| Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3β/β-catenin signaling Y Mao, X Ge, CL Frank, JM Madison, AN Koehler, MK Doud, C Tassa, ... Cell 136 (6), 1017-1031, 2009 | 922 | 2009 |
| Printing small molecules as microarrays and detecting protein− ligand interactions en masse G MacBeath, AN Koehler, SL Schreiber Journal of the American Chemical Society 121 (34), 7967-7968, 1999 | 619 | 1999 |
| Identifying the proteins to which small-molecule probes and drugs bind in cells SE Ong, M Schenone, AA Margolin, X Li, K Do, MK Doud, DR Mani, ... Proceedings of the National Academy of Sciences 106 (12), 4617-4622, 2009 | 383 | 2009 |
| A small molecule that binds Hedgehog and blocks its signaling in human cells BZ Stanton, LF Peng, N Maloof, K Nakai, X Wang, JL Duffner, KM Taveras, ... Nature chemical biology 5 (3), 154-156, 2009 | 374 | 2009 |
| Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles PA Clemons, NE Bodycombe, HA Carrinski, JA Wilson, AF Shamji, ... Proceedings of the National Academy of Sciences 107 (44), 18787-18792, 2010 | 351 | 2010 |
| Advances in targeting ‘undruggable’transcription factors with small molecules MJ Henley, AN Koehler Nature Reviews Drug Discovery 20 (9), 669-688, 2021 | 243 | 2021 |
| A complex task? Direct modulation of transcription factors with small molecules AN Koehler Current opinion in chemical biology 14 (3), 331-340, 2010 | 241 | 2010 |
| Binding affinity and kinetic analysis of targeted small molecule-modified nanoparticles C Tassa, JL Duffner, TA Lewis, R Weissleder, SL Schreiber, AN Koehler, ... Bioconjugate chemistry 21 (1), 14-19, 2010 | 228 | 2010 |
| Discovery of an inhibitor of a transcription factor using small molecule microarrays and diversity-oriented synthesis AN Koehler, AF Shamji, SL Schreiber Journal of the American Chemical Society 125 (28), 8420-8421, 2003 | 225 | 2003 |
| A robust small-molecule microarray platform for screening cell lysates JE Bradner, OM McPherson, R Mazitschek, D Barnes-Seeman, JP Shen, ... Chemistry & biology 13 (5), 493-504, 2006 | 162 | 2006 |
| Expanding the functional group compatibility of small‐molecule microarrays: discovery of novel calmodulin ligands D Barnes‐Seeman, SB Park, AN Koehler, SL Schreiber Angewandte Chemie 115 (21), 2478-2481, 2003 | 139 | 2003 |
| A one-bead, one-stock solution approach to chemical genetics: part 2 PA Clemons, AN Koehler, BK Wagner, TG Sprigings, DR Spring, RW King, ... Chemistry & Biology 8 (12), 1183-1195, 2001 | 135 | 2001 |
| Massively parallel pooled screening reveals genomic determinants of nanoparticle delivery N Boehnke, JP Straehla, HC Safford, M Kocak, MG Rees, M Ronan, ... Science 377 (6604), eabm5551, 2022 | 128 | 2022 |
| Stabilization of the Max homodimer with a small molecule attenuates Myc-driven transcription NB Struntz, A Chen, A Deutzmann, RM Wilson, E Stefan, HL Evans, ... Cell chemical biology 26 (5), 711-723. e14, 2019 | 122 | 2019 |
| A pipeline for ligand discovery using small-molecule microarrays JL Duffner, PA Clemons, AN Koehler Current opinion in chemical biology 11 (1), 74-82, 2007 | 118 | 2007 |
| Quantifying structure and performance diversity for sets of small molecules comprising small-molecule screening collections PA Clemons, JA Wilson, V Dančík, S Muller, HA Carrinski, BK Wagner, ... Proceedings of the National Academy of Sciences 108 (17), 6817-6822, 2011 | 110 | 2011 |
| Fluorous‐based small‐molecule microarrays for the discovery of histone deacetylase inhibitors AJ Vegas, JE Bradner, W Tang, OM McPherson, EF Greenberg, ... Angewandte Chemie 119 (42), 8106-8110, 2007 | 110 | 2007 |
| Small molecule microarrays enable the discovery of compounds that bind the Alzheimer’s Aβ peptide and reduce its cytotoxicity J Chen, AH Armstrong, AN Koehler, MH Hecht Journal of the American Chemical Society 132 (47), 17015-17022, 2010 | 109 | 2010 |
| Small-molecule microarrays as tools in ligand discovery AJ Vegas, JH Fuller, AN Koehler Chemical Society Reviews 37 (7), 1385-1394, 2008 | 106 | 2008 |
| Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics L De Waal, TA Lewis, MG Rees, A Tsherniak, X Wu, PS Choi, L Gechijian, ... Nature chemical biology 12 (2), 102-108, 2016 | 105 | 2016 |
