A clinical-stage cysteine protease inhibitor blocks SARS-CoV-2 infection of human and monkey cells DM Mellott, CT Tseng, A Drelich, P Fajtová, BC Chenna, DH Kostomiris, ... ACS chemical biology 16 (4), 642-650, 2021 | 112 | 2021 |
Self-masked aldehyde inhibitors: a novel strategy for inhibiting cysteine proteases L Li, BC Chenna, KS Yang, TR Cole, ZT Goodall, M Giardini, ... Journal of medicinal chemistry 64 (15), 11267-11287, 2021 | 30 | 2021 |
Self-masked aldehyde inhibitors of human cathepsin L are potent anti-CoV-2 agents J Zhu, L Li, A Drelich, BC Chenna, DM Mellott, ZW Taylor, V Tat, ... Frontiers in Chemistry 10, 867928, 2022 | 12 | 2022 |
Dinitrosyl iron complexes (DNICs) as inhibitors of the SARS-CoV-2 main protease DC Pectol, CR DeLaney, J Zhu, DM Mellott, A Katzfuss, ZW Taylor, ... Chemical Communications 57 (67), 8352-8355, 2021 | 12 | 2021 |
SERRATE drives phase separation behaviours to regulate m6A modification and miRNA biogenesis S Zhong, X Li, C Li, H Bai, J Chen, L Gan, J Zhu, T Oh, X Yan, J Zhu, N Li, ... Nature Cell Biology, 1-15, 2024 | 3 | 2024 |
Catalytic Mechanism of SARS-CoV-2 3-Chymotrypsin-Like Protease as Determined by Steady-State and Pre-Steady-State Kinetics J Zhu, AM Kemp, BC Chenna, V Kumar, A Rademacher, S Yun, ... ACS Catalysis 14, 18292-18309, 2024 | 1 | 2024 |
Dual Inhibitors of SARS-CoV-2 3CL Protease and Human Cathepsin L Containing Glutamine Isosteres Are Anti-CoV-2 Agents V Kumar, J Zhu, BC Chenna, ZA Hoffpauir, A Rademacher, AM Rogers, ... Journal of the American Chemical Society, 2025 | | 2025 |
A broad cathepsin inhibitor blocks crystal-stimulated inflammasome-dependent and -independent inflammation, and gout arthritis JJL Laura Alejandra Ariza Orellano, Chunhui Zeng, Jiyun Zhu, Matthew Bogyo ... BioRxiv, 2024 | | 2024 |
Activity-Based Protein Profiling Identifies Klebsiella pneumoniae Serine Hydrolases with Potential Roles in Host-Pathogen Interactions MJ Uddin, G Randall, J Zhu, T Upadhyay, L van Eijk, P Stege, FM Masson, ... bioRxiv, 2024.05. 28.596221, 2024 | | 2024 |
A cysteine protease inhibitor blocks SARS-CoV-2 infection of human and monkey cells (preprint) D Mellott, CT Tseng, A Drelich, P Fajtova, BC Chenna, D Kostomiris, ... | | 2020 |