on PP2Ac S Mazhar, D Leonard, A Sosa, D Schlatzer, D Thomas, G Narla Cell reports 30 (9), 3164-3170. e3, 2020 | 19 | 2020 |
Active and passive destabilization of G-quadruplex DNA by the telomere POT1-TPP1 complex M Xu, A Axhemi, M Malgowska, Y Chen, D Leonard, S Srinivasan, ... Journal of molecular biology 433 (7), 166846, 2021 | 8 | 2021 |
Pack a STRIPAK with hubs inside a hub W Huang, D Leonard, DJ Taylor Nature structural & molecular biology 28 (3), 232-233, 2021 | 6 | 2021 |
A Reply to'Cellular Toxicity of iHAP1 and DT-061 Does Not Occur Through PP2A-B56 Targeting' D Leonard, W Huang, DL Brautigan, A DiFeo, C O'Connor, E Ogris, ... Available at SSRN 3950751, 0 | 1 | |
Data for EMSL Project 51062 from September 2021 H Scott, D Leonard, D Taylor, W Huang Pacific Northwest National Lab.(PNNL), Richland, WA (United States …, 2021 | | 2021 |
Orchestrating PP2A Holoenzyme Assembly: From Normal to Abnormal and the Therapeutic Opportunity in Between DJ Leonard Case Western Reserve University, 2021 | | 2021 |
Data for EMSL Project 51062 from December 2020 H Scott, D Leonard, D Taylor, W Huang Pacific Northwest National Lab.(PNNL), Richland, WA (United States …, 2020 | | 2020 |
Biased activation of PP2A through selective heterotrimer binding and stabilization D Leonard, W Huang, S Izadmehr, CM O'Connor, DD Wiredja, Z Wang, ... Cancer Research 80 (16_Supplement), 2981-2981, 2020 | | 2020 |
Data for EMSL Project 51062 from March 2020 H Scott, D Leonard, D Taylor, W Huang Pacific Northwest National Lab.(PNNL), Richland, WA (United States …, 2020 | | 2020 |
Drug target mutations as a mechanism of acquired resistance to small molecules activators of protein phosphatase 2a R Tohme, J Sangodkar, J Kiselar, D Leonard, C O'Connor, S Gandhe, ... Cancer Research 77 (13_Supplement), 4173-4173, 2017 | | 2017 |
A novel M2-like macrophage mediated intracellular collagen degradation pathway identified by intravital imaging DH Madsen, D Leonard, A Masedunskas, A Moyer, HJ Jurgensen, ... MOLECULAR BIOLOGY OF THE CELL 24, 2013 | | 2013 |