The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR RM Chin, X Fu, MY Pai, L Vergnes, H Hwang, G Deng, S Diep, ... Nature 510 (7505), 397-401, 2014 | 633 | 2014 |
Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips J Huang, H Zhu, SJ Haggarty, DR Spring, H Hwang, F Jin, M Snyder, ... Proceedings of the National Academy of Sciences 101 (47), 16594-16599, 2004 | 312 | 2004 |
Drug affinity responsive target stability (DARTS) for small-molecule target identification MY Pai, B Lomenick, H Hwang, R Schiestl, W McBride, JA Loo, J Huang Chemical Biology: Methods and Protocols, 287-298, 2015 | 285 | 2015 |
2-Hydroxyglutarate inhibits ATP synthase and mTOR signaling X Fu, RM Chin, L Vergnes, H Hwang, G Deng, Y Xing, MY Pai, S Li, L Ta, ... Cell metabolism 22 (3), 508-515, 2015 | 247 | 2015 |
Insights into TOR function and rapamycin response: chemical genomic profiling by using a high-density cell array method MW Xie, F Jin, H Hwang, S Hwang, V Anand, MC Duncan, J Huang Proceedings of the National Academy of Sciences 102 (20), 7215-7220, 2005 | 171 | 2005 |
Photodynamic therapy with 9-hydroxypheophorbide α on AMC-HN-3 human head and neck cancer cells: Induction of apoptosis via photoactivation of mitochondria and endoplasmic reticulum PS Chung, P He, JI Shin, HJ Hwang, SJ Lee, JC Ahn Cancer biology & therapy 8 (14), 1343-1351, 2009 | 40 | 2009 |
Modulation of EGFR and ROS induced cytochrome c release by combination of photodynamic therapy and carboplatin in human cultured head and neck cancer cells and tumor xenograft … H Hwang, R Biswas, PS Chung, JC Ahn Journal of Photochemistry and Photobiology B: Biology 128, 70-77, 2013 | 38 | 2013 |
Antioxidant and anti-apoptotic effect of melatonin on the vestibular hair cells of rat utricles JB Kim, JY Jung, JC Ahn, CK Rhee, HJ Hwang Clinical and Experimental Otorhinolaryngology 2 (1), 6-12, 2009 | 38 | 2009 |
Enhanced apoptotic effect of combined modality of 9-hydroxypheophorbide α-mediated photodynamic therapy and carboplatin on AMC-HN-3 human head and neck cancer cells P He, JC Ahn, JI Shin, HJ Hwang, JW Kang, SJ Lee, PS Chung Oncology reports 21 (2), 329-334, 2009 | 30 | 2009 |
Fine structural analysis of the central nervous system in the spider, Achaearanea tepidariorum (Theridiidae: Araneae) HJ HWANG, MJ MOON Entomological Research 33 (2), 119-126, 2003 | 15 | 2003 |
Enhancement of cytotoxic effect on human head and neck cancer cells by combination of photodynamic therapy and sulforaphane SJ Lee, HJ Hwang, JI Shin, JC Ahn, PS Chung Gen Physiol Biophys 34 (1), 13-21, 2015 | 14 | 2015 |
Combination treatment of Cetuximab and photodynamic therapy in SNU-1041 squamous cancer cell line SG Kim, JW Hong, SH Boo, MG Kim, KD Lee, JC Ahn, HJ Hwang, JI Shin, ... Oncology reports 22 (4), 701-708, 2009 | 13 | 2009 |
Ketobutyrate compounds and compositions for treating age-related symptoms and diseases J Huang, RM Chin, X Fu, H Hwang, K Reue, L Vergnes, M Jiang, ... US Patent 10,729,668, 2020 | 4 | 2020 |
Compositions and methods for treating aging and age-related diseases and symptoms J Huang, R Chin, S Diep, MY Pai, BE Lomenick, X Fu, K Reue, L Vergnes, ... US Patent App. 15/114,014, 2016 | 4 | 2016 |
Structural analysis of theridiid spider's testicular cyst using 3D reconstruction rendering H Kim, SR Jeong, HJ Hwang, MJ Moon Entomological Research 45 (5), 261-267, 2015 | 1 | 2015 |
Compositions and Methods for Treating Aging and Age-Related Diseases and Symptoms J Huang, RM Chin, S Diep, MY Pai, BE Lomenick, X Fu, KL Reue, ... US Patent App. 17/935,693, 2023 | | 2023 |
Alpha-Ketobutyrate, 2-Hydroxybutyrate, and Alpha-Ketoglutarate for Stimulating Hair Growth J Huang, M Chai, M Jiang, X Fu, H Hwang US Patent App. 18/154,498, 2023 | | 2023 |
The metabolite α-ketobutyrate increases health and life spans by activating AMPK C Chen, B Lomenick, M Chai, W Huang, J Chu, L Vergnes, ROB Johnson, ... bioRxiv, 2022.10. 10.511641, 2022 | | 2022 |
Alpha-Ketobutyrate, 2-Hydroxybutyrate, and Alpha-Ketoglutarate for Stimulating Hair Growth J Huang, M Chai, M Jiang, X Fu, H Hwang US Patent App. 16/332,763, 2019 | | 2019 |
Compositions and Methods for Treating Aging and Age-Related Diseases and Symptoms J Huang, RM Chin, S Diep, MY Pai, BE Lomenick, X Fu, K Reue, ... US Patent App. 16/297,590, 2019 | | 2019 |