| Intracellular delivery of bioactive AZT nucleotides by aryl phosphate derivatives of AZT C McGuigan, RN Pathirana, J Balzarini, E De Clercq Journal of Medicinal Chemistry 36 (8), 1048-1052, 1993 | 340 | 1993 |
| Boronic acids in medicinal chemistry: anticancer, antibacterial and antiviral applications PC Trippier, C McGuigan MedChemComm 1 (3), 183-198, 2010 | 336 | 2010 |
| Aryl phosphoramidate derivatives of d4T have improved anti-HIV efficacy in tissue culture and may act by the generation of a novel intracellular metabolite C McGuigan, D Cahard, HM Sheeka, E De Clercq, J Balzarini Journal of medicinal chemistry 39 (8), 1748-1753, 1996 | 323 | 1996 |
| Aryloxy phosphoramidate triesters: a technology for delivering monophosphorylated nucleosides and sugars into cells Y Mehellou, J Balzarini, C McGuigan ChemMedChem: Chemistry Enabling Drug Discovery 4 (11), 1779-1791, 2009 | 292 | 2009 |
| Aryloxy phosphoramidate triesters as pro-tides. D Cahard, C McGuigan, J Balzarini Mini Reviews in Medicinal Chemistry 4 (4), 371-381, 2004 | 261 | 2004 |
| Potent and selective inhibition of varicella-zoster virus (VZV) by nucleoside analogues with an unusual bicyclic base C McGuigan, CJ Yarnold, G Jones, S Velázquez, H Barucki, A Brancale, ... Journal of medicinal chemistry 42 (22), 4479-4484, 1999 | 260 | 1999 |
| Highly potent and selective inhibition of varicella-zoster virus by bicyclic furopyrimidine nucleosides bearing an aryl side chain C McGuigan, H Barucki, S Blewett, A Carangio, JT Erichsen, G Andrei, ... Journal of medicinal chemistry 43 (26), 4993-4997, 2000 | 241 | 2000 |
| Aryl phosphate derivatives of AZT retain activity against HIV1 in cell lines which are resistant to the action of AZT C McGuigan, RN Pathirana, N Mahmood, KG Devine, AJ Hay Antiviral research 17 (4), 311-321, 1992 | 230 | 1992 |
| Application of ProTide technology to gemcitabine: a successful approach to overcome the key cancer resistance mechanisms leads to a new agent (NUC-1031) in clinical development M Slusarczyk, MH Lopez, J Balzarini, M Mason, WG Jiang, S Blagden, ... Journal of medicinal chemistry 57 (4), 1531-1542, 2014 | 194 | 2014 |
| Mechanism of anti-HIV action of masked alaninyl d4T-MP derivatives. J Balzarini, A Karlsson, S Aquaro, CF Perno, D Cahard, L Naesens, ... Proceedings of the National Academy of Sciences 93 (14), 7295-7299, 1996 | 192 | 1996 |
| Characterization of the activation pathway of phosphoramidate triester prodrugs of stavudine and zidovudine D Saboulard, L Naesens, D Cahard, A Salgado, R Pathirana, ... Molecular Pharmacology 56 (4), 693-704, 1999 | 189 | 1999 |
| The presence of substituents on the aryl moiety of the aryl phosphoramidate derivative of d4T enhances anti-HIV efficacy in cell culture: a structure− activity relationship AQ Siddiqui, C Ballatore, C McGuigan, E De Clercq, J Balzarini Journal of Medicinal Chemistry 42 (3), 393-399, 1999 | 165 | 1999 |
| Phosphoramidate compounds and methods of use C McGuigan US Patent 7,951,787, 2011 | 164 | 2011 |
| Design, synthesis and evaluation of a novel double pro-drug: INX-08189. A new clinical candidate for hepatitis C virus C McGuigan, K Madela, M Aljarah, A Gilles, A Brancale, N Zonta, ... Bioorganic & medicinal chemistry letters 20 (16), 4850-4854, 2010 | 149 | 2010 |
| Bicyclic pyrimidine nucleoside analogues (BCNAs) as highly selective and potent inhibitors of varicella-zoster virus replication J Balzarini, C McGuigan Journal of Antimicrobial Chemotherapy 50 (1), 5-9, 2002 | 148 | 2002 |
| Medicinal chemistry of nucleoside phosphonate prodrugs for antiviral therapy F Pertusat, M Serpi, C McGuigan Antiviral Chemistry and Chemotherapy 22 (5), 181-203, 2012 | 145 | 2012 |
| Phosphoramidate ProTides of the anticancer agent FUDR successfully deliver the preformed bioactive monophosphate in cells and confer advantage over the parent nucleoside C McGuigan, P Murziani, M Slusarczyk, B Gonczy, J Vande Voorde, ... Journal of medicinal chemistry 54 (20), 7247-7258, 2011 | 140 | 2011 |
| Antiviral phosphoramidates K Klumpp, JA Martin, C McGuigan, DB Smith US Patent 7,608,599, 2009 | 140 | 2009 |
| Acyclovir is activated into a HIV-1 reverse transcriptase inhibitor in herpesvirus-infected human tissues A Lisco, C Vanpouille, EP Tchesnokov, JC Grivel, A Biancotto, ... Cell host & microbe 4 (3), 260-270, 2008 | 140 | 2008 |
| Application of phosphoramidate pronucleotide technology to abacavir leads to a significant enhancement of antiviral potency C McGuigan, SA Harris, SM Daluge, KS Gudmundsson, EW McLean, ... Journal of medicinal chemistry 48 (10), 3504-3515, 2005 | 137 | 2005 |
