The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs G Reid, P Wielinga, N Zelcer, I van der Heijden, A Kuil, M de Haas, ... Proceedings of the National Academy of Sciences 100 (16), 9244-9249, 2003 | 664 | 2003 |
Mrp4 confers resistance to topotecan and protects the brain from chemotherapy M Leggas, M Adachi, GL Scheffer, D Sun, P Wielinga, G Du, KE Mercer, ... Molecular and cellular biology 24 (17), 7612-7621, 2004 | 525 | 2004 |
Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5 G Reid, P Wielinga, N Zelcer, M De Haas, L Van Deemter, J Wijnholds, ... Molecular pharmacology 63 (5), 1094-1103, 2003 | 464 | 2003 |
The effect of Bcrp1 (Abcg2) on the in vivo pharmacokinetics and brain penetration of imatinib mesylate (Gleevec): implications for the use of breast cancer resistance protein … P Breedveld, D Pluim, G Cipriani, P Wielinga, O van Tellingen, ... Cancer research 65 (7), 2577-2582, 2005 | 450 | 2005 |
Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4) N Zelcer, G Reid, P Wielinga, A Kuil, I van der Heijden, JD Schuetz, ... Biochemical Journal 371 (2), 361-367, 2003 | 376 | 2003 |
Characterization of the MRP4-and MRP5-mediated transport of cyclic nucleotides from intact cells PR Wielinga, I van der Heijden, G Reid, JH Beijnen, J Wijnholds, P Borst Journal of Biological Chemistry 278 (20), 17664-17671, 2003 | 341 | 2003 |
Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export R Evers, M De Haas, R Sparidans, J Beijnen, PR Wielinga, J Lankelma, ... British journal of cancer 83 (3), 375-383, 2000 | 280 | 2000 |
Mice lacking multidrug resistance protein 3 show altered morphine pharmacokinetics and morphine-6-glucuronide antinociception N Zelcer, K van de Wetering, M Hillebrand, E Sarton, A Kuil, PR Wielinga, ... Proceedings of the National Academy of Sciences 102 (20), 7274-7279, 2005 | 248 | 2005 |
Molecular epidemiology of Cryptosporidium in humans and cattle in The Netherlands PR Wielinga, A de Vries, TH van der Goot, T Mank, MH Mars, ... International journal for parasitology 38 (7), 809-817, 2008 | 244 | 2008 |
Evidence for two interacting ligand binding sites in human multidrug resistance protein 2 (ATP binding cassette C2) N Zelcer, MT Huisman, G Reid, P Wielinga, P Breedveld, A Kuil, ... Journal of Biological Chemistry 278 (26), 23538-23544, 2003 | 239 | 2003 |
Thiopurine metabolism and identification of the thiopurine metabolites transported by MRP4 and MRP5 overexpressed in human embryonic kidney cells PR Wielinga, G Reid, EE Challa, I Van der Heijden, L Van Deemter, ... Molecular pharmacology 62 (6), 1321-1331, 2002 | 223 | 2002 |
The multidrug resistance protein 1 (Mrp1), but not Mrp5, mediates export of glutathione and glutathione disulfide from brain astrocytes T Minich, J Riemer, JB Schulz, P Wielinga, J Wijnholds, R Dringen Journal of neurochemistry 97 (2), 373-384, 2006 | 212 | 2006 |
Mice lacking Mrp3 (Abcc3) have normal bile salt transport, but altered hepatic transport of endogenous glucuronides N Zelcer, K van de Wetering, R de Waart, GL Scheffer, HU Marschall, ... Journal of hepatology 44 (4), 768-775, 2006 | 210 | 2006 |
Ixodes ricinus ticks are reservoir hosts for Rickettsia helvetica and potentially carry flea-borne Rickettsia species H Sprong, PR Wielinga, M Fonville, C Reusken, AH Brandenburg, ... Parasites & vectors 2, 1-7, 2009 | 208 | 2009 |
Longitudinal Analysis of Tick Densities and Borrelia, Anaplasma, and Ehrlichia Infections of Ixodes ricinus Ticks in Different Habitat Areas in The Netherlands PR Wielinga, C Gaasenbeek, M Fonville, A de Boer, A de Vries, ... Applied and environmental microbiology 72 (12), 7594-7601, 2006 | 193 | 2006 |
Expression of multidrug transporter MRP4/ABCC4 is a marker of poor prognosis in neuroblastoma and confers resistance to irinotecan in vitro MD Norris, J Smith, K Tanabe, P Tobin, C Flemming, GL Scheffer, ... Molecular cancer therapeutics 4 (4), 547-553, 2005 | 185 | 2005 |
The human multidrug resistance protein MRP5 transports folates and can mediate cellular resistance against antifolates P Wielinga, JH Hooijberg, S Gunnarsdottir, I Kathmann, G Reid, N Zelcer, ... Cancer research 65 (10), 4425-4430, 2005 | 171 | 2005 |
Genotyping of Giardia in Dutch patients and animals: a phylogenetic analysis of human and animal isolates JWB Van der Giessen, A De Vries, M Roos, P Wielinga, LM Kortbeek, ... International Journal for Parasitology 36 (7), 849-858, 2006 | 135 | 2006 |
Lyme borreliosis in the Netherlands: strong increase in GP consultations and hospital admissions in past 10 years A Hofhuis, JWB Van der Giessen, FHM Borgsteede, PR Wielinga, ... Weekly releases (1997–2007) 11 (25), 2978, 2006 | 99 | 2006 |
Detection of Coxiella burnetii in complex matrices by using multiplex quantitative PCR during a major Q fever outbreak in The Netherlands A De Bruin, A De Groot, L De Heer, J Bok, PR Wielinga, M Hamans, ... Applied and Environmental Microbiology 77 (18), 6516-6523, 2011 | 95 | 2011 |