Proteostasis of islet amyloid polypeptide: a molecular perspective of risk factors and protective strategies for type II diabetes D Milardi, E Gazit, SE Radford, Y Xu, RU Gallardo, A Caflisch, ... Chemical Reviews 121 (3), 1845-1893, 2021 | 153 | 2021 |
Amyloid growth and membrane damage: Current themes and emerging perspectives from theory and experiments on Aβ and hIAPP MFM Sciacca, C Tempra, F Scollo, D Milardi, C La Rosa Biochimica et Biophysica Acta (BBA)-Biomembranes 1860 (9), 1625-1638, 2018 | 133 | 2018 |
Lipid-chaperone hypothesis: A common molecular mechanism of membrane disruption by intrinsically disordered proteins MF Sciacca, F Lolicato, C Tempra, F Scollo, BR Sahoo, MD Watson, ... ACS chemical neuroscience 11 (24), 4336-4350, 2020 | 125 | 2020 |
Cations as switches of amyloid-mediated membrane disruption mechanisms: calcium and IAPP MFM Sciacca, D Milardi, GML Messina, G Marletta, JR Brender, ... Biophysical Journal 104 (1), 173-184, 2013 | 120 | 2013 |
α-helical structures drive early stages of self-assembly of amyloidogenic amyloid polypeptide aggregate formation in membranes M Pannuzzo, A Raudino, D Milardi, C La Rosa, M Karttunen Scientific reports 3 (1), 2781, 2013 | 107 | 2013 |
Insulin has multiple antiamyloidogenic effects on human neuronal cells G Pandini, V Pace, A Copani, S Squatrito, D Milardi, R Vigneri Endocrinology 154 (1), 375-387, 2013 | 105 | 2013 |
Multiple functions of insulin-degrading enzyme: a metabolic crosslight? GR Tundo, D Sbardella, C Ciaccio, G Grasso, M Gioia, A Coletta, ... Critical reviews in biochemistry and molecular biology 52 (5), 554-582, 2017 | 101 | 2017 |
Thermodynamics of the thermal unfolding of azurin C La Rosa, D Milardi, D Grasso, R Guzzi, L Sportelli The Journal of Physical Chemistry 99 (40), 14864-14870, 1995 | 100 | 1995 |
The role of cholesterol in driving IAPP-membrane interactions MFM Sciacca, F Lolicato, G Di Mauro, D Milardi, L D’Urso, C Satriano, ... Biophysical journal 111 (1), 140-151, 2016 | 93 | 2016 |
Carnosine Inhibits Aβ42 Aggregation by Perturbing the H‐Bond Network in and around the Central Hydrophobic Cluster F Attanasio, M Convertino, A Magno, A Caflisch, A Corazza, H Haridas, ... ChemBioChem 14 (5), 583-592, 2013 | 90 | 2013 |
Inhibition of Aβ amyloid growth and toxicity by silybins: The crucial role of stereochemistry MFM Sciacca, V Romanucci, A Zarrelli, I Monaco, F Lolicato, N Spinella, ... ACS chemical neuroscience 8 (8), 1767-1778, 2017 | 87 | 2017 |
The proteasome as a druggable target with multiple therapeutic potentialities: Cutting and non-cutting edges GR Tundo, D Sbardella, AM Santoro, A Coletta, F Oddone, G Grasso, ... Pharmacology & therapeutics 213, 107579, 2020 | 83 | 2020 |
Phospholipids critical micellar concentrations trigger different mechanisms of intrinsically disordered proteins interaction with model membranes F Scollo, C Tempra, F Lolicato, MFM Sciacca, A Raudino, D Milardi, ... The journal of physical chemistry letters 9 (17), 5125-5129, 2018 | 80 | 2018 |
Determination of the conformation of the human VDAC1 N‐terminal peptide, a protein moiety essential for the functional properties of the pore V De Pinto, F Tomasello, A Messina, F Guarino, R Benz, D La Mendola, ... Chembiochem 8 (7), 744-756, 2007 | 79 | 2007 |
Cationic Porphyrins Are Reversible Proteasome Inhibitors AM Santoro, MC Lo Giudice, A D’Urso, R Lauceri, R Purrello, D Milardi Journal of the American Chemical Society 134 (25), 10451-10457, 2012 | 70 | 2012 |
Extended theoretical analysis of irreversible protein thermal unfolding D Milardi, C La Rosa, D Grasso Biophysical chemistry 52 (3), 183-189, 1994 | 69 | 1994 |
The role of copper(ii) in the aggregation of human amylin A Sinopoli, A Magrì, D Milardi, M Pappalardo, P Pucci, A Flagiello, ... Metallomics 6 (10), 1841-1852, 2014 | 65 | 2014 |
A spectroscopic and calorimetric investigation on the thermal stability of the Cys3Ala/Cys26Ala azurin mutant R Guzzi, L Sportelli, C La Rosa, D Milardi, D Grasso, MP Verbeet, ... Biophysical journal 77 (2), 1052-1063, 1999 | 62 | 1999 |
Extracellular truncated tau causes early presynaptic dysfunction associated with Alzheimer’s disease and other tauopathies F Florenzano, C Veronica, G Ciasca, MT Ciotti, A Pittaluga, G Olivero, ... Oncotarget 8 (39), 64745, 2017 | 61 | 2017 |
The role of aromatic side-chains in amyloid growth and membrane interaction of the islet amyloid polypeptide fragment LANFLVH D Milardi, MFM Sciacca, M Pappalardo, DM Grasso, C La Rosa European Biophysics Journal 40 (1), 1-12, 2011 | 57 | 2011 |